Huwe1: A possible role in PD

Medical Hypotheses

Volumn 79, Issue 3, 2012, Pages 419-

  Salama, Mohamed M ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

HECT DOMAIN E3 UBIQUITIN LIGASE; MYC PROTEIN; NEUROGENIN 1; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL PROLIFERATION; DOPAMINERGIC NERVE CELL; EMBRYONIC STEM CELL; GENE TARGETING; HUMAN; LETTER; NERVOUS SYSTEM DEVELOPMENT; PARKINSON DISEASE; PROTEIN DEGRADATION; PROTEIN FUNCTION; WILD TYPE;

HUMANS; PARKINSON DISEASE; UBIQUITIN-PROTEIN LIGASES;

EID: 84864578591     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.05.017     Document Type: Letter

References (7)

1. Obeso J.A., Rodriguez-Oroz M.C., Goetz C.G., Marin C., Kordower J.H., Rodriguez M., et al. Missing pieces in the Parkinson's disease puzzle. Nat Med 2010, 16:653-661.
2. Wey A., Knoepfler P. C-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain. Oncotarget 2010, 1(2):120-130.
3. D'Arca D., Zhao X., Xu W., et al. Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. PNAS 2010, 107(13):5875-5880.
4. Yang Y., Do H., Tian X., et al. E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation. PNAS 2010, 107(30):13444-13449.
5. Rotin D., Kumar S. Physiological functions of the HECT family of ubiquitin ligases. Nat Rev 2009, 10:398-409.
6. Zhao X., D'Arca D., Lim W., et al. The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell 2010, 17(2):210-221.
7. Stegmuller J., Bonni A. Destroy to create: E3 ubiquitin ligases in neurogenesis. F1000 Biol Rep 2010, 2:38-41.