Optimization of IGF-1R SPECT/CT imaging using 111in-labeled F(ab)2 and Fab fragments of the monoclonal antibody R1507

Molecular Pharmaceutics

Volumn 9, Issue 8, 2012, Pages 2314-2321

  Heskamp, Sandra ^a   Van Laarhoven, Hanneke W M ^a,b   Molkenboer Kuenen, Janneke D M ^a   Bouwman, Wilbert H ^a   Van Der Graaf, Winette T A ^a   Oyen, Wim J G ^a   Boerman, Otto C ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

antibody; breast cancer; F(ab?)2; Fab; IGF 1R; SPECT

Indexed keywords

IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN F(AB')2 FRAGMENT INDIUM 111; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN F(AB) FRAGMENT INDIUM 111; INDIUM 111; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY R1507; MONOCLONAL ANTIBODY R1507 IMMUNOGLOBULIN G INDIUM 111; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG DISTRIBUTION; EX VIVO STUDY; GENE TARGETING; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; ANTIBODIES, MONOCLONAL; BREAST NEOPLASMS; CELL LINE, TUMOR; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MICE, NUDE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84864683719     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300232n     Document Type: Article

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