Psychosis Incident Cohort Outcome Study (PICOS). A multisite study of clinical, social and biological characteristics, patterns of care and predictors of outcome in first-episode psychosis. Background, methodology and overview of the patient sample

Epidemiology and Psychiatric Sciences

Volumn 21, Issue 3, 2012, Pages 281-303

  Lasalvia, A ^a   Tosato, S ^a   Brambilla, P ^b,c   Bertani, M ^a   Bonetto, C ^a   Cristofalo, D ^a   Bissoli, S ^a   De Santi, K ^a   Lazzarotto, L ^a   Zanatta, G ^a   Marrella, G ^a   Mazzoncini, R ^a   Zanoni, M ^a   Garzotto, N ^d   Dolce, C ^e   Nicolau, S ^f   Ramon, L ^g   Perlini, C ^a   Rambaldelli, G ^a   Bellani, M ^a   Tansella, M ^a   Ruggeri, M ^a   more..

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c SCIENTIFIC INSTITUTE   (Italy)

^d ULSS 20   (Italy)

^e Azienda Sanitaria Ulss 6 Vicenza   (Italy)

^f ULSS 22   (Italy)

^g ULSS 10   (Italy)

Author keywords

brain imaging; First episode psychosis; follow up study; genetics; outcome; predictors

Indexed keywords

ADOLESCENT; ADULT; AFFECTIVE PSYCHOSIS; BRAIN FUNCTION; CLINICAL ASSESSMENT; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; ENVIRONMENTAL FACTOR; FEMALE; FOLLOW UP; HEREDITY; HUMAN; ITALY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH SERVICE; METHODOLOGY; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATIENT CARE; POPULATION BASED CASE CONTROL STUDY; PREDICTIVE VALUE; PSYCHOLOGIC ASSESSMENT; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; SOCIAL ASPECT;

ADOLESCENT; ADULT; BRAIN; COHORT STUDIES; COMMUNITY MENTAL HEALTH SERVICES; DELIVERY OF HEALTH CARE; FEMALE; FOLLOW-UP STUDIES; HUMANS; ITALY; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PSYCHOTIC DISORDERS; REPRODUCIBILITY OF RESULTS; SOCIAL BEHAVIOR; YOUNG ADULT;

EID: 84864586019     PISSN: 20457960     EISSN: 20457979     Source Type: Journal    
DOI: 10.1017/S2045796012000315     Document Type: Review

References (104)

