Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition

Nature Reviews Rheumatology

Volumn 8, Issue 8, 2012, Pages 441-442

  Lafyatis, Robert ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICKKOPF 1 PROTEIN; ENDOTHELIN 1; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; WNT1 PROTEIN; WNT10B PROTEIN; WNT3 PROTEIN; WNT3A PROTEIN;

CELL DIFFERENTIATION; CELL STIMULATION; DOWN REGULATION; FIBROSIS; GENE; HUMAN; LIPOATROPHY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; SHORT SURVEY; SIGNAL TRANSDUCTION; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; UPREGULATION; WNT GENE;

ANIMALS; DISEASE MODELS, ANIMAL; FIBROSIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; SCLERODERMA, SYSTEMIC; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84864631207     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2012.99     Document Type: Short Survey

References (10)

1. Akhmetshina, A. et al. Activation of canonical Wnt signalling is required for TGF β-mediated fibrosis. Nat. Commun. 3, 735 (2012
2. Nishita, M. et al. Interaction between Wnt and TGF β signalling pathways during formation of Spemann's organizer. Nature 403, 781-785 (2000
3. Lemaire, R. et al. Antagonistic effect of the matricellular signaling protein CCN3 on TGF β and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J. Invest. Dermatol. 130, 1514-1523 (2010
4. Wei, J. et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma? Arthritis Rheum. 63, 1707-1717 (2011
5. Brack, A. S. et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 317, 807-810 (2007
6. Wei, J. et al. Wnt/β-catenin signaling is hyperactivated in systemic sclerois and induces smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum. http://dx.doi.org/10.1002/art.34424.
7. Bayle, J. et al. Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: Role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J. Invest. Dermatol. 128, 871-881 (2008
8. van Amerongen, R. and Nusse, R. Towards an integrated view of Wnt signaling in development. Development 136, 3205-3214 (2009
9. Lam, A. P. et al. Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am. J. Respir. Cell Mol. Biol. 45, 915-922 (2011
10. Farina, G., Lafyatis, D., Lemaire, R. and Lafyatis, R. A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 62, 580-588 (2010)