Amelioration of cisplatin-induced rat renal lesions by a cyclooxygenase (COX)-2 selective inhibitor

Experimental and Toxicologic Pathology

Volumn 64, Issue 6, 2012, Pages 625-631

  Yamamato, Emi ^a   Izawa, Takeshi ^a   Sawamoto, Osamu ^b   Juniantito, Vetnizah ^a   Kuwamura, Mitsuru ^a   Yamate, Jyoji ^a  

^a Osaka Prefecture University   (Japan)

^b Safety Evaluation   (Japan)

Author keywords

Cisplatin induced renal failure; COX 2; Macrophage; PGE2; TGF 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BROXURIDINE; CISPLATIN; CREATININE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; TRANSFORMING GROWTH FACTOR BETA1; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL PROTECTION; CELL REGENERATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; KIDNEY EPITHELIUM; KIDNEY FAILURE; KIDNEY FIBROSIS; MACROPHAGE; MALE; MYOFIBROBLAST; NONHUMAN; RAT; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; CYCLOOXYGENASE 2 INHIBITORS; IMMUNOHISTOCHEMISTRY; KIDNEY; MALE; NITROBENZENES; RATS; RATS, INBRED F344; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONAMIDES;

RATTUS;

EID: 84864527950     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.12.005     Document Type: Article

References (28)

1. Blume C., Heise G., Mühlfeld A., Bach D., Schrör K., Gerhardz C.D., et al. Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive Heymann nephritis in the rat. Kidney Int 1999, 56:1770-1778.
2. Brzozowski T., Konturek P.C., Konturek S.J., Drozdowicz D., Pajdo R., Pawlik M., et al. Expression of cyclooxygenase (COX)-1 and COX-2 in adaptive cytoprotection induced by mild stress. J Physiol Paris 2000, 94:83-91.
3. Fukusawa H., Yamamoto T., Suzuki H., Togawa A., Ohashi N., Fujigaki Y., et al. Treatment with anti-TGF-β antibody ameliolates chronic progressive nephritis by inhibiting Smad/TGF-β signaling. Kidney Int 2004, 65:63-74.
4. Gierse J.K., McDonald J.J., Hauser S.D., Rangwala S.H., Koboldt C.M., Seibert K. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem 1996, 271:15810-15814.
5. Harding P. Do COX-2 inhibitors reduce renal fibrosis?. J Hypertens 2004, 22:43-45.
6. Harris R.C., Breyer M.D. Physiological regulation of cyclooxygenase-2 in the kidney. Am J Physiol Renal Physiol 2001, 281:F1-F11.
7. Kitahara M., Eitner F., Ostendorf T., Kunter U., Janssen U., Westenfeld R., et al. Selective cyclooxygenase-2 inhibition impairs glomerular capillary healing in experimental glomerulonephritis. J Am Soc Nephrol 2002, 13:1261-1270.
8. Klahr S., Morrissey J. Obstructive nephropathy and renal fibrosis: the role of bone morphogenic protein-7 and hepatocyte growth factor. Kidney Int Suppl 2003, 87:S105-S112.
9. 2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation. Am J Respir Cell Mol Biol 2003, 29:537-544.
10. Matsumoto K., Watanabe Y., Ohya M.A., Yokoyama S. Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity model. Biol Pharm Bull 2006, 29:2532-2535.
11. Megyesi J., Andrade L., Vieira J.M., Safirstein R.L., Price P.M. Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure. Am J Physiol Renal Physiol 2002, 283:F810-F816.
12. Miyaji T., Kato A., Yasuda H., Fujigaki Y., Hishida A. Role of the increase in p21 in cisplatin-induced acute renal failure in rats. J Am Soc Nephrol 2001, 12:900-908.
13. Muskhelishvili L., Latendresse J.R., Kodell R.L., Henderson E.B. Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ hybridization for histone mRNA. J Histochem Cytochem 2003, 51:1681-1688.
14. Ng Y.Y., Huang T.P., Yang W.C., Chen Z.P., Yang A.H., Mu W., et al. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 1998, 54:864-876.
15. Oshima H., Oshima M., Inaba K., Taketo M.M. Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. EMBO J 2004, 23:1669-1678.
16. Ouellet M., Percival M.D. Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J 1995, 306:247-251.
17. Price P.M., Yu F., Kaldis P., Aleem E., Nowak G., Safirstein R.L., et al. Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am Soc Nephrol 2006, 17:2434-2442.
18. Sanchez P.L., Salgado L.M., Ferreri N.R., Escalante B. Effects of cyclooxygenase-2 inhibition on renal function after ablation. Hypertension 1999, 34:848-853.
19. Stacey D.W. Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells. Curr Opin Cell Biol 2003, 15:158-163.
20. Stubbe J., Jensen B.L., Bachmann S., Morsing P., Sktt O. Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats. Am J Physiol Regul Integr Comp Physiol 2003, 284:R1179-R1189.
21. Subbaramaiah K., Dannenberg A.J. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol Sci 2003, 24:96-102.
22. Suzuki M., Adachi K., Ogawa Y., Karasawa Y., Katsuyama K., Sugimoto T., et al. The combination of fixation and embedding in paraffin by the AMeX method in useful for immunohistochemical and enzyme histochemical studies of the lung. J Toxicol Pathol 2000, 13:109-113.
23. Tsujino K., Yamate J., Tsukamoto Y., Kumagai D., Kannan Y., Jippo T., et al. Establishment and characterization of cell lines derived from a transplantable rat malignant meningioma: morphological heterogeneity and production of nerve growth factor. Acta Neuropathol 1997, 93:461-470.
24. Yamamoto E., Izawa T., Juniantito V., Kuwamura M., Sugiura K., Takeuchi T., et al. Involvement of endogenous prostaglandin E2 in tubular epithelial regeneration through inhibition of apoptosis and epithelial-mesenchymal transition in cisplatin-induced rat renal lesions. Histol Histopathol 2010, 25:995-1007.
25. Yamate J., Sato K., Machida Y., Ide M., Sato S., Nakatsuji S., et al. Cisplatin-induced rat renal interstitial fibrosis; a possible pathogenesis based on the data. J Toxicol Pathol 2000, 13:237-247.
26. Yamate J., Machida Y., Ide M., Kuwamura M., Sawamoto O., LaMarre J. Effects of lipopolysaccharide on the appearance of macrophage populations and fibrogenesis in cisplatin-induced rat renal injury. Exp Toxicol Pathol 2004, 56:13-24.
27. Yamate J., Tatsumi M., Nakatsuji S., Kuwamura M., Kotani T., Sakuma S. Immunohistochemical observations on the kinetics of macrophages and myofibroblasts in rat renal interstitial fibrosis induced by cis-diamminedichloroplatinum. J Comp Pathol 1995, 112:27-39.
28. Zeisberg M., Kalluri R. The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 2004, 82:175-181.