Effects of arecoline on adipogenesis, lipolysis, and glucose uptake of adipocytes-A possible role of betel-quid chewing in metabolic syndrome

Toxicology and Applied Pharmacology

Volumn 245, Issue 3, 2010, Pages 370-377

  Hsu, Hsin Fen ^a   Tsou, Tsui Chun ^a   Chao, How Ran ^b   Shy, Cherng Gueih ^c,d   Kuo, Ya Ting ^a   Tsai, Feng Yuan ^a   Yeh, Szu Ching ^a   Ko, Ying Chin ^a,e  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c PINGTUNG CHRISTIAN HOSPITAL   (Taiwan)

^d TAJEN UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adipocytes; Adipogenesis; Arecoline; Betel quid; Glucose uptake; Lipolysis; Metabolic syndrome

Indexed keywords

ADENYLATE CYCLASE; ARECOLINE; FAT DROPLET; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ADIPOCYTE; ADIPOGENESIS; ADULT; AGED; ANIMAL CELL; ARTICLE; BETEL NUT; CELL DIFFERENTIATION; CELL METABOLISM; CONTROLLED STUDY; DIABETOGENESIS; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; IN VITRO STUDY; INSULIN RESISTANCE; LIPOLYSIS; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; MOUSE; NONHUMAN; PROADIPOCYTE; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

3T3-L1 CELLS; ADENYLATE CYCLASE; ADIPOCYTES; ADIPOGENESIS; ADULT; AGED; ANIMALS; ARECA; ARECOLINE; BIOLOGICAL TRANSPORT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLYCEROL; HUMANS; HYPERLIPIDEMIAS; INSULIN; LIPOLYSIS; MALE; MASTICATION; METABOLIC SYNDROME X; MICE; MIDDLE AGED; NUTS; TIME FACTORS; TRIGLYCERIDES;

ARECA CATECHU; PIPER BETEL;

EID: 77952951095     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.04.008     Document Type: Article

References (50)