1. Addington J, Chaves A, Addington D (2006). Diagnostic stability over one year in first-episode psychosis. Schizophrenia Research 86, 71-75. (Pubitemid 44234042)
2. Alkelai A, Baum A, Carless M, Crowley J, Dasbanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, Glubb D, Karlsson R, Mill J, Sen S, Quinones MP, Vallender EJ, Verma R, Vijayan NN, Villafuerte S, Voineskos AN, Volk H, Yu L, Zimmermann P, DeLisi LE (2008). The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations. American Journal of Medical Genetic, Part B Neuropsychiatric Genetics 147B, 233-277. (Pubitemid 351355286)
3. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L (2008). Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature Genetics 40, 827-834. (Pubitemid 351913655)
4. Amaddeo F, Zambello F, Tansella M, Thornicroft G (2001). Accessibility and pathways to psychiatric care in a community-based mental health system. Social Psychiatry and Psychiatric Epidemiology 36, 500-507. (Pubitemid 33114650)
5. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorder (DSM-IV), 4th edn. APA: Washington.
6. Arango C, Moreno C, Martínez S, Parellada M, Desco M, Moreno D, Fraguas D, Gogtay N, James A, Rapoport J (2008). Longitudinal brain changes in early-onset psychosis. Schizophrenia Bulletin 34, 341-353. (Pubitemid 351323337)
7. Barnes TRE (1989). A rating scale for drug-induced akathisia. British Journal of Psychiatry 154, 672-676.
8. Bech P, Rafaelsen OJ, Kramp P, Bolwig TG (1978). The Mania Rating Scale: scale construction and inter-observer agreement. Neuropharmacology 6, 420-431.
9. Bechara A, Damasio A, Damasio H, Anderson S (1994). Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7-15.
10. Bellani M, Marzi CA, Savazzi S, Perlini C, Cerruti S, Ferro A, Marinelli V, Sponda S, Rambaldelli G, Tansella M, Brambilla P (2010). Laterality effects in schizophrenia and bipolar disorder. Experimental Brain Research 201, 339-344.
11. Bergen SE, Petryshen TL (2012). Genome-wide association studies of schizophrenia: does bigger lead to better results? Current Opinion in Psychiatry 25, 76-82.
12. Bertani M, Lasalvia A, Bonetto C, Tosato S, Cristofalo D, Bissoli S, De Santi K, Mazzoncini R, Lazzarotto L, Santi M, Sale A, Scalabrin D, Abate M, Tansella M, Ruggeri M, on behalf of PICOS-Veneto Group (2012). The influence of gender on clinical and social characteristics of patients at psychosis onset: a report from the Psychosis Incident Cohort Outcome Study (PICOS). Psychological Medicine 42, 769-782.
13. Bottlender R, Jaeger M, Groll C, Strauss A, Moeller HJ (2001). Deficit states in schizophrenia and their association with the length of illness and gender. European Archives of Psychiatry and Clinical Neuroscience 251, 272-278. (Pubitemid 34145312)
14. Bromet EJ, Naz B, Fochtmann LJ, Carlson GA, Tanenberg-Karant M (2005). Long-term diagnostic stability and outcome in recent first-episode cohort studies of schizophrenia. Schizophrenia Bulletin 31, 639-649. (Pubitemid 41253316)
15. Buchanan RW, Heinrichs DW (1989). The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Research 27, 335-350. (Pubitemid 19096791)
16. Cahn W, Hulshoff Pol HE, Lems EB, van Haren NE, Schnack HG, van der Linden JA, Schothorst PF, van Engeland H, Kahn RS (2002). Brain volume changes in first-episode schizophrenia: a 1-year follow-up study. Archives of General Psychiatry 59, 1002-1010.
17. Carpenter Jr. WT, Buchanan RW, Kirkpatrick B, Tamminga C, Wood F (1993). Strong inference, theory testing, and the neuroanatomy of schizophrenia. Archives of General Psychiatry 50, 25-831.
18. Colombo L, Sartori G, Brivio C (2002). Stima del Quoziente Intellettivo tramite l'applicazione del TIB (Test Breve di Intelligenza). Giornale Italiano di Psicologia 29, 613-637.
19. Cook EH, Scherer SW (2008). Copy-number variations associated with neuropsychiatric conditions. Nature 455, 919-923.
20. David AS, Buchanan A, Reed A, Almeida O (1992). The assessment of insight in psychosis. British Journal of Psychiatry 161, 599-602.
21. DeLisi LE, Hoff AL (2005). Failure to find progressive temporal lobe volume decreases 10 years subsequent to a first episode of schizophrenia. Psychiatry Research 138, 265-268. (Pubitemid 40602214)
