Neurological soft signs in obsessive-compulsive disorder: The effect of co-morbid psychosis and evidence for familiality

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 39, Issue 1, 2012, Pages 200-205

  Peng, Zi wen ^a,b   Xu, Ting ^a   Miao, Guo dong ^c   He, Qing huan ^c   Zhao, Qing ^a   Dazzan, Paola ^d   Chan, Raymond C K ^a  

^a INSTITUTE OF PSYCHOLOGY   (China)

^b SOUTH CHINA NORMAL UNIVERSITY   (China)

^c Guangzhou Psychiatry Hospital   (China)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Co morbidity; Neurological soft signs; Obsessive compulsive disorder; Unaffected siblings

Indexed keywords

CHLORPROMAZINE; CITALOPRAM; CLOMIPRAMINE; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; LITHIUM CARBONATE; LORAZEPAM; OLANZAPINE; PAROXETINE; QUETIAPINE; RISPERIDONE; SERTRALINE; TRIHEXYPHENIDYL; VALPROIC ACID; VENLAFAXINE;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE RESPONSE; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NEUROLOGICAL SOFT SIGN; NEUROPSYCHOLOGICAL TEST; OBSESSIVE COMPULSIVE DISORDER; PSYCHOLOGIC ASSESSMENT; PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM;

ADULT; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHINA; COMORBIDITY; FAMILY; HUMANS; MALE; NERVOUS SYSTEM DISEASES; NEUROLOGIC EXAMINATION; OBSESSIVE-COMPULSIVE DISORDER; PREVALENCE; SCHIZOPHRENIA; SYMPTOM ASSESSMENT;

EID: 84864527405     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.06.015     Document Type: Article

References (28)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 1994, (DSM-IV), APA. 4th edn.
2. Beck A.T., Steer R.A. Internal consistencies of the original and revised Beck Depression Inventory. J Clin Psychol 1984, 40(6):1365-1367.
3. Bersani G., Gherardelli S., Clemente R., Di Giannantonio M., Grilli A., Conti C.M., et al. Neurologic soft signs in schizophrenic patients treated with conventional and atypical antipsychotics. J Clin Psychopharmacol 2005, 25(4):372-375.
4. Boks M.P., Liddle P.F., Russo S., Knegtering R., van den Bosch R.J. Influence of antipsychotic agents on neurological soft signs and dyskinesia in first episode psychosis. Psychiatry Res 2003, 119(1-2):167-170.
5. Bolton D., Gibb W., Lees A., Raven P., Gray J.A., Chen E., et al. Neurological soft signs in obsessive compulsive disorder: standardised assessment and comparison with schizophrenia. Behav Neurol 1998, 11(4):197-204.
6. Chan R.C., Chen E.Y. Neurological abnormalities in Chinese schizophrenic patients. