-
1
-
-
41949097030
-
The biology of interleukin-2
-
DOI 10.1146/annurev.immunol.26.021607.090357
-
Malek TR. The biology of interleukin-2. Annu. Rev. Immunol. 26, 453-479 (2008). (Pubitemid 351600382)
-
(2008)
Annual Review of Immunology
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
2
-
-
51849108540
-
The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation
-
Bluestone JA, Liu W, Yabu JM et al. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation. Am. J. Transplant. 8(10), 2086-2096 (2008).
-
(2008)
Am. J. Transplant.
, vol.8
, Issue.10
, pp. 2086-2096
-
-
Bluestone, J.A.1
Liu, W.2
Yabu, J.M.3
-
3
-
-
77950638599
-
Impact of basiliximab on regulatory T-cells early after kidney transplantation: Down-regulation of CD25 by receptor modulation
-
Vondran FW, Timrott K, Tross J et al. Impact of basiliximab on regulatory T-cells early after kidney transplantation: down-regulation of CD25 by receptor modulation. Transplant. Int. 23(5), 514-523 (2010).
-
(2010)
Transplant. Int.
, vol.23
, Issue.5
, pp. 514-523
-
-
Vondran, F.W.1
Timrott, K.2
Tross, J.3
-
5
-
-
73949084381
-
ATG-induced expression of FOXP3 in human CD4(+)T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells
-
Broady R, Yu J, Levings MK. ATG-induced expression of FOXP3 in human CD4(+)T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells. Blood 114(24), 5003-5006 (2009).
-
(2009)
Blood
, vol.114
, Issue.24
, pp. 5003-5006
-
-
Broady, R.1
Yu, J.2
Levings, M.K.3
-
6
-
-
33751183486
-
+CD25 bright + regulatory T cells can mediate donor nonreactivity in long-term immunosuppressed kidney allograft patients
-
+CD25 bright + regulatory T cells can mediate donor nonreactivity in long-term immunosuppressed kidney allograft patients. Am. J. Transplant. 6(12), 2955-2964 (2006).
-
(2006)
Am. J. Transplant.
, vol.6
, Issue.12
, pp. 2955-2964
-
-
Velthuis, J.H.1
Mol, W.M.2
Weimar, W.3
Baan, C.C.4
-
8
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
DOI 10.1073/pnas.0800928105
-
Sauer S, Bruno L, Hertweck A et al. T cell receptor signaling controls Foxp3 expression via PI3K, AKT, and mTOR. Proc. Natl Acad. Sci. USA 105(22), 7797-7802 (2008). (Pubitemid 351872718)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.22
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
Cobb, B.S.8
Cantrell, D.9
O'Connor, E.10
Shokat, K.M.11
Fisher, A.G.12
Merkenschlager, M.13
-
9
-
-
84855999161
-
Belatacept: From rational design to clinical application
-
Wekerle T, Grinyo JM. Belatacept: from rational design to clinical application. Transplant. Int. 25, 139-150 (2012).
-
(2012)
Transplant. Int.
, vol.25
, pp. 139-150
-
-
Wekerle, T.1
Grinyo, J.M.2
-
10
-
-
20044386299
-
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties
-
DOI 10.1111/j.1600-6143.2005.00749.x
-
Larsen CP, Pearson TC, Adams AB et al. Rational development of LEA29Y (belatacept), a high-affnity variant of CTLA4-Ig with potent immunosuppressive properties. Am. J. Transplant. 5(3), 443-453 (2005). (Pubitemid 40313335)
-
(2005)
American Journal of Transplantation
, vol.5
, Issue.3
, pp. 443-453
-
-
Larsen, C.P.1
Pearson, T.C.2
Adams, A.B.3
Tso, P.4
Shirasugi, N.5
Strobert, E.6
Anderson, D.7
Cowan, S.8
Price, K.9
Naemura, J.10
Emswiler, J.11
Greene, J.12
Turk, L.A.13
Bajorath, J.14
Townsend, R.15
Hagerty, D.16
Linsley, P.S.17
Peach, R.J.18
-
11
-
-
23944502334
-
Costimulation blockade with belatacept in renal transplantation
-
DOI 10.1056/NEJMoa050085
-
Vincenti F, Larsen C, Durrbach A et al. Costimulation blockade with belatacept in renal transplantation. N. Engl. J. Med. 353(8), 770-781 (2005). (Pubitemid 41215486)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.8
, pp. 770-781
-
-
Vincenti, F.1
Larsen, C.2
Durrbach, A.3
Wekerle, T.4
Nashan, B.5
Blancho, G.6
Lang, P.7
Grinyo, J.8
Halloran, P.F.9
Solez, K.10
Hagerty, D.11
Levy, E.12
Zhou, W.13
Natarajan, K.14
Charpentier, B.15
-
12
-
-
76949101581
-
A Phase 3 study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study)
-
Vincenti F, Charpentier B, Vanrenterghem Y et al. A Phase 3 study of belatacept-based immunosuppression regimens versus cyclosporine in renal transplant recipients (BENEFIT study). Am. J. Transplant. 10(3), 535-546 (2010).