22. DeLisi LE, Sakuma M, Maurizio AM, Relja M, Hoff AL (2004). Cerebral ventricular change over the first 10 years after the onset of schizophrenia. Psychiatry Research 130, 57-70. (Pubitemid 38221557)
23. DeRosse P, Funke B, Burdick KE, Lencz T, Ekholm JM, Kane JM, Kucherlapati R, Malhotra AK (2006). Dysbindin genotype and negative symptoms in schizophrenia. American Journal of Psychiatry 163, 532-534. (Pubitemid 44469399)
24. de Salvia D, Barbato A, Salvo P, Zadro F (1993). Prevalence and incidence of schizophrenic disorders in Portogruaro. An Italian case register study. Journal of Nervous and Mental Disease 181, 275-82. (Pubitemid 23343025)
25. Edwards J, McGorry PD (2002). Implementing Early Intervention in Psychosis. Martin Dunitz: London.
26. Emsley R, Chiliza B, Schoeman R (2008). Predictors of long-term outcome in schizophrenia. Current Opinion in Psychiatry 21, 173-177. (Pubitemid 351339873)
27. Estes WD, Taylor HA (1964). A detection method and probabilistic models for assessing information processing from brief visual displays. Proceedings of the National Academy of Sciences of the United States of America 52, 446-454.
28. Fearon P, Kirkbride JB, Morgan C, Dazzan P, Morgan K, Lloyd T, Hutchinson G, Tarrant J, Fung WL, Holloway J, Mallett R, Harrison G, Leff J, Jones PB, Murray RM, SOP Study Group (2006). Incidence of schizophrenia and other psychoses in ethnic minority groups: results from the MRC ÆSOP study. Psychological Medicine 36,1541-1550. (Pubitemid 44575800)
29. Foerster A, Lewis S, Owen M, Murray R (1991). Pre-morbid adjustment and personality in psychosis: effects of sex and diagnosis. British Journal of Psychiatry 158, 171-176.
30. Folstein MF, Folstein SE, McHugh PR (1975). 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12: 189-198.
31. Fowler D, Rollinson R, French P (2011). Adherence and competence assessment in studies of CBT for psychosis: current status and future directions. Epidemiology and Psychiatric Sciences 20, 121-126.
32. Friis S, Larsen TK, Melle I, Opjordsmoen S, Johannessen JO, Haahr U, Simonsen E, Rund BR, Vaglum P, McGlashan T (2003). Methodological pitfalls in early detection studies-the NPE Lecture 2002. Nordic Association for Psychiatric Epidemiology. Acta Psychiatrica Scandinavica 107, 3-9. (Pubitemid 36092237)
33. Gogtay N, Vyas NS, Testa R, Wood SJ, Pantelis C (2011). Age of onset of schizophrenia: perspectives from structural neuroimaging studies. Schizophrenia Bulletin 37, 504-513.
34. Goldberg D, Williams P (1988). A User's Guide to the General Health Questionnaire. NFER-Nelson: Windsor.
35. Grant C, Addington J, Addington D, Konnert C (2001). Social functioning in first and multiepisode schizophrenia. Canadian Journal of Psychiatry 46, 746-749. (Pubitemid 33127090)
36. Hamilton M (1960). A rating scale for depression. Journal of Neurology Neurosurgery and Psychiatry 23, 56-62.
37. Harris A, Brennan J, Anderson J, Taylor A, Sanbrook M, Fitzgerald D, Lucas S, Redoblado-Hodge A, Gomes L, Gordon E (2005). Clinical profiles, scope and general findings of the Western Sydney First Episode Psychosis Project. Australian and New Zealand Journal of Psychiatry 39, 36-43. (Pubitemid 40277433)
38. Harrison PJ, Lewis DA (2003). Neuropathology of schizophrenia. In Schizophrenia, 2nd edn (ed. SR Hirsch and DR Weinberger), pp. 310-325. Blackwell Science Ltd: Oxford.
39. Heaton RK (1981). Wisconsin Card Sorting Test Manual. Psychological Assessment Resources. Psychological Assessment Resources: Odessa, FL.
40. Ho BC, Andreasen NC, Nopoulos P, Arndt S, Magnotta V, Flaum M (2003). Progressive structural brain abnormalities and their structural relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia. Archives of General Psychiatry 60, 585-594. (Pubitemid 36682316)
41. Hox J (2002). Multilevel Analysis. Techniques and Applications. Lawrence Erlbaum Associates Inc., Publishers: Mahwah, NJ.
42. Jablensky A (2006). Subtyping schizophrenia: implications for genetic research. Molecular Psychiatry 11, 815-836. (Pubitemid 44299104)
43. Jablensky A, Sartorius N, Ernberg G, Anker M, Korten A, Cooper JE, Day R, Bertelsen A (1992). Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychological Medicine, Monograph Supplement 20, 1-97.
