Nanosecond pulsed electric field ablation of hepatocellular carcinoma

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2011, Pages 6861-6865

  Beebe, Stephen J ^a   Chen, Xinhua ^a,b   Liu, Jie A ^a   Schoenbach, Karl H ^a  

^a OLD DOMINION UNIVERSITY   (United States)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE-3; CASPASES; CLINICAL TRIAL; EFFECTIVE THERAPY; ELECTRIC FIELD STRENGTH; HEPATOCELLULAR CARCINOMA; HUMAN MODEL; IN-VITRO; IN-VIVO; NANOSECOND PULSED ELECTRIC FIELDS; NONTHERMAL; ORTHOTOPIC; PRE-CLINICAL; PULSE POWER; RAT MODEL; SKIN CANCERS;

ABLATION; DISEASES; DRUG THERAPY; RATS;

ELECTRIC FIELDS;

CASPASE 3;

ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CANCER TRANSPLANTATION; CATHETER ABLATION; ELECTRICITY; ELECTROPORATION; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METHODOLOGY; MOUSE; RAT; SKIN TUMOR; TIME; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CATHETER ABLATION; CELL LINE, TUMOR; ELECTRICITY; ELECTROPORATION; FEMALE; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; RATS; SKIN NEOPLASMS; TIME FACTORS;

EID: 84864595994     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2011.6091692     Document Type: Conference Paper

References (20)

1. S. L. Friedman, "Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver," Physiol Rev., vol. 88, pp.125-172, Jan. 2008.
2. T. Takehara, T. Tatsumi, T. Suzuki, E.B. Rucker 3rd, L. Hennighausen, M. Jinushi, et al., "Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses," Gastroenterology, vol. 127, pp. :1189-1197, Oct. 2004.
3. B.Vick, A. Weber, T. Urbanik, T. Maass, A. Teufel, P.H. Krammer, et al., "Knockout of myeloid cell leukemia-1 induces liver damage and increases apoptosis susceptibility of murine hepatocytes," Hepatology, vol. 49, pp. 627-636, Feb. 2009.
4. H. Malhi, M.E. Guicciardi, G.J. Gores, "Hepatocyte death: a clear and present danger," Physiol Rev., vol. 90, pp. 1165-1194, Jul. 2010.
5. D. Hanahan, R.A. Weinberg, "Hallmarks of cancer: the next generation," Cell, vol. 4, pp. 646-674, Mar. 2011.
6. C.H. Cha, M.W. Saif, B.H. Yamane, S.M. Weber, "Hepatocellular carcinoma: current management," Curr Probl Surg., vol. 47, pp. 10-67, Jan. 2010
7. Center for Disease Control. Morbidity and Mortality Weekly Report, May 7, 2010.
8. J. M. Llovet, J. Fuster, J. Bruix. "The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma", Liver Transpl., vol. 10, pp. S115-120, Feb. 2004.
9. J. M. Llovet, R. Vilana, C. Brú, L. Bianchi, J. M. Salmeron, L. Boix, S. Ganau, M. Sala, M. Pagès, C. Ayuso, M. Solé, J. Rodés, et al., "Increased risk of tumor seeding after percutaneous radiofrequency ablation for single hepatocellular carcinoma", Hepatology vol. 33, pp.1124-1129, May 2001.
10. J.F. Edd, L. Horowitz, R.V. Davalos, L.M, Mir, B. Rubinsky, "In vivo results of a new focal tissue ablation," technique: irreversible electroporation, IEEE Trans Biomed Eng., vol 53, pp.1409-1415, Jul. 2006.
11. R. Nuccitelli, U. Pliquett, X. Chen, W. Ford, J.R. Swanson, S.J. Beebe, et al., "Nanosecond pulsed electric fields cause melanomas to self-destruct," Biochem Biophys Res Commun., vol. 343, pp. 351-360. May 2006
12. X. Chen, J.F. Kolb, R.J. Swanson, K.H. Schoenbach, S.J. Beebe, "Apoptosis initiation and angiogenesis inhibition: melanoma targets for nanosecond pulsed electric fields," Pigment Cell Melanoma Res., vol. 23, pp. 554-563, Aug. 2010.
13. J.F. Kolb, X. Chen, J. Zhuang, W. Ren, N. Scully, R.J. Swanson, S.J. Beebe, K.H. Schoenbach, "Tumor treatment with nanosecond pulsed electric fields," IEEE Pulse Power Conference 2009; pg.880-885.
14. E.H. Hall, K.H. Schoenbach, S.J. Beebe, "Nanosecond pulsed electric fields induce apoptosis in p53-wildtype and p53-null HCT116 colon carcinoma cells," Apoptosis, vol. 12, pp.1721-1731, Sept. 2007.
15. W.E. Ford, W. Ren, P.F. Blackmore, K.H. Schoenbach, S.J. Beebe, "Nanosecond pulsed electric fields stimulate apoptosis without release of pro-apoptotic factors from mitochondria in B16f10 melanoma," Arch Biochem Biophys., vol. 497, pp. 82-89 May. 2010
16. W. Ren, S.J. Beebe, "An apoptosis targeted stimulus with nanosecond pulsed electric fields (nsPEFs) in E4 squamous cell carcinoma," Apoptosis, in press. Jan. 2011.
17. G. Long, P. Shires, D. Plescia, S Beebe, J. Kolb, K. H. Schoenbach, "Targeted tissue ablation with nanosecond pulses," IEEE Transactions on Biomedical Engineering, in press.
18. J.D, Yang, I. Nakamura, L.R. Roberts, "The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets", Semin Cancer Biol., vol. 21, pp. 35-43, Feb. 2011.
19. X. Chen, R. J. Swanson, J. F. Kolb, R. Nuccitelli, K. H. Schoenbach, "Histopathology of normal skin and melanomas after nanosecond pulsed electric field treatment", Melanoma Res., vol. 19, pp. 361-371, Aug. 2009.
20. M. J. McKeage, B. C. Baguley, "Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer", Cancer., vol. 116, pp. 1859-1871, Apr. 2010.