-
(2010)
Am. J. Transplant.
, vol.10
, Issue.3
, pp. 535-546
-
-
Vincenti, F.1
Charpentier, B.2
Vanrenterghem, Y.3
-
13
-
-
76949090842
-
A Phase 3 study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study)
-
Durrbach A, Pestana JM, Pearson T et al. A Phase 3 study of belatacept versus cyclosporine in kidney transplants from extended criteria donors (BENEFIT-EXT study). Am. J. Transplant. 10(3), 547-557 (2010).
-
(2010)
Am. J. Transplant.
, vol.10
, Issue.3
, pp. 547-557
-
-
Durrbach, A.1
Pestana, J.M.2
Pearson, T.3
-
14
-
-
34247580749
-
Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with Belatacept mediated CD28-CD80/86 blockade
-
DOI 10.1016/j.trim.2007.01.005, PII S0966327407000068
-
Chavez H, Beaudreuil S, Abbed K et al. Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with belatacept mediated CD28-CD80/86 blockade. Transplant. Immunol. 17(4), 243-248 (2007). (Pubitemid 46687025)
-
(2007)
Transplant Immunology
, vol.17
, Issue.4
, pp. 243-248
-
-
Chavez, H.1
Beaudreuil, S.2
Abbed, K.3
Taoufic, Y.4
Kriaa, F.5
Charpentier, B.6
Durrbach, A.7
-
15
-
-
79953800720
-
Costimulatory blockade with mTOR inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation
-
Bestard O, Cassis L, Cruzado JM et al. Costimulatory blockade with mTOR inhibition abrogates effector T-cell responses allowing regulatory T-cell survival in renal transplantation. Transplant. Int. 24(5), 451-46 0 (2011).
-
(2011)
Transplant. Int.
, vol.24
, Issue.5
, pp. 451-460
-
-
Bestard, O.1
Cassis, L.2
Cruzado, J.M.3
-
16
-
-
79952165892
-
T-cell phenotype in protocol renal biopsy from transplant recipients treated with belatacept-mediated co-stimulatory blockade
-
Grimbert P, Audard V, Diet C et al. T-c e l l phenotype in protocol renal biopsy from transplant recipients treated with belatacept-mediated co-stimulatory blockade. Nephrol. Dial. Transplant. 26(3), 1087-1093 (2011).
-
(2011)
Nephrol. Dial. Transplant.
, vol.26
, Issue.3
, pp. 1087-1093
-
-
Grimbert, P.1
Audard, V.2
Diet, C.3
-
17
-
-
78649475483
-
+ peripheral cells, and Tregs in graft biopsies from kidney transplant recipients under belatacept treatment
-
+ peripheral cells, and Tregs in graft biopsies from kidney transplant recipients under belatacept treatment. Transplant. Proc. 42(9), 3489-3496 (2010).
-
(2010)
Transplant. Proc.
, vol.42
, Issue.9
, pp. 3489-3496
-
-
Furuzawa-Carballeda, J.1
Lima, G.2
Uribe-Uribe, N.3
-
18
-
-
28244444532
-
Messenger RNA for FOXP3 in the urine of renal-allograft recipients
-
DOI 10.1056/NEJMoa051907
-
Muthukumar T, Dadhania D, Ding R et al. Messenger RNA for FOXP3 in the urine of renal-allograft recipients. N. Engl. J. Med. 353(22), 2342-2351 (2005). (Pubitemid 41713746)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.22
, pp. 2342-2351
-
-
Muthukumar, T.1
Dadhania, D.2
Ding, R.3
Snopkowski, C.4
Naqvi, R.5
Lee, J.B.6
Hartono, C.7
Li, B.8
Sharma, V.K.9
Seshan, S.V.10
Kapur, S.11
Hancock, W.W.12
Schwartz, J.E.13
Suthanthiran, M.14
-
19
-
-
80054851680
-
Costimulatory pathways in transplantation
-
Pilat N, Sayegh MH, Wekerle T. Costimulatory pathways in transplantation. Semin. Immunol. 23(4), 293-303 (2011).
