Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells

Journal of Asian Natural Products Research

Volumn 14, Issue 7, 2012, Pages 657-664

  Wang, Ya Jie ^a   Chen, Xiao Guang ^a   Xiao, Zhi Yan ^a   Liu, Geng Tao ^a   Sun, Hua ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

ATM; cell cycle; Chk2; GL331; p53

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; CHECKPOINT KINASE 2; CYCLIN A; GL 331; GYRASE INHIBITOR; HISTONE H2AX; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL STRAIN HEPG2; DNA DAMAGE; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

CELL CYCLE; CELL CYCLE CHECKPOINTS; DNA DAMAGE; ETOPOSIDE; HEP G2 CELLS; HISTONES; HUMANS; MOLECULAR STRUCTURE; TOPOISOMERASE II INHIBITORS;

ATAXIA TELANGIECTASIA;

EID: 84864709548     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2012.684683     Document Type: Article

References (24)

1. Lee, C.C., and, Huang, T.S. 2001. Pharm. Res., 18: 846
2. Huang, T.S., Lee, C.C., Chao, Y., Shu, C.H., Chen, L.T., Chen, L.L., Chen, M.H., Yuan, C.C., and, Whang-Peng, J. 1999. Pharm. Res., 16: 997
3. Huang, T.S., Shu, C.H., Shih, Y.L., Huang, H.C., Su, Y.C., Chao, Y., Yang, W.K., and, Whang-Peng, J. 1996. Cancer Lett., 110: 77
4. Huang, T.S., Shu, C.H., Yang, W.K., and, Whang-Peng, J. 1997. Cancer Res., 57: 2974
5. Kuo, M.L., Shen, S.C., Yang, C.H., Chuang, S.E., Cheng, A.L., and, Huang, T.S. 1998. Oncogene, 17: 2225
6. Chang, H., Shyu, K.G., Lee, C.C., Tsai, S.C., and, Wang, B.W. 2003. Biochem. Biophys. Res. Commun., 302: 95
7. Huang, T.S., Lee, C.C., Chang, A.C., Lin, S., Chao, C.C., Jou, Y.S., Chu, Y.W., Wu, C.W., and, Whang-Peng, J. 2003. Biochem. Biophys. Res. Commun., 300: 901
8. Nitiss, J.L. 2009. Nat. Rev. Cancer, 5: 338
9. Shiloh, Y. 2006. Trends Biochem. Sci., 31: 402
10. Bakkenist, C.J., and, Kastan, M.B. 2003. Nature, 421: 499
11. Shiloh, Y. 2003. Nat. Rev. Cancer, 3: 155
12. Levine, A.J. 1997. Cell, 88: 323
13. Lin, S., Huang, H.C., Chen, L.L., Lee, C.C., and, Huang, T.S. 2001. Mol. Pharmacol., 60: 768
14. Chen, Y., Su, Y.H., Wang, C.H., Wu, J.M., Chen, J.C., and, Tseng, S.H. 2005. Anticancer Res., 25: 4203
15. Venook, A.P., Papandreou, C., Furuse, J., and, de Guevara, L.L. 2010. Oncologist, 15 (Suppl. 4): 5
16. Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., and, Bonner, W.M. 1998. J. Biol. Chem., 273: 5858
17. Podhorecka, M., Skladanowski, A., Bozko, P., and, Nucleic, J. 2010. J. Nucleic Acids, 920161
18. Eastman, A. 2004. J. Cell Biochem., 91: 223
19. Masai, H., Matsumoto, S., You, Z., Yoshizawa-Sugata, N., and, Eukaryotic Oda, M. 2010. Annu. Rev. Biochem., 79: 89
20. Busino, L., Chiesa, M., Draetta, G.F., and, Donzelli, M. 2004. Oncogene, 23: 2050
21. Abraham, R.T. 2001. Genes Dev., 15: 2177
22. Bartek, J., Lukas, C., and, Lukas, J. 2004. Nat. Rev. Mol. Cell Biol., 5: 792
23. Bode, A.M., and, Dong, Z. 2004. Nat. Rev. Cancer, 4: 793
24. Cai, K., and, Dynlacht, B.D. 1998. Pro. Natl. Acad. Sci. USA, 95: 12254