High levels of gene expression in the hepatocytes of adult mice, neonatal mice and tree shrews via retro-orbital sinus hydrodynamic injections of naked plasmid DNA

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 763-771

  Yan, Shaoduo ^a   Fu, Qiuxia ^a   Zhou, Yong ^a   Wang, Jidong ^a   Liu, Ying ^b   Duan, Xiangguo ^c   Jia, Shuaizheng ^a   Peng, Jianchun ^a   Gao, Bo ^a   Du, Juan ^a   Zhou, Qianqian ^a   Li, Yuan ^a   Wang, Xiaohui ^a   Zhan, Linsheng ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b AIR FORCE GENERAL HOSPITAL   (China)

^c NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Hydrodynamic gene delivery; Naked plasmid DNA; Neonatal mice; Retro orbital sinus; Tree shrews

Indexed keywords

GENE DELIVERY; NAKED PLASMID DNA; NEONATAL MOUSE; RETRO-ORBITAL SINUS; TREE SHREWS;

BIOMOLECULES; DISEASES; FORESTRY; GENE EXPRESSION; GENE TRANSFER; MAMMALS; TISSUE;

HYDRODYNAMICS;

LUCIFERASE; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; GENE EXPRESSION; HISTOLOGY; HYDRODYNAMICS; HYDRODYNAMICS BASED TRANSFECTION; IMMUNOHISTOCHEMISTRY; INJECTION; INJECTION SITE; LIVER DISEASE; MOUSE; NEWBORN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RETRO ORBITAL VENOUS SINUS; SCANDENTIA; TRANSGENE;

ANIMALS; ANIMALS, NEWBORN; BETA-GALACTOSIDASE; DNA; EYE; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HEPATOCYTES; INJECTIONS; LIVER; LUCIFERASES, FIREFLY; MALE; MICE; MICE, INBRED BALB C; PLASMIDS; SHREWS;

DISEASES; FORESTRY; HYDRODYNAMICS; MAMMALS; TISSUE;

EID: 84864590117     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.018     Document Type: Article

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