-
(2011)
Semin. Immunol.
, vol.23
, Issue.4
, pp. 293-303
-
-
Pilat, N.1
Sayegh, M.H.2
Wekerle, T.3
-
20
-
-
0030966217
-
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
-
Perez Vl, van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6(4), 411-417 (1997). (Pubitemid 27208196)
-
(1997)
Immunity
, vol.6
, Issue.4
, pp. 411-417
-
-
Perez, V.L.1
Van Parijs, L.2
Biuckians, A.3
Zheng, X.X.4
Strom, T.B.5
Abbas, A.K.6
-
21
-
-
0004880266
-
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
-
Zheng XX, Markees TG, Hancock WW et al. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J. Immunol. 162(8), 4983-4990 (1999). (Pubitemid 29314906)
-
(1999)
Journal of Immunology
, vol.162
, Issue.8
, pp. 4983-4990
-
-
Zheng, X.X.1
Markees, T.G.2
Hancock, W.W.3
Li, Y.4
Greiner, D.L.5
Li, X.C.6
Mordes, J.P.7
Sayegh, M.H.8
Rossini, A.A.9
Strom, T.B.10
-
23
-
-
82255192901
-
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
-
Walker LS, Sansom DM. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat. Rev. Immunol. 11(12), 852-863 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, Issue.12
, pp. 852-863
-
-
Walker, L.S.1
Sansom, D.M.2
-
24
-
-
79955529454
-
Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
-
Qureshi OS, Zheng Y, Nakamura K et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science 332(6029), 600-603 (2011).
-
(2011)
Science
, vol.332
, Issue.6029
, pp. 600-603
-
-
Qureshi, O.S.1
Zheng, Y.2
Nakamura, K.3
-
25
-
-
82755198003
-
Regulatory T cell lineage commitment in the thymus
-
Klein L, Jovanovic K. Regulatory T cell lineage commitment in the thymus. Semin. Immunol. 23(6), 401-409 (2011).
-
(2011)
Semin. Immunol.
, vol.23
, Issue.6
, pp. 401-409
-
-
Klein, L.1
Jovanovic, K.2
-
26
-
-
82155170171
-
B7/CD28 in central tolerance: Costimulation promotes maturation of regulatory T cell precursers and prevents their clonal deletion
-
Hinterberger M, Wirnsberger G, Klein L. B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursers and prevents their clonal deletion. Front. Immun. 2, 30 (2011).
-
(2011)
Front. Immun.
, vol.2
, pp. 30
-
-
Hinterberger, M.1
Wirnsberger, G.2
Klein, L.3
-
27
-
-
0141920662
-
+ regulatory T cells
-
+ regulatory T cells. J. Immunol. 171(7), 3348-3352 (2003). (Pubitemid 37254533)
-
(2003)
Journal of Immunology
, vol.171
, Issue.7
, pp. 3348-3352
-
-
Tang, Q.1
Henriksen, K.J.2
Boden, E.K.3
Tooley, A.J.4
Ye, J.5
Subudhi, S.K.6
Zheng, X.X.7
Strom, T.B.8
Bluestone, J.A.9
-
28
-
-
0033682056
-
+ immunoregulatory T cells that control autoimmune diabetes
-
+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12(4), 431-440 (2000).
