Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors

Journal of Controlled Release

Volumn 162, Issue 1, 2012, Pages 218-224

  Wang, Shutao ^a,b   Shin, In Soo ^a   Hancock, Hilary ^a   Jang, Beom Su ^a   Kim, Hyung Sub ^a   Lee, Sang Myung ^a   Zderic, Vesna ^b   Frenkel, Victor ^c   Pastan, Ira ^d   Paik, Chang H ^a   Dreher, Matthew R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b The George Washington University   (United States)

^c Catholic University of America   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Binding site barrier; Monoclonal antibodies; Penetration; Pulsed HIFU; Radioimmunotherapy

Indexed keywords

BIODISTRIBUTIONS; DUTY CYCLES; HIGH INTENSITY FOCUSED ULTRASOUND; MICROVASCULAR; P-VALUES; PEAK INTENSITY; PENETRATION; PRE-TREATMENT; PULSE REPETITION FREQUENCIES; PULSED-HIFU; RADIOIMMUNOTHERAPY; SOLID TUMORS; THERAPEUTIC EFFICACY; TUMOR ACCUMULATION; TUMOR MICROENVIRONMENT; TUMOR PENETRATION; TUMOR PERIPHERY; TUMOR SIZE; VASCULAR ARCHITECTURE;

BLOOD VESSELS; MONOCLONAL ANTIBODIES; RADIOTHERAPY; SURFACE PLASMON RESONANCE; ULTRASONIC TESTING;

TUMORS;

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B3; UNCLASSIFIED DRUG; YTTRIUM 90;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; EPIFLUORESCENCE MICROSCOPY; HIGH INTENSITY FOCUSED ULTRASOUND; IMAGE ANALYSIS; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; SURVIVAL; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE, TUMOR; HUMANS; IMMUNOCONJUGATES; MICE; MICE, NUDE; NEOPLASMS; RADIOIMMUNOTHERAPY; TRANSPLANTATION, HETEROLOGOUS; ULTRASONIC THERAPY; YTTRIUM RADIOISOTOPES;

EID: 84864708455     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.06.025     Document Type: Article

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