Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Edqvist, Per Henrik D ^a   Niklasson, Mia ^a   Vidal Sanz, Manuel ^b   Hallböök, Finn ^a   Forsberg Nilsson, Karin ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF MURCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; INTRAOCULAR PRESSURE; MOUSE; NEURAL STEM CELL; NONHUMAN; PHOTORECEPTOR; PROTEIN EXPRESSION; RETINA BLOOD VESSEL; RETINA CAPILLARY; RETINA DEVELOPMENT; RETINA MALFORMATION; RETINA STEM CELL; STEM CELL;

ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; CAPILLARIES; CELL DEATH; CELL LINEAGE; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION; HUMANS; INTRAOCULAR PRESSURE; MICE; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; NEUROGLIA; PHOTORECEPTOR CELLS, VERTEBRATE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-SIS; PYRIMIDINES; RETINA; RETINAL VESSELS; STEM CELLS; TIME FACTORS; TRANSGENES;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 84864569776     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042488     Document Type: Article

References (41)

1. Saint-Geniez M, D'Amore PA, (2004) Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol 48: 1045-1058.
2. Ito M, Yoshioka M, (1999) Regression of the hyaloid vessels and pupillary membrane of the mouse. Anat Embryol (Berl) 200: 403-411.
3. Chu Y, Hughes S, Chan-Ling T, (2001) Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma. FASEB J 15: 2013-2015.
4. Fruttiger M, Calver A, Krüger W, Mudhar H, Michalovich D, et al. (1996) PDGF mediates a neuron-astrocyte interaction in the developing retina. Neuron 17: 1117-1131.
5. Fruttiger M, (2002) Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis. Invest Ophthalmol Vis Sci 43: 522-527.
6. Goldberg MF, (1997) Persistent fetal vasculature (PFV): an integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV). LIV Edward Jackson Memorial Lecture. Am J Ophthalmol 124: 587-626.
7. Zhang J, Fuhrmann S, Vetter ML, (2008) A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development. Invest Ophthalmol Vis Sci 49: 5561-5567.
8. Lang RA, Bishop JM, (1993) Macrophages are required for cell death and tissue remodeling in the developing mouse eye. Cell 74: 453-462.
9. Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, et al. (2001) Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet 2: 18.
10. Thornton JD, Swanson DJ, Mary MN, Pei D, Martin AC, et al. (2007) Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor. Invest Ophthalmol Vis Sci 48: 491-499.
11. Reichel MB, Ali RR, D'Esposito F, Clarke AR, Luthert PJ, et al. (1998) High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice. Cell Death Differ 5: 156-162.
12. Hackett SF, Wiegand S, Yancopoulos G, Campochiaro PA, (2002) Angiopoietin-2 plays an important role in retinal angiogenesis. J Cell Physiol 192: 182-187.
13. Lei H, Rheaume MA, Kazlauskas A, (2010) Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res 90: 376-381.
14. Fruttiger M, Calver AR, Richardson WD, (2000) Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not from axons. Curr Biol 10: 1283-1286.
15. Reneker LW, Overbeek PA, (1996) Lens-specific expression of PDGF-A in transgenic mice results in retinal astrocytic hamartomas. Invest Ophthalmol Vis Sci 37: 2455-2466.
16. Mudhar HS, Pollock RA, Wang C, Stiles CD, Richardson WD, (1993) PDGF and its receptors in the developing rodent retina and optic nerve. Development 118: 539-552.
17. Lindahl P, Johansson BR, Leveen P, Betsholtz C, (1997) Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277: 242-245.
18. Vinores SA, Seo MS, Derevjanik NL, Campochiaro PA, (2003) Photoreceptor-specific overexpression of platelet-derived growth factor induces proliferation of endothelial cells, pericytes, and glial cells and aberrant vascular development: an ultrastructural and immunocytochemical study. Brain Res Dev Brain Res 140: 169-183.