-
(2000)
Immunity
, vol.12
, Issue.4
, pp. 431-440
-
-
Salomon, B.1
Lenschow, D.J.2
Rhee, L.3
-
29
-
-
20544457031
-
The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade
-
DOI 10.1111/j.1600-6143.2005.00862.x
-
Bigenzahn S, Blaha P, Koporc Z et al. The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. Am. J. Transplant. 5(6), 1237-1247 (2005). (Pubitemid 40839411)
-
(2005)
American Journal of Transplantation
, vol.5
, Issue.6
, pp. 1237-1247
-
-
Bigenzahn, S.1
Blaha, P.2
Koporc, Z.3
Pree, I.4
Selzer, E.5
Bergmeister, H.6
Wrba, F.7
Heusser, C.8
Wagner, K.9
Muehlbacher, F.10
Wekerle, T.11
-
30
-
-
48249147441
-
+ regulatory T cells
-
+ regulatory T cells. Proc. Natl Acad. Sci. USA 105(27), 9331-9336 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, Issue.27
, pp. 9331-9336
-
-
Wang, L.1
Pino-Lagos, K.2
De Vries, V.C.3
Guleria, I.4
Sayegh, M.H.5
Noelle, R.J.6
-
31
-
-
73949088551
-
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
-
Francisco LM, Salinas VH, Brown KE et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J. Exp. Med. 206(13), 3015-3029 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, Issue.13
, pp. 3015-3029
-
-
Francisco, L.M.1
Salinas, V.H.2
Brown, K.E.3
-
32
-
-
82655184651
-
The PDL1-PD1 axis converts human TH1 cells into regulatory T cells
-
Amarnath S, Mangus CW, Wang JC et al. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci. Transl. Med. 3 (111), 111r a12 0 (2011).
-
(2011)
Sci. Transl. Med.
, vol.3
, Issue.111
, pp. 111-120
-
-
Amarnath, S.1
Mangus, C.W.2
Wang, J.C.3
-
33
-
-
34447646310
-
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
-
DOI 10.1016/j.immuni.2007.05.016, PII S1074761307003287
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27(1), 111-122 (2007). (Pubitemid 47089023)
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
34
-
-
80051621113
-
The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo
-
Yang J, Riella LV, Chock S et al. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J. Immunol. 187(3), 1113-1119 (2011).
-
(2011)
J. Immunol.
, vol.187
, Issue.3
, pp. 1113-1119
-
-
Yang, J.1
Riella, L.V.2
Chock, S.3
-
35
-
-
0035253345
-
CTLA4Ig-induced linked regulation of allogeneic T cell responses
-
Lee RS, Rusche JR, Maloney ME, Sachs DH, Sayegh MH, Madsen JC. CTLA4Ig-induced linked regulation of allogeneic T cell responses. J. Immunol. 166(3), 1572-1582 (2001). (Pubitemid 32114637)
-
(2001)
Journal of Immunology
, vol.166
, Issue.3
, pp. 1572-1582
-
-
Lee, R.S.1
Rusche, J.R.2
Maloney, M.E.3
Sachs, D.H.4
Sayegh, M.H.5
Madsen, J.C.6
-
36
-
-
0036773925
-
Mechanisms of transplant tolerance induction using costimulatory blockade
-
Wekerle T, Kurtz J, Bigenzahn S, Takeuchi Y, Sykes M. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr. Opin Immunol. 14(5), 592-600 (2002).
-
(2002)
Curr. Opin Immunol.
, vol.14
, Issue.5
, pp. 592-600
-
-
Wekerle, T.1
Kurtz, J.2
Bigenzahn, S.3
Takeuchi, Y.4
Sykes, M.5
-
37
-
-
84855370788
-
IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated ag-4 Ig-mediated long-term solid organ allograft survival
-
Sucher R, Fischler K, Oberhuber R et al. IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated ag-4 Ig-mediated long-term solid organ allograft survival. J. Immunol. 188(1), 37-46 (2011).
-
(2011)
J. Immunol.
, vol.188
, Issue.1
, pp. 37-46
-
-
Sucher, R.1
Fischler, K.2
Oberhuber, R.3
-
38
-
-
77949852097
-
Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning
-
Pilat N, Baranyi U, Klaus C et al. Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning. Am. J. Transplant. 10 (4), 751-762 (2010).
-
(2010)
Am. J. Transplant.
, vol.10
, Issue.4
, pp. 751-762
-
-
Pilat, N.1
Baranyi, U.2
Klaus, C.3
-
39
-
-
79961026257
-
Therapeutic effcacy of polyclonal Tregs does not require rapamycin in a low-dose irradiation bone marrow transplantation model
-
Pilat N, Klaus C, Gattringer M et al. Therapeutic effcacy of polyclonal Tregs does not require rapamycin in a low-dose irradiation bone marrow transplantation model. Transplantation 92(3), 280-288 (2011).
-
(2011)
Transplantation
, vol.92
, Issue.3
, pp. 280-288
-
-
Pilat, N.1
Klaus, C.2
Gattringer, M.3
|