Destroy to create: E3 ubiquitin ligases in neurogenesis

F1000 Biology Reports

Volumn 2, Issue 1, 2010, Pages

  Stegmüller, Judith ^a   Bonni, Azad ^b  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UBIQUITIN PROTEIN LIGASE E3;

APOPTOSIS; CELLULAR DISTRIBUTION; DENDRITE; EMBRYONIC STEM CELL; MORPHOGENESIS; NERVE FIBER; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PROTEIN DEGRADATION; REVIEW; SYNAPSE;

EID: 77955078750     PISSN: 17404118     EISSN: 1757594X     Source Type: Journal    
DOI: 10.3410/B2-38     Document Type: Review

References (39)

1. Hershko A, Ciechanover A: The ubiquitin system. Annu Rev Biochem 1998, 67:425-79.
2. Deshaies RJ, Joazeiro CA: RING domain E3 ubiquitin ligases. Annu Rev Biochem 2009, 78:399-434.
3. Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T: Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J 2006, 25:1126-36.
4. Amati B: Myc degradation: dancing with ubiquitin ligases. Proc Natl Acad Sci U S A 2004, 101:8843-4.
5. Rotin D, Kumar S: Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 2009, 10:398-409.
6. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ: TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001, 412:346-51.
7. Sun L, Chen ZJ: The novel functions of ubiquitination in signaling. Curr Opin Cell Biol 2004, 16:119-26.
8. Yi JJ, Ehlers MD: Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol Rev 2007, 59:14-39. (Pubitemid 46333994)
9. Stegmuller J, Bonni A: Moving past proliferation: new roles for Cdh1-APC in postmitotic neurons. Trends Neurosci 2005, 28:596-601. (Pubitemid 41476690)
10. Yang Y, Kim AH, Bonni A: The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol 2010, 20:92-9.
11. Gotz M, Huttner WB: The cell biology of neurogenesis. Nat Rev Mol Cell Biol 2005, 6:777-88.
12. Ballas N, Mandel G: The many faces of REST oversee epigenetic programming of neuronal genes. Curr Opin Neurobiol 2005, 15:500-6. (Pubitemid 41394393)
13. Ooi L, Wood IC: Chromatin crosstalk in development and disease: lessons from REST. Nat Rev Genet 2007, 8:544-54. (Pubitemid 46955208)
14. Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJ: SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 2008, 452:370-4.
15. Ang XL, Harper JW: Interwoven ubiquitination oscillators and control of cell cycle transitions. Sci STKE 2004, 2004:pe31.
16. Singh AM, Dalton S: The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell 2009, 5:141-9.
17. Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB: Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer 2004, 4:562-8.
18. Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL, Brodeur GM: Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc Natl Acad Sci U S A 1991, 88:139-43. (Pubitemid 21914443)
19. Gross-Mesilaty S, Reinstein E, Bercovich B, Tobias KE, Schwartz AL, Kahana C, Ciechanover A: Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc Natl Acad Sci U S A 1998, 95:8058-63. (Pubitemid 28326065)
20. Zhao X, Heng JI, Guardavaccaro D, Jiang R, Pagano M, Guillemot F, Iavarone A, Lasorella A: The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol 2008, 10: 643-53. (Pubitemid 351772930)
21. Zhao X, D'Arca D, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, Lasorella A: The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell 2009, 17:210-21.
22. Zhong W, Chia W: Neurogenesis and asymmetric cell division. Curr Opin Neurobiol 2008, 18:4-11.
23. Betschinger J, Mechtler K, Knoblich JA: Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 2006, 124:1241-53.
24. Schwamborn JC, Berezikov E, Knoblich JA: The TRIM-NHL protein TRIM32 activates microRNAs and prevents selfrenewal in mouse neural progenitors. Cell 2009, 136:913-25.
25. Meroni G, Diez-Roux G: TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases. Bioessays 2005, 27:1147-57.
26. Neumuller RA, Betschinger J, Fischer A, Bushati N, Poernbacher I, Mechtler K, Cohen SM, Knoblich JA: Mei-P26 regulates micro- RNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature 2008, 454:241-5. (Pubitemid 351969890)
27. Tuoc TC, Stoykova A: Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitinproteosome system. Genes Dev 2008, 22:1972-86.
28. Kim AH, Bonni A: Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci 2007, 34:281-7.
29. Konishi Y, Stegmuller J, Matsuda T, Bonni S, Bonni A: Cdh1-APC controls axonal growth and patterning in the mammalian brain. Science 2004, 303:1026-30.
30. Stegmuller J, Konishi Y, Huynh MA, Yuan Z, Dibacco S, Bonni A: Cell-intrinsic regulation of axonal morphogenesis by the Cdh1-APC target SnoN. Neuron 2006, 50:389-400.
31. Lasorella A, Stegmuller J, Guardavaccaro D, Liu G, Carro MS, Rothschild G, de la Torre-Ubieta L, Pagano M, Bonni A, Iavarone A: Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature 2006, 442:471-4.
32. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A: A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell 2009, 136:322-36.
33. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A: A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science 2009, 326:575-8.
34. van Roessel P, Elliott DA, Robinson IM, Prokop A, Brand AH: Independent regulation of synaptic size and activity by the anaphase-promoting complex. Cell 2004, 119:707-18.
35. Juo P, Kaplan JM: The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans. Curr Biol 2004, 14:2057-62. (Pubitemid 39547962)
36. Herrero-Mendez A, Almeida A, Fernandez E, Maestre C, Moncada S, Bolanos JP: The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol 2009, 11:747-52.
37. Li M, Shin YH, Hou L, Huang X, Wei Z, Klann E, Zhang P: The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory. Nat Cell Biol 2008, 10:1083-9.
38. Garcia-Higuera I, Manchado E, Dubus P, Canamero M, Mendez J, Moreno S, Malumbres M: Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 2008, 10:802-11.
39. Vescovi AL, Galli R, Reynolds BA: Brain tumour stem cells. Nat Rev Cancer 2006, 6:425-36.