44. Jackson C, Bernard M, Birchwood M (2011). The efficacy of psychotherapy in reducing post-psychotic trauma. Epidemiology Psychiatric Sciences 20, 127-131.
45. Kay SR, Fiszbein A, Opler LA (1987). The Positive and Negative Syndrome Scale for schizophrenia. Schizophrenia Bulletin 13, 261-276. (Pubitemid 18039085)
46. Kirchner WK (1958). Age differences in short-term retention of rapidly changing information. Journal of Experimental Psychology 55, 352-358.
47. Larsen TK, Friis S, Haahr U, Johannessen JO, Melle I, Opjordsmoen S, Rund BR, Simonsen E, Vaglum PV, McGlashan TH (2004). Premorbid adjustment in first-episode non-affective psychosis: distinct patterns of pre-onset course. British Journal of Psychiatry 185, 108-115. (Pubitemid 39061453)
48. Lasalvia A, Ruggeri M (2007). Assessing the outcome of community-based psychiatric care: building a feed-back loop from 'real world' services research into clinical practice. Acta Psychiatrica Scandinavica 116 (Suppl. 437), 6-15. (Pubitemid 350030786)
49. Lasalvia A, Tansella M (2010). Acute in-patient care in modern, community-based mental health services. Where and how? Epidemiologia e Psichiatria Sociale 19, 275-281.
50. Lasalvia A, Bonetto C, De Santi K, Ruggeri M (2004). Patterns of clinical course in persons with mental disorders: which impact on social disability and quality of life? A longitudinal study (Italian). Epidemiologia e Psichiatria Sociale 13, 169-190.
51. Lasalvia A, Gentile B, Ruggeri M, et al. (2007). Heterogeneity of the Departments of Mental Health in the Veneto Region ten years after the National Plan 1994-96 for Mental Health. Which implication for clinical practice? Findings from the PICOS Project (Italian). Epidemiologia e Psichiatria Sociale 16, 59-70. (Pubitemid 46548578)
52. Lasalvia A, Bonetto C, Bertani M, Bissoli S, Cristofalo D, Marrella G, Ceccato E, Cremonese C, De Rossi M, Lazzarotto L, Marangon V, Morandin I, Zucchetto M, Tansella M, Ruggeri M (2009). Influence of perceived organizational factors on job burnout: survey of community mental health staff. British Journal of Psychiatry 195, 537-544.
53. Leyland AH, Goldestein H (2003). Multilevel Modeling of Health Statistics. John Wiley & Sons: New York, NY.
54. Liddle PF, Pantelis C (2003). Brain imaging in schizophrenia. In Schizophrenia, 2nd edn (ed. SR Hirsch and DR Weinberger), pp. 403-417. Blackwell Science Ltd: Oxford.
55. Little RJA, Rubin DB (2002). Statistical Analysis with Missing Data, Second edition New York: Wiley.
56. Maier W (2008). Common risk genes for affective and schizophrenic psychoses. European Archives of Psychiatry and Clinical Neuroscience 258 (Suppl. 2), 37-40. (Pubitemid 351758759)
57. Malla A, Payne J (2005). First-episode psychosis: psychopathology, quality of life, and functional outcome. Schizophrenia Bulletin 31, 650-671. (Pubitemid 41253317)
58. Malla A, Norman RM (2006). The Canadian National Outcomes Study in Schizophrenia-Preface. Acta Psychiatrica Scandinavica 113 (Suppl. 430), 3.
59. Malla AK, Takhar JJ, Norman RM, Manchanda R, Cortese L, Haricharan R, Verdi M, Ahmed R (2002). Negative symptoms in first episode non-affective psychosis. Acta Psychiatrica Scandinavica 105, 431-439. (Pubitemid 34680814)
60. Marzi CA (1999). The Poffenberger paradigm: a first, simple, behavioural tool to study interhemispheric transmission in humans. Brain Research Bulletin 50, 421-422.
61. Maxwell E (1992). Manual for the Family Interview for Genetics Studies. Clinical Neurogenetics Branch, Intramural Research Program, National Institute of Mental Health: Bethesda, MD.
62. McCrone P, Leese M, Thornicroft G, Schene A, Knudsen HC, Vazquez Barquero JL, Lasalvia A, Padfield S, White IR, Griffiths G, the EPSILON Study Group (2000). The reliability of the Camberwell Assessment of Need-European Version. EPSILON Study 6. British Journal of Psychiatry 177 (Suppl. 39), 34-40.
63. McGlashan TH, Carpenter Jr WT, Bartko JJ (1988). Issues of design and methodology in long-term followup studies. Schizophrenia Bulletin 14, 569-574. (Pubitemid 19129695)
64. McGorry PD, Krstev H, Harrigan S (2000). Early detection and treatment delay: implications for outcome in early psychosis. Current Opinion in Psychiatry 13, 37-43. (Pubitemid 30071773)