1. Arner P. Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract. Res. Clin. Endocrinol. Metab. 2005, 19:471-482.
2. Ascaso J.F., Real J.T., Carmena R. Insulin resistance and familial dyslipidaemias. Diabetes Obes. Metab. 1999, 1:323-330.
3. Benjamin A.L. Community screening for diabetes in the National Capital District, Papua New Guinea: is betelnut chewing a risk factor for diabetes?. P. N. G. Med. J. 2001, 44:101-107.
4. Bergman R.N., Van Citters G.W., Mittelman S.D., Dea M.K., Hamilton-Wessler M., Kim S.P., Ellmerer M. Central role of the adipocyte in the metabolic syndrome. J. Investig. Med. 2001, 49:119-126.
5. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997, 46:3-10.
6. Boucher B.J., Mannan N. Metabolic effects of the consumption of Areca catechu. Addict. Biol. 2002, 7:103-110.
7. Boucher B.J., Ewen S.W., Stowers J.M. Betel nut (Areca catechu) consumption and the induction of glucose intolerance in adult CD1 mice and in their F1 and F2 offspring. Diabetologia 1994, 37:49-55.
8. Carmen G.Y., Victor S.M. Signalling mechanisms regulating lipolysis. Cell. Signal. 2006, 18:401-408.
9. Chang Y.C., Tai K.W., Cheng M.H., Chou L.S., Chou M.Y. Cytotoxic and non-genotoxic effects of arecoline on human buccal fibroblasts in vitro. J. Oral Pathol. Med. 1998, 27:68-71.
10. Chang M.C., Ho Y.S., Lee P.H., Chan C.P., Lee J.J., Hahn L.J., Wang Y.J., Jeng J.H. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 2001, 22:1527-1535.
11. Chang W.C., Hsiao C.F., Chang H.Y., Lan T.Y., Hsiung C.A., Shih Y.T., Tai T.Y. Betel nut chewing and other risk factors associated with obesity among Taiwanese male adults. Int. J. Obes. (Lond.) 2006, 30:359-363.
12. Chang E.E., Miao Z.F., Lee W.J., Chao H.R., Li L.A., Wang Y.F., Ko Y.C., Tsai F.Y., Yeh S.C., Tsou T.C. Arecoline inhibits the 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1A1 activation in human hepatoma cells. J. Hazard. Mater. 2007, 146:356-361.
13. Chen T.H., Chiu Y.H., Boucher B.J. Transgenerational effects of betel-quid chewing on the development of the metabolic syndrome in the Keelung Community-based Integrated Screening Program. Am. J. Clin. Nutr. 2006, 83:688-692.
14. Giri S., Idle J.R., Chen C., Zabriskie T.M., Krausz K.W., Gonzalez F.J. A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Chem. Res. Toxicol. 2006, 19:818-827.
15. Green H., Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 1975, 5:19-27.
16. Gregoire F.M., Smas C.M., Sul H.S. Understanding adipocyte differentiation. Physiol. Rev. 1998, 78:783-809.
17. Guh J.Y., Chuang L.Y., Chen H.C. Betel-quid use is associated with the risk of the metabolic syndrome in adults. Am. J. Clin. Nutr. 2006, 83:1313-1320.
18. Gupta P.C., Warnakulasuriya S. Global epidemiology of areca nut usage. Addict. Biol. 2002, 7:77-83.
19. Harmon A.W., Paul D.S., Patel Y.M. MEK inhibitors impair insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 2004, 287:E758-E766.
20. Harvey W., Scutt A., Meghji S., Canniff J.P. Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. Arch. Oral Biol. 1986, 31:45-49.
21. Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem. Soc. Trans. 2003, 31:1120-1124.
22. Betel-quid and areca-nut chewing. Lyon: International Agency for Research on Cancer 1985, vol. 37:141-202. IARC, International Agency for Research on Cancer, Lyon.
23. Betel-quid and areca-nut chewing and some areca-nut-derived nitrosamines. Lyon: International Agency for Research on Cancer 2004, vol. 85:230-239. IARC, International Agency for Research on Cancer, Lyon.
24. Jeng J.H., Lan W.H., Hahn L.J., Hsieh C.C., Kuo M.Y. Inhibition of the migration, attachment, spreading, growth and collagen synthesis of human gingival fibroblasts by arecoline, a major areca alkaloid, in vitro. J. Oral Pathol. Med. 1996, 25:371-375.
25. Jeng J.H., Chang M.C., Hahn L.J. Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. Oral Oncol. 2001, 37:477-492.
26. Jeng J.H., Wang Y.J., Chiang B.L., Lee P.H., Chan C.P., Ho Y.S., Wang T.M., Lee J.J., Hahn L.J., Chang M.C. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 2003, 24:1301-1315.
27. Juan C.C., Chang C.L., Lai Y.H., Ho L.T. Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 2005, 288:E1146-E1152.
