Efficient microbubble- and ultrasound-mediated plasmid DNA delivery into a specific rat liver lobe via a targeted injection and acoustic exposure using a novel ultrasound system

Molecular Pharmaceutics

Volumn 9, Issue 8, 2012, Pages 2187-2196

  Song, Shuxian ^a   Noble, Misty ^a   Sun, Samuel ^a   Chen, Liping ^a   Brayman, Andrew A ^b   Miao, Carol H ^a,b,c  

^a SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^b Applied Physics Laboratory   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

acoustic cavitation; nonviral gene delivery; ultrasound induced bioeffects; ultrasound targeted microbubble destruction technique; vascular and cellular permeabilization

Indexed keywords

AMINOTRANSFERASE; LUCIFERASE; PERFLUTREN; PLASMID DNA;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; GENE DELIVERY SYSTEM; GENE EXPRESSION; LIVER INJURY; MALE; MICROBUBBLE; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT; ULTRASOUND;

ANIMALS; GENE TRANSFER TECHNIQUES; LIVER; MALE; MICROBUBBLES; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; ULTRASONICS;

EID: 84864681935     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300037t     Document Type: Article

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