Arecoline improves vascular endothelial function in high fructose-fed rats via increasing cystathionine-γ-lyase expression and activating K ATP channels

Acta Pharmacologica Sinica

Volumn 33, Issue 8, 2012, Pages 1023-1029

  Ling, Hong Yan ^a   Wang, Guang ^a   Zhang, Wei ^b   Li, Xing ^a   Zhou, Shou Hong ^a   Hu, Bi ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b Department of Chemistry and Life Science   (China)

Author keywords

arecoline; betel quid chewing; cystathionine lyase; diabetes mellitus; endothelium dependent vasorelaxation; glibenclamide; high fructose fed rat; propargylglycine; vascular endothelial dysfunction

Indexed keywords

ARECOLINE; CYSTATHIONINE GAMMA LYASE; FRUCTOSE; GLIBENCLAMIDE; GLUCOSE; INSULIN; POTASSIUM CHANNEL; PROPARGYLGLYCINE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; BETEL NUT; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG MEGADOSE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LOW DRUG DOSE; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORACIC AORTA; TREATMENT DURATION; VASCULAR ENDOTHELIUM; VASCULAR RING; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; WISTAR RAT;

ANIMALS; AORTA, THORACIC; ARECOLINE; CYSTATHIONINE GAMMA-LYASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FRUCTOSE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KATP CHANNELS; MALE; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR;

EID: 84864708383     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.63     Document Type: Article

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