65. Menezes NM, Arenovich T, Zipursky RB (2006). A systematic review of longitudinal outcome studies of first-episode psychosis. Psychological Medicine 36, 1349-1362. (Pubitemid 44355971)
66. Morgan C, Dazzan P, Morgan K, Jones P, Harrison G, Leff J, Murray R, Fearon P, SOP Study Group (2006). First episode psychosis and ethnicity: initial findings from the SOP study. World Psychiatry 5, 40-46.
67. Moritz S, Lambert M, Andresen B, Bothern A, Naber D, Krausz M (2001). Subjective cognitive dysfunction in first-episode and chronic schizophrenic patients. Comprehensive Psychiatry 42, 213-216. (Pubitemid 32416488)
68. Moritz S, Andresen B, Perro C, Schickel M, Kraus M, Naber D, PERSIST Study Group (2002). Neurocognitive performance in first episode and chronic schizophrenic patients. European Archives of Psychiatry and Clinical Neuroscience 252, 33-37. (Pubitemid 36056690)
69. Mueser KT, Nishith P, Tracy JI, DeGirolamo J, Molinaro M. (1995). Expectations and motives for substance use in schizophrenia. Schizophrenia Bulletin 21, 367-378.
70. Nasrallah H, Tandon R, Keshavan M (2011). Beyond the facts in schizophrenia: closing the gaps in diagnosis, pathophysiology, and treatment. Epidemiology and Psychiatric Sciences 20, 317-327.
71. Nelson HE (1982). National Adult Heading Test (NART): Test Manual. NFER-Nelson: Windsor.
72. Norman RM, Malla AK (2001). Duration of untreated psychosis: a critical examination of the concept and its importance. Psychological Medicine 31, 381-400. (Pubitemid 32294037)
73. Nuechterlein KH (1991). Vigilance in schizophrenia and related disorders. In Handbook of Schizophrenia. Vol. 5: Neuropsychology, Psychophysiology and Information Processing (ed. SR Seinhauer, JH Gruzelier and J Zubin), pp. 397-433. Elsevier Science Publisher: New York, NY.
74. Onwumere J, Bebbington P, Kuipers E (2011). Family interventions in early psychosis: specificity and effectiveness. Epidemiology Psychiatric Sciences 20, 113-119.
75. Pantelis C, Yücel M, Wood SJ, Velakoulis D, Sun D, Berger G, Stuart GW, Yung A, Phillips L, McGorry PD (2005). Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia. Schizophrenia Bulletin 31, 672-696. (Pubitemid 41253318)
76. Papagno C, Cappa SF, Capitani E, Forelli A, Garavaglia G, Laiacona M, Capitani E, Vallar G (1995). La comprensione non letterale del linguaggio: taratura di un test di comprensione di metafore e di espressioni idiomatiche. Archivio di Psicologia, Neurologia e Psichiatria 56, 402-420. (Pubitemid 126031849)
77. Parker G, Tupling H, Brown LB (1979). A parental bonding instrument. British Journal of Medical Psychology 52, 1-10. (Pubitemid 9171341)
78. Price G, Cercignani M, Bagary MS, Barnes TR, Barker GJ, Joyce EM, Ron MA (2006). A volumetric MRI and magnetization transfer imaging follow-up study of patients with first-episode schizophrenia. Schizophrenia Research 87, 100-108. (Pubitemid 44428132)
79. Priebe S, Huxley P, Knight S, Evans S (1999). Application and results of the Manchester Short Assessment of Quality of Life (MANSA). International Journal of Social Psychiatry 45, 7-12. (Pubitemid 29158596)
80. Ram R, Bromet EJ, Eaton WW, Pato C, Schwartz JE (1992). The natural course of schizophrenia: a review of first-admission studies. Schizophrenia Bulletin 18, 185-207.
81. Raven J, Raven JC, Court JH (2003). Manual for Raven's Progressive Matrices and Vocabulary Scales. Section 1: General Overview. Harcourt Assessment: San Antonio, TX.
82. Rietkerk T, Boks MP, Sommer IE, Liddle PF, Ophoff RA, Kahn RS (2008). The genetics of symptom dimensions of schizophrenia: review and meta-analysis. Schizophrenia Research 102, 197-205.
83. Ruggeri M, Lasalvia A, Dall'Agnola R, Wijngaarden van B, Knudsen HC, Leese M, Gaite L, Tansella M, the EPSILON Study Group (2000). Development, internal consistency and reliability of the Verona Service Satisfaction Scale-European Version. EPSILON Study 7. British Journal of Psychiatry 177 (Suppl. 39), 41-48.
84. Ruggeri M, Lasalvia A, Tansella M, Bonetto C, Abate M, Thornicroft G, Allevi L, Ognibene P (2004). Heterogeneity of outcomes in schizophrenia: 3-year follow-up of treated prevalent cases. British Journal of Psychiatry 184, 48-57. (Pubitemid 38085214)
