NAD(P)H oxidase p22phox polymorphism and cardiovascular function in amateur runners

Acta Physiologica

Volumn 206, Issue 1, 2012, Pages 20-28

  Gallina, S ^a   Di Francescomarino, S ^a   Di Mauro, M ^a   Izzicupo, P ^a   D'Angelo, E ^a   D'Amico, M A ^a   Pennelli, A ^a   Amicarelli, F ^b   Di Baldassarre, A ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Arterial compliance; Physical exercise; ROS.

Indexed keywords

PROTEIN P22; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADULT; ARTERIAL STIFFNESS; ARTICLE; AUGMENTATION INDEX; CARDIOVASCULAR FUNCTION; CLINICAL ASSESSMENT; DIASTOLIC BLOOD PRESSURE; DOPPLER ECHOCARDIOGRAPHY; EXCITATION CONTRACTION COUPLING; HEART CONTRACTION; HEART LEFT VENTRICLE FILLING; HEART SIZE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PULSE WAVE; RUNNING; TONOMETER; TRICUSPID VALVE;

ADULT; ALLELES; BLOOD PRESSURE; ECHOCARDIOGRAPHY, DOPPLER; GENOTYPE; HEART RATE; HUMANS; MALE; NADPH OXIDASE; POLYMORPHISM, GENETIC; RUNNING;

EID: 84864527827     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2012.02456.x     Document Type: Article

References (47)

1. Akhtar, K., Broekelmann, T.J., Miao, M., Keeley, F.W., Starcher, B.C., Pierce, R.A., Mecham, R.P. & Adair-Kirk, T.L. 2010. Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro J Biol Chem 285, 37396-37404.
2. Akki, A., Zhang, M., Murdoch, C., Brewer, A. & Shah, A.M. 2009. NADPH oxidase signaling and cardiac myocyte function. J Mol Cell Cardiol 47, 15-22.
3. Antonini-Canterin, F., Carerj, S., Di Bello, V., Di Salvo, G., La Carrubb, S., Vriz, O., Pavan, D., Balbarini, A., Nicolosi, G.L. & Research Group of the Italian Society of Cardiovascular Echography (SIEC) 2009. Arterial stiffness and ventricular stiffness: a couple of diseases or a coupling disease? A review from the cardiologist's point of view. Eur J Echocardiogr 10, 36-43.
4. Delles, C., Zimmerli, L.U., McGrane, D.J., Koh-Tan, C.H., Pathi, V.L., McKay, A.J., Steedman, T., Dargie, H.J., Hamilton, C.A. & Dominiczak, A.F. 2008. Vascular stiffness is related to superoxide generation in the vessel wall. J Hypertens 26, 946-955.
5. Devereux, R.B., Alonso, D.R., Lutas, E.M., Gottlieb, G.J., Campo, E., Sachs, I. & Reichek, N. 1986. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 57, 450-458.
6. Di Francescomarino, S., Sciartilli, A., Di Valerio, V., Di Baldassarre, A. & Gallina, S. 2009. The effect of physical exercise on endothelial function. Sports Med 39, 797-812.
7. Di Mauro, M., Izzicupo, P., Santarelli, F., Falone, S., Pennelli, A., Amicarelli, F., Calafiore, A.M., Di Baldassarre, A. & Gallina, S. 2010. ACE and AGTR1 polymorphisms and left ventricular hypertrophy in endurance athletes. Med Sci Sports Exerc 42, 915-921.
8. Di Paolo, F.M. & Pelliccia, A. 2007. The "Athlete's Heart": relation to gender and race. Cardiol Clin 25, 383-389.
9. Dikalova, A.E., Góngora, M.C., Harrison, D.G., Lambeth, J.D., Dikalov, S. & Griendling, K.K. 2010. Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling. Am J Physiol Heart Circ Physiol 299, H673-H679.
10. Domanski, M.J., Mitchell, G.F., Norman, J.E., Exner, D.V., Pitt, B. & Pfeffer, M.A. 1999. Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction. J Am Coll Cardiol 33, 951-958.
11. Douglas, P.S., Reichek, N., Plappert, T., Muhammad, A. & St John Sutton, M.G. 1987. Comparison of echocardiographic methods for assessment of left ventricular shortening and wall stress. J Am Coll Cardiol 9, 945-951.
12. Dworakowski, R., Anilkumar, N., Zhang, M. & Shah, A.M. 2006. Redox signalling involving NADPH oxidase-derived reactive oxygen species. Biochem Soc Trans 34, 960-964.
13. Falone, S., Mirabilio, A., Passerini, A., Izzicupo, P., Cacchio, M., Gallina, S., Di Baldassarre, A. & Amicarelli, F. 2009. Aerobic performance and antioxidant protection in runners. Int J Sports Med 30, 782-788.
14. phox gene polymorphisms, and hypertension. Med Sci Sports Exerc 41, 1421-1428.
15. Florescu, M., Stoicescu, C., Magda, S., Petcu, I., Radu, M., Palombo, C., Cinteza, M., Lichiardopol, R. & Vinereanu, D. 2010. "Supranormal" cardiac function in athletes related to better arterial and endothelial function. Echocardiography 27, 659-667.
16. Fortuno, A., San Jose, G., Moreno, M.U., Diez, J. & Zalba, G. 2005. Oxidative stress and vascular remodelling. Exp Physiol 90, 457-462.
17. Griendling, K.K., Minieri, C.A., Ollerenshaw, J.D. & Alexander, R.W. 1994. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74, 1141-1148.
18. phox gene on vascular superoxide production in atherosclerosis. Circulation 102, 1744-1747.
19. phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes. Diabetes Care 26, 458-463.
20. Ikonomidis, I., Lekakis, J., Stamatelopoulos, K., Markomihelakis, N., Kaklamanis, P.G. & Mavrikakis, M. 2004. Aortic elastic properties and left ventricular diastolic function in patients with Adamantiades- Behcet's disease. J Am Coll Cardiol 43, 075-081.
21. phox gene in patients with coronary artery disease. Circulation 97, 135-137.
22. phox subunit. Int J Immunopathol Pharmacol 23, 203-211.
23. Kaul, S., Tei, C., Hopkins, J.M. & Shah, P.M. 1984. Assessment of right ventricular function using two-dimensional echocardiography. Am Heart J 107, 526-531.
24. Kelly, R.P., Millasseau, S.C., Ritter, J.M. & Chowienczyk, P.J. 2001. Vasoactive drugs influence aortic augmentation index independently of pulse-wave velocity in healthy men. Hypertension 37, 1429-1433.
25. Lang, R.M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Roman, M.J., Seward, J., Shanewise, J.S., Solomon, S.D., Spencer, K.T., Sutton, M.S., Stewart, W.J., Chamber Quantification Writing Group, American Society of Echocardiography's Guidelines, Standards Committee & European Association of Echocardiography 2005. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18, 1440-1463.
26. Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H. & European Network for Non-invasive Investigation of Large Arteries 2006. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27, 2588-2605.
27. Li, J.M. & Shah, A.M. 2004. Endothelial cell superoxide generation: regulation and relevance for CV pathophysiology. Am J Physiol Regul Integr Comp Physiol 287, R1014-R1030.
28. Merillon, J.P., Lebras, Y., Chastre, J., Lerallut, J.F., Motte, G., Fontenier, G., Huet, Y., Jaffrin, M.Y. & Gourgon, R. 1983. Forward and backward waves in the arterial system, their relationship to pressure waves form. Eur Heart J 4, 13-20.
29. Mottram, P.M., Haluska, B.A., Leano, R., Carlier, S., Case, C. & Marwick, T.H. 2005. Relation of arterial stiffness to diastolic dysfunction in hypertensive heart disease. Heart 91, 1551-1556.
30. Murdoch, C.E., Zhang, M., Cave, A.C. & Shah, A.M. 2006. NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure. Cardiovasc Res 71, 208-215.
31. Nagueh, S.F., Appleton, C.P., Gillebert, T.C., Marino, P.N., Oh, J.K. & Smiseth, O.A. 2009. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr 10, 165-193.
32. Nediani, C., Borchi, E., Giordano, C., Baruzzo, S., Ponziani, V., Sebastiani, M., Nassi, P., Mugelli, A., d'Amati, G. & Cerbai, E. 2007. NADPH oxidase-dependent redox signaling in human heart failure: relationship between the left and right ventricle. J Mol Cell Cardiol 42, 826-834.
33. Nieman, D. 2010. Exercise Testing and Prescription. A Health-Related Approach, 7th edn, p. 63-65: 121. McGraw Hill, New York.
34. Ommen, S.R., Nishimura, R.A., Appleton, C.P., Miller, F.A., Oh, J.K., Redfield, M.M. & Tajik, A.J. 2000. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation 102, 1788-1794.
35. phox gene variants are associated with systemic oxidative stress biomarker responses to exercise training. J Appl Physiol 99, 1905-1911.
36. Pelliccia, A. & Thompson, P.D. 2006. The genetics of left ventricular remodeling in competitive athletes. J Cardiovasc Med (Hagerstown) 7, 267-270.
37. Salvi, P., Lio, G., Labat, C., Ricci, E., Pannier, B. & Benetos, A. 2004. Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device. J Hypertens 22, 2285-2293.
38. San Jose, G., Fortuno, A., Beloqui, O., Diez, J. & Zalba, G. 2008. NADPH oxidase CYBA polymorphisms, oxidative stress and CV diseases. Clin Sci (Lond) 114, 173-182.
39. Schussheim, A.E., Devereux, R.B., de Simone, G., Borer, J.S., Herrold, E.M. & Laragh, J.H. 1997. Usefulness of subnormal midwall fractional shortening in predicting left ventricular exercise dysfunction in asymptomatic patients with systemic hypertension. Am J Cardiol 79, 1070-1074.
40. Sheriff, D.D. 2010. Role of mechanical factors in governing muscle blood flow. Acta Physiol (Oxf) 199, 385-391.
41. Sirker, A., Zhang, M., Murdoch, C. & Shah, A.M. 2007. Involvement of NADPH oxidases in cardiac remodelling and heart failure. Am J Nephrol 27, 649-660.
42. Soccio, M., Toniato, E., Evangelista, V., Carluccio, M. & De Caterina, R. 2005. Oxidative stress and CV risk: the role of vascular NAD(P)H oxidase and its genetic variants. Eur J Clin Invest 35, 305-314.
43. Takimoto, E. & Kass, D.A. 2007. Role of oxidative stress in cardiac hypertrophy and remodeling. Hypertension 49, 241-248.
44. phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271, 23317-13321.
45. Wilkinson, I.B., Cockcroft, J.R. & Webb, D.J. 1998. Pulse wave analysis and arterial stiffness. J Cardiovasc Pharmacol 32, S33-S37.
46. Wyche, K.E., Wang, S.S., Griendling, K.K., Dikalov, S.I., Austin, H., Rao, S., Fink, B., Harrison, D.G. & Zafari, A.M. 2004. C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils. Hypertension 43, 1246-1251.
47. Zima, A.V. & Blatter, L.A. 2006. Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71, 310-321.