A novel resistance mechanism to triclosan that suggests horizontal gene transfer and demonstrates a potential selective pressure for reduced biocide susceptibility in clinical strains of Staphylococcus aureus

International Journal of Antimicrobial Agents

Volumn 40, Issue 3, 2012, Pages 210-220

  Ciusa, Maria Laura ^a   Furi, Leonardo ^a   Knight, Daniel ^b   Decorosi, Francesca ^c   Fondi, Marco ^c   Raggi, Carla ^d   Coelho, Joana Rosado ^e   Aragones, Luis ^f   Moce, Laura ^f   Visa, Pilar ^f   Freitas, Ana Teresa ^e   Baldassarri, Lucilla ^d   Fani, Renato ^c   Viti, Carlo ^c   Orefici, Graziella ^d   Martinez, Jose Luis ^g   Morrissey, Ian ^b   Oggioni, Marco Rinaldo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b Quotient Bioresearch Ltd   (United Kingdom)

^c UNIVERSITY OF FLORENCE   (Italy)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e Eurofins Medinet Inc   (Germany)

^f UNIVERSITY OF LISBON   (Portugal)

^g CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Biocide; Cross resistance; FabI; Horizontal gene transfer; Resistance; Triclosan

Indexed keywords

BIOCIDE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADPH); TRICLOSAN;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG CONCENTRATION; ENOYL ACYL CARRIER PROTEIN REDUCTASE GENE; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SELECTION; GENOTYPE; HORIZONTAL GENE TRANSFER; IN VITRO SELECTION; IN VITRO STUDY; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SELECTIVE PRESSURE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS HAEMOLYTICUS; STRAIN IDENTIFICATION;

DISINFECTANTS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENE TRANSFER, HORIZONTAL; GENOTYPE; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION; PHENOTYPE; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TRICLOSAN;

EID: 84864624743     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.04.021     Document Type: Article

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