Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging

FEBS Letters

Volumn 584, Issue 8, 2010, Pages 1549-1552

  Hu, Haiyan ^a   Zhang, Rui ^a   Zhang, Yongfang ^a   Xia, Zongqin ^a   Hu, Yaer ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Antisense oligonucleotide; CHO cells transfected with M1 receptor gene (CHOm1 cell); Cyclic AMP response element binding protein (CREB); Muscarinic acetylcholine receptor subtype 1 (M1 receptor); Phosphorylated CREB (pCREB); Sarsasapogenin (ZMS)

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIMETHYL SULFOXIDE; HETERODIMER; MUSCARINIC M1 RECEPTOR; SARSASAPOGENIN;

ANIMAL CELL; ARTICLE; CELL AGING; CHO CELL; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HYPOTHESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RECEPTOR DENSITY; RECEPTOR GENE; RECEPTOR UPREGULATION;

ANIMALS; BASE SEQUENCE; CELL AGING; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIMETHYL SULFOXIDE; KINETICS; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOPROTEINS; RECEPTOR, MUSCARINIC M1; SPIROSTANS; UP-REGULATION;

EID: 77951275404     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.03.006     Document Type: Article

References (23)

1. Conkright M.D., Canettieri G., Screaton R., Guzman E., Miraglia L., Hogenesch J.B., Montminy M. Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol. Cell. 2003, 11:1101-1108.
2. Tardito D., Perez J., Tiraboschi E., Musazzi L., Racagni G., Popoli M. Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol. Rev. 2006, 58:115-134.
3. Mantamadiotis T., Lemberger T., Bleckmann S.C., Kern H., Kretz O., Martin Villalba A., Tronche F., Kellendonk C., Gau D., Kapfhammer J., Otto C., Schmid W., Schütz G. Disruption of CREB function in brain leads to neurodegeneration. Nat. Genet. 2002, 31:47-54.
4. Mouravlev A., Dunning J., Young D., During M.J. Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats. Proc. Natl. Acad. Sci. USA 2006, 21(103):4705-4710.
5. Shaywitz A.J., Greenberg M.E. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 1999, 68:821-861.
6. Chrivia J.C., Kwok R.P., Lamb N., Hagiwara M., Montminy M.R., Goodman R.H. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 1993, 365:855-859.
7. Pepitoni S., Wood I.C., Buckley N.J. Structure of the m1 muscarinic acetylcholine receptor gene and its promoter. J. Biol. Chem. 1997, 272:17112-17117.
8. Klett C.P., Bonner T.I. Identification and characterization of the rat M1 muscarinic receptor promoter. J. Neurochem. 1999, 72:900-909.
9. Fung H., Liu P.F., Demple B. ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Mol. Cell. Biol. 2007, 27:8834-8847.
10. Shaulian E., Karin M. AP-1 in cell proliferation and survival. Oncogene 2001, 20:2390-2400.
11. Hu Y., Xia Z., Sun Q., Orsi A., Rees D. A new approach to the pharmacological regulation of memory: sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models. Brain Res. 2005, 1060:26-39.
12. Buckley N.J., Bonner T.I., Buckley C.M., Brann M.R. Antagonist binding properties of five cloned muscarinic receptor expressed in CHO-K1 cells. Mol. Pharmacol. 1989, 35:469-476.
13. Guzowski J.F., McGaugh J.L. Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training. Proc. Natl. Acad. Sci. USA 1997, 94:2693-2698.
14. Johannessen M., Delghandi M.P., Moens U. What turns CREB on?. Cell Signal. 2004, 16:1211-12127.
15. Kurreck J. Antisense technologies. Eur. J. Biochem. 2003, 270:1628-1644.
16. Bennett C.F., Swayze E.E. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 2010, 50:259-293.
17. Won J., Silva A.J. Molecular and cellular mechanisms of memory allocation in neuronetworks. Neurobiol. Learn Mem. 2008, 89:285-292.
18. Rix U., Superti-Furga G. Target profiling of small molecules by chemical proteomics. Nat. Chem. Biol. 2009, 5:616-624.
19. Hu Y.E., Sun Q.X., Xia Z.Q. The effect of ZMS, an active component of Zhimu, on NGF and BDNF onm brains of aged rats. Chinese Pharmacological Bulletin. 2003, 19:149-151.
20. Murer M.G., Yan Q., Raisman-vozan R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog. Neurobiol. 2001, 63:71-124.
21. Fumagalli F., Racagni G., Riva M.A. The expanding role of BDNF: a therapeutic target for Alzheimer's disease?. Pharmacogenomics J. 2006, 6:8-15.
22. Arancibia S., Silhol M., Mouliere F., Meffre J., Hollinger I., Maurice T., Tapia-Arancibia L. Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol. Dis. 2008, 31:316-326.
23. Nagahara A.H., Merril D.A., Coppola G., Tsukada S., Schroeder B.E., Shaked G.M., Wang L., Blesch A., Kim A., Gonner J.M., Rockenstein E., Chao M.V., Koo E.H., Geschwind D., Masliah E., Chiba A.A., Tuszynski M.H. Neuroprotective effects of brain derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat. Med. 2009, 15:331-337.