85. Ruggeri M, Salvi G, Bonetto C, Lasalvia A, Allevi L, Parabiaghi A, Bertani M, Tansella M (2007). Outcome of patients dropping out from community-based mental health care: a 6-year multiwave follow-up study. Acta Psychiatrica Scandinavica 116 (Suppl. 437), 42-52. (Pubitemid 350029200)
86. Salvatore P, Baldessarini RJ, Tohen M, Khalsa HM, Sanchez-Toledo JP, Zarate Jr CA, Vieta E, Maggini C (2009). McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients. Journal of Clinical Psychiatry 70, 458-466.
87. Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV (2008). No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. American Journal of Psychiatry 165, 497-506. (Pubitemid 351694293)
88. Shenton ME, Dickey CC, Frumin M, McCarley RW (2001). A review of MRI findings in schizophrenia. Schizophrenia Research 49, 1-52. (Pubitemid 32451739)
89. Shi Y, Li Z, Xu Q, Wang T, Li T, Shen J, Zhang F, Chen J, Zhou G, Ji W, Li B, Xu Y, Liu D, Wang P, Yang P, Liu B, Sun W, Wan C, Qin S, He G, Steinberg S, Cichon S, Werge T, Sigurdsson E, Tosato S, Palotie A, Nöthen MM, Rietschel M, Ophoff RA, Collier DA, Rujescu D, Clair DS, Stefansson H, Stefansson K, Ji J, Wang Q, Li W, Zheng L, Zhang H, Feng G, He L (2011). Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genet ics 43, 1224-1227.
90. Simpson GN, Angus JWS (1970). A rating scale for extrapyramidal side effects. Acta Psychiatrica Scandinavica 212 (Suppl. 44), 11-19.
91. Steen RG, Mull C, McClure R, Hamer RM, Lieberman JA (2006). Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. British Journal of Psychiatry 188, 510-518. (Pubitemid 43844097)
92. Sullivan PF (2008). The dice are rolling for schizophrenia genetics. Psychological Medicine 38, 1693-1696.
93. Tansella M, Balestrieri M, Meneghelli G, Micciolo R (1991). Trends in the provision of psychiatric care 1979-1988. In From Community-Based Psychiatry: Long Term Patterns of Care in South-Verona (ed. M Tansella), pp. 5-16. Psychological Medicine, Monograph Supplement 19. Cambridge University Press: Cambridge
94. Tansella M, Amaddeo F, Burti L, Lasalvia A, Ruggeri M (2006). Evaluating a community-based mental health service focusing on severe mental illness. The Verona experience. Acta Psychiatrica Scandinavica 113 (Suppl. 429), 90-94. (Pubitemid 43340895)
95. Tello JE, Mazzi M, Tansella M, Bonizzato P, Jones J, Amaddeo F (2005). Does socioeconomic status affect the use of community-based psychiatric services? A South Verona case register study. Acta Psychiatrica Scandinavica 112, 215-223. (Pubitemid 41176558)
96. Tosato S, Lasalvia A (2009). The contribution of epidemiology to defining the most appropriate approach to genetic research on schizophrenia. Epidemiologia e Psichiatria Sociale 8, 81-90.
97. Tosato S, Ruggeri M, Bonetto C, Bertani M, Marrella G, Lasalvia A, Cristofalo D, Aprili G, Tansella M, Dazzan P, Diforti M, Murray RM, Collier DA (2007). Association study of dysbindin gene with clinical and outcome measures in a representative cohort of Italian schizophrenic patients. American Journal of Medical Genetic Part B Neuropsychiatric Genetic 144B, 647-659. (Pubitemid 47077150)
98. van Os J, Kapur S (2009). Schizophrenia. Lancet 374, 635-645.
99. van Wijngaarden B, Schene A, Koeter M, Vázquez-Barquero JL, Knudsen HC, Lasalvia A, McCrone P, the EPSILON Study Group (2000). Caregiving in schizophrenia: development, internal consistency and reliability of the Involvement Evaluation Questionnaire-European version (IEQ). British Journal of Psychiatry 177 (Suppl. 39), 21-27.
100. Weinberger DR (1995). From neuropathology to neurodevelopment. Lancet 34, 6552-6557.
101. World Health Organization (1988). Disability Assessment Schedule-II (DAS). World Health Organization: Geneva.
102. World Health Organization (1992a). Schedules for Clinical Assessment in Neuropsychiatry (SCAN), version 1.0. World Health Organization: Geneva.
103. World Health Organization (1992b). Life Chart Schedule (LCS). World Health Organization: Geneva.
104. Wunderink L, Sytema S, Nienhuis FJ, Wiersma D (2009). Clinical recovery in first-episode psychosis. Schizophrenia Bulletin 35, 362-369.