Commentary: The carboxyl-terminal Crk SH3 domain: Regulatory strategies and new perspectives

FEBS Letters

Volumn 586, Issue 17, 2012, Pages 2615-2618

  Sriram, Ganapathy ^a   Birge, Raymond B ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Carboxyl terminal SH3 domain; Crk; Oncogene

Indexed keywords

CT10 REGULATOR OF KINASE PROTEIN; PROTEIN SH3; REGULATOR PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; HUMAN; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL MOVEMENT; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-CRK; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TYROSINE;

EID: 84864601765     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2012.04.040     Document Type: Review

References (22)

1. B.J. Mayer, M. Hamaguchi, and H. Hanafusa A novel viral oncogene with structural similarity to phospholipase C Nature 332 6161 1988 272 275
2. B.J. Mayer, and H. Hanafusa Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity Proc. Natl. Acad. Sci. USA 87 7 1990 2638 2642
3. M. Matsuda Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins Science 248 4962 1990 1537 1539
4. R.B. Birge Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts Mol. Cell. Biol. 13 8 1993 4648 4656
5. B.S. Knudsen Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins EMBO J. 14 10 1995 2191 2198
6. N. Li Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling Nature 363 6424 1993 85 88
7. V. Muralidharan Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II Biochemistry 45 29 2006 8874 8884
8. M.K. Rosen Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein Nature 374 6521 1995 477 479
9. S.M. Feller, B. Knudsen, and H. Hanafusa C-Abl kinase regulates the protein binding activity of c-Crk EMBO J. 13 10 1994 2341 2351
10. Y. Kobashigawa Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK Nat. Struct. Mol. Biol. 14 6 2007 503 510
11. P. Sarkar Structural basis for regulation of the Crk signaling protein by a proline switch Nat. Chem. Biol. 7 1 2011 51 57
12. P. Sarkar Proline cis-trans isomerization controls autoinhibition of a signaling protein Mol. Cell 25 3 2007 413 426
13. G. Sriram Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation Oncogene 30 46 2011 4645 4655
14. H. Park Regulation of Btk function by a major autophosphorylation site within the SH3 domain Immunity 4 5 1996 515 525
15. L.M. Morrogh The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro Eur. J. Immunol. 29 7 1999 2269 2279
16. M.A. Meyn 3rd Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity J. Biol. Chem. 281 41 2006 30907 30916
17. S. Chen Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core J. Mol. Biol. 383 2 2008 414 423
18. R. Janostiak Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness Mol. Biol. Cell 22 22 2011 4256 4267
19. W. Luo Global impact of oncogenic Src on a phosphotyrosine proteome J. Proteome Res. 7 8 2008 3447 3460
20. M. Harkiolaki Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2 Structure 17 6 2009 809 822
21. M. Harkiolaki Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76 EMBO J. 22 11 2003 2571 2582
22. Jankowski, W. et al. (2012) Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat. Chem. Biol. http://dx.doi.org/10. 1038/nchembio.954. [Epub ahead of print].