28. Ko Y.C., Chiang T.A., Chang S.J., Hsieh S.F. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. J. Oral Pathol. Med. 1992, 21:261-264.
29. Ko Y.C., Huang Y.L., Lee C.H., Chen M.J., Lin L.M., Tsai C.C. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. J. Oral Pathol. Med. 1995, 24:450-453.
30. Langin D. Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacol. Res. 2006, 53:482-491.
31. Langin D. Control of fatty acid and glycerol release in adipose tissue lipolysis. C. R. Biol. 2006, 329:598-607. (discussion 653-595).
32. May J.S., Prince A.M., Lyle R.E., McGehee R.E. Antisense suppression of p107 inhibits 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 2001, 283:837-842.
33. Muoio D.M., Newgard C.B. Obesity-related derangements in metabolic regulation. Annu. Rev. Biochem. 2006, 75:367-401.
34. Owen P.L., Martineau L.C., Caves D., Haddad P.S., Matainaho T., Johns T. Consumption of guava (Psidium guajava L) and noni (Morinda citrifolia L) may protect betel quid-chewing Papua New Guineans against diabetes. Asia Pac. J. Clin. Nutr. 2008, 17:635-643.
35. Paul D.S., Harmon A.W., Winston C.P., Patel Y.M. Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes. Biochem. J. 2003, 376:625-632.
36. Pellegrini M., Marchei E., Rossi S., Vagnarelli F., Durgbanshi A., Garcia-Algar O., Vall O., Pichini S. Liquid chromatography/electrospray ionization tandem mass spectrometry assay for determination of nicotine and metabolites, caffeine and arecoline in breast milk. Rapid Commun. Mass Spectrom. 2007, 21:2693-2703.
37. Pichini S., Pellegrini M., Pacifici R., Marchei E., Murillo J., Puig C., Vall O., Garcia-Algar O. Quantification of arecoline (areca nut alkaloid) in neonatal biological matrices by high-performance liquid chromatography/electrospray quadrupole mass spectrometry. Rapid Commun. Mass Spectrom. 2003, 17:1958-1964.
38. Rangwala S.M., Lazar M.A. Transcriptional control of adipogenesis. Annu. Rev. Nutr. 2000, 20:535-559.
39. Rosen E.D., Spiegelman B.M. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 2000, 16:145-171.
40. Shakur Y., Holst L.S., Landstrom T.R., Movsesian M., Degerman E., Manganiello V. Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog. Nucleic Acid Res. Mol. Biol. 2001, 66:241-277.
41. Strickland S.S., Veena G.V., Houghton P.J., Stanford S.C., Kurpad A.V. Areca nut, energy metabolism and hunger in Asian men. Ann. Hum. Biol. 2003, 30:26-52.
42. Tsai J.F., Chuang L.Y., Jeng J.E., Ho M.S., Hsieh M.Y., Lin Z.Y., Wang L.Y. Betel quid chewing as a risk factor for hepatocellular carcinoma: a case-control study. Br. J. Cancer 2001, 84:709-713.
43. Tsai C.H., Chou M.Y., Chang Y.C. The up-regulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis. J. Oral Pathol. Med. 2003, 32:146-153.
44. Tsou T.C., Yeh S.C., Tsai F.Y., Chang L.W. The protective role of intracellular GSH status in the arsenite-induced vascular endothelial dysfunction. Chem. Res. Toxicol. 2004, 17:208-217.
45. Tung T.H., Chiu Y.H., Chen L.S., Wu H.M., Boucher B.J., Chen T.H. A population-based study of the association between areca nut chewing and type 2 diabetes mellitus in men (Keelung Community-based Integrated Screening programme No. 2). Diabetologia 2004, 47:1776-1781.
46. Wang L.Y., You S.L., Lu S.N., Ho H.C., Wu M.H., Sun C.A., Yang H.I., Chien-Jen C. Risk of hepatocellular carcinoma and habits of alcohol drinking, betel quid chewing and cigarette smoking: a cohort of 2416 HBsAg-seropositive and 9421 HBsAg-seronegative male residents in Taiwan. Cancer Causes Control 2003, 14:241-250.
47. Winstock A. Areca nut-abuse liability, dependence and public health. Addict. Biol. 2002, 7:133-138.
48. Wu M.T., Lee Y.C., Chen C.J., Yang P.W., Lee C.J., Wu D.C., Hsu H.K., Ho C.K., Kao E.L., Lee J.M. Risk of betel chewing for oesophageal cancer in Taiwan. Br. J. Cancer 2001, 85:658-660.
49. Yang J., Clark A.E., Kozka I.J., Cushman S.W., Holman G.D. Development of an intracellular pool of glucose transporters in 3T3-L1 cells. J. Biol. Chem. 1992, 267:10393-10399.
50. Yen A.M., Chiu Y.H., Chen L.S., Wu H.M., Huang C.C., Boucher B.J., Chen T.H. A population-based study of the association between betel-quid chewing and the metabolic syndrome in men. Am. J. Clin. Nutr. 2006, 83:1153-1160.