19. Forsberg-Nilsson K, Erlandsson A, Zhang X-Q, Ueda H, Svensson K, et al. (2003) Oligodendrocyte precursor hypercellularity and abnormal retina development in mice overexpressing PDGF-B in myelinating tracts. Glia 41: 276-289.
20. Silva RL, Thornton JD, Martin AC, Rehg JE, Bertwistle D, et al. (2005) Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye. EMBO J 24: 2803-2814.
21. Johansson CB, Lothian C, Molin M, Okano H, Lendahl U, (2002) Nestin enhancer requirements for expression in normal and injured adult CNS. J Neurosci Res 69: 784-794.
22. Niklasson M, Bergstrom T, Zhang XQ, Gustafsdottir SM, Sjogren M, et al. (2010) Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells. Exp Cell Res 316: 2779-2789.
23. Salic A, Mitchison TJ, (2008) A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A 105: 2415-2420.
24. Dick O, tom Dieck S, Altrock WD, Ammermuller J, Weiler R, et al. (2003) The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Neuron 37: 775-786.
25. Xue LP, Lu J, Cao Q, Hu S, Ding P, et al. (2006) Müller glial cells express nestin coupled with glial fibrillary acidic protein in experimentally induced glaucoma in the rat retina. Neuroscience pp. 723-732.
26. Fruttiger M, (2007) Development of the retinal vasculature. Angiogenesis 10: 77-88.
27. Homsi J, Daud AI, (2007) Spectrum of activity and mechanism of action of VEGF/PDGF inhibitors. Cancer Control 14: 285-294.
28. Alexandrakis G, Scott IU, Flynn HW Jr, Murray TG, Feuer WJ, (2000) Visual acuity outcomes with and without surgery in patients with persistent fetal vasculature. Ophthalmology 107: 1068-1072.
29. Andrae J, Gallini R, Betsholtz C, (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22: 1276-1312.
30. Lindblom P, Gerhardt H, Liebner S, Abramsson A, Enge M, et al. (2003) Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev 17: 1835-1840.
31. Seo MS, Okamoto N, Vinores MA, Vinores SA, Hackett SF, et al. (2000) Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment. Am J Pathol 157: 995-1005.
32. Mori K, Gehlbach P, Ando A, Dyer G, Lipinsky E, et al. (2002) Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathy. Invest Ophthalmol Vis Sci 43: 2001-2006.
33. Pequignot MO, Provost AC, Salle S, Taupin P, Sainton KM, et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn 228: 231-238.
34. Young RW, (1984) Cell death during differentiation of the retina in the mouse. J Comp Neurol 229: 362-373.
35. Peichl L, Sandmann D, Boycott B (1998) Comparative anatomy and function of mammalian horizontal cells. In: Development and Organization of the Retina From Molecules to Function. Finlay LMCaBL, editor. New York: Plenum Press. 147-172.
36. Guidry C, Bradley KM, King JL, (2003) Tractional force generation by human muller cells: growth factor responsiveness and integrin receptor involvement. Invest Ophthalmol Vis Sci 44: 1355-1363.
37. Watanabe T, Raff MC, (1988) Retinal astrocytes are immigrants from the optic nerve. Nature 332: 834-837.
38. Enge M, Bjarnegard M, Gerhardt H, Gustafsson E, Kalen M, et al. (2002) Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO J 21: 4307-4316.
39. Savinova OV, Sugiyama F, Martin JE, Tomarev SI, Paigen BJ, et al. (2001) Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet 2: 12.
40. Lindsey JD, Weinreb RN, (2005) Elevated intraocular pressure and transgenic applications in the mouse. J Glaucoma 14: 318-320.
41. Chan-Ling T, Chu Y, Baxter L, Weible Ii M, Hughes S, (2009) In vivo characterization of astrocyte precursor cells (APCs) and astrocytes in developing rat retinae: differentiation, proliferation, and apoptosis. Glia 57: 39-53.