The molecular anatomy of human Hsp60 and its similarity with that of bacterial orthologs and acetylcholine receptor reveal a potential pathogenetic role of anti-chaperonin immunity in myasthenia gravis

Cellular and Molecular Neurobiology

Volumn 32, Issue 6, 2012, Pages 943-947

  Marino Gammazza, Antonella ^a,b   Bucchieri, Fabio ^a,b   Grimaldi, Luigi M E ^c   Benigno, Arcangelo ^a   Conway De MacArio, Everly ^d   MacArio, Alberto J L ^b,d   Zummo, Giovanni ^a   Cappello, Francesco ^a,b  

^a UNIVERSITY OF PALERMO   (Italy)

^b Istituto Euro Mediterraneo di Scienza e Tecnologia IEMEST   (Italy)

^c Fondazione Istituto San Raffaele G Giglio   (Italy)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; Molecular mimicry; Neuromuscular disorder; Shared epitopes

Indexed keywords

CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR ALPHA1 SUBUNIT; EPITOPE; HEAT SHOCK PROTEIN 60; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNITY; CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA PNEUMONIAE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLAMMATION; MYASTHENIA GRAVIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CHAPERONIN 60; HUMANS; IMMUNITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYASTHENIA GRAVIS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CHOLINERGIC; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); CHLAMYDIA TRACHOMATIS; CHLAMYDOPHILA PNEUMONIAE; EUKARYOTA; PROKARYOTA;

EID: 84864670458     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-011-9789-8     Document Type: Article

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