Unmet expectations: MiR-34 plays no role in p53-mediated tumor suppression in vivo

PLoS Genetics

Volumn 8, Issue 7, 2012, Pages

  Jain, Abhinav K ^a   Barton, Michelle Craig ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 34; MICRORNA 34A; MICRORNA 34B; MICRORNA 34C; PROTEIN P53; UNCLASSIFIED DRUG; MIRN34 MICRORNA, MOUSE;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CARCINOGENESIS; CELL AGING; CELL CYCLE ARREST; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE REPRESSION; HUMAN; NONHUMAN; PROTEIN FUNCTION; PROTEIN RNA BINDING; RNA ANALYSIS; ANIMAL; ANIMAL EMBRYO; CYTOLOGY; FIBROBLAST; GENETICS; METABOLISM; MOUSE; NEOPLASM;

ANIMALS; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; MICE; MICRORNAS; NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864595810     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002859     Document Type: Article

References (36)

1. Spike BT, Wahl GM, (2011) p53, stem cells, and reprogramming: tumor suppression beyond guarding the genome. Genes Cancer 2: 404-419.
2. Soussi T, (2007) p53 alterations in human cancer: more questions than answers. Oncogene 26: 2145-2156.
3. Hollstein M, Sidransky D, Vogelstein B, Harris CC, (1991) p53 mutations in human cancers. Science 253: 49-53.
4. Harvey M, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A, et al. (1993) Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet 5: 225-229.
5. Jacks T, Remington L, Williams BO, Schmitt EM, Halachmi S, et al. (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol: CB 4: 1-7.
6. Vousden KH, Prives C, (2009) Blinded by the light: the growing complexity of p53. Cell 137: 413-431.
7. Sah VP, Attardi LD, Mulligan GJ, Williams BO, Bronson RT, et al. (1995) A subset of p53-deficient embryos exhibit exencephaly. Nat Genet 10: 175-180.
8. Hu W, Feng Z, Teresky AK, Levine AJ, (2007) p53 regulates maternal reproduction through LIF. Nature 450: 721-724.
9. Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, et al. (1999) p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398: 708-713.
10. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, et al. (2000) p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404: 99-103.
11. Concepcion CP, Han Y-C, Mu P, Bonetti C, Yao E, et al. (2012) Intact p53-dependent responses in miR-34-deficient mice. PloS Genet 8: e1002792 doi:10.1371/journal.pgen.1002797.
12. Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, et al. (2007) p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17: 1298-1307.
13. He L, He X, Lim LP, de Stanchina E, Xuan Z, et al. (2007) A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134.
14. Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, et al. (2007) Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743.
15. Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, et al. (2007) Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26: 745-752.
16. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H, (2007) Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci U S A 104: 15472-15477.
17. Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, et al. (2007) Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6: 1586-1593.
18. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
19. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, et al. (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101: 2999-3004.
20. He L, He X, Lowe SW, Hannon GJ, (2007) microRNAs join the p53 network-another piece in the tumour-suppression puzzle. Nat Rev Cancer 7: 819-822.
21. Spurgers KB, Gold DL, Coombes KR, Bohnenstiehl NL, Mullins B, et al. (2006) Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem 281: 25134-25142.
22. Lee KC, Crowe AJ, Barton MC, (1999) p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Mol Cell Biol 19: 1279-1288.
23. Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, et al. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 7: 165-171.
24. Riley T, Sontag E, Chen P, Levine A, (2008) Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Bio 9: 402-412.
25. Ho J, Benchimol S, (2003) Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 10: 404-408.
26. Lin CP, Choi YJ, Hicks GG, He L, (2012) The emerging functions of the p53-miRNA network in stem cell biology. Cell Cycle 11: 2063-72.
27. Versteeg R, Caron H, Cheng NC, van der Drift P, Slater R, et al. (1995) 1p36: every subband a suppressor? Eur J Cancer 31A: 538-541.
28. Hermeking H, (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17: 193-199.
29. Hermeking H, (2007) p53 enters the microRNA world. Cancer Cell 12: 414-418.
30. Choi YJ, Lin CP, Ho JJ, He X, Okada N, et al. (2011) miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol 13: 1353-1360.
31. Krizhanovsky V, Lowe SW, (2009) Stem cells: The promises and perils of p53. Nature 460: 1085-1086.
32. Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, et al. (2012) p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol 10: e1001268 doi:10.1371/journal.pbio.1001268.
33. Leucci E, Cocco M, Onnis A, De Falco G, van Cleef P, et al. (2008) MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. J Pathol 216: 440-450.
34. Ji Q, Hao X, Zhang M, Tang W, Yang M, et al. (2009) MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS ONE 4: e6816 doi:10.1371/journal.pone.0006816.
35. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY, (2007) MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 67: 8433-8438.
36. Welch C, Chen Y, Stallings RL, (2007) MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 26: 5017-5022.