Classification of premalignant and malignant lesions developing in the rat mammary gland after injection of sexually immature rats with 1-methyl-1-nitrosourea

Journal of Mammary Gland Biology and Neoplasia

Volumn 5, Issue 2, 2000, Pages 201-210

  Thompson, Henry J ^a   Singh, Meenakshi ^a   McGinley, John ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

1 Methyl 1 nitrosourea; Animal model; Malignant lesions; Mammary carcinogenesis; Premalignant lesions; Rat

Indexed keywords

CYCLIN D1; METHYLNITROSOUREA; OVARY PEPTIDE HORMONE; PROTEIN P27;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; BREAST CANCER; BREAST CARCINOGENESIS; BREAST HYPERPLASIA; CANCER CLASSIFICATION; CANCER GROWTH; CARCINOMA IN SITU; CELL PROLIFERATION; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HORMONE DEPENDENCE; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; NONHUMAN; PROTEIN EXPRESSION; RAT;

ADENOCARCINOMA; ANIMALS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEMALE; GENES, RAS; HYPERPLASIA; LYMPHATIC METASTASIS; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; MUTATION; NEOPLASM METASTASIS; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034520277     PISSN: 10833021     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026495322596     Document Type: Article

References (16)

1. Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methyl-1-nitrosourea
2. Ovarian hormone dependence of pre-malignant and malignant mammary gland lesions induced in pre-pubertal rats by 1-methyl-1-nitrosourea
3. Temporal sequence of mammary intraductal proliferations, ductal carcinomas in situ and adenocarcinomas induced by 1-methyl-1-nitrosourea in rats
4. Preparing mammary gland whole mounts from mice
5. Pathology of tumors in laboratory animals. Tumors of the rat. Tumors of the mammary gland
6. Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea
7. Effect of carcinogen dose and age at administration on induction of mammary carcinogenesis by 1-methyl-1-nitrosourea
8. Comparative study of human and rat mammary tumorigenesis
9. Effect of energy restriction on the expression of cyclin D1 and p27 during premalignant and malignant stages of chemically induced mammary carcinogenesis
10. Deregulated expression of p27(Kip1) in human breast cancers
11. Immunohistochemical detection and gene amplification of cyclin D1 in mammary infiltrating ductal carcinoma
12. Quantitating the frequency of initiation and cH-ras mutation in in situ N-methyl-N-nitrosourea-exposed rat mammary gland
13. Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels
14. A range of 30 to 70% of carcinomas harbor a mutant allele depending on carcinogen dose. Microsatellite instability in an animal model of mammary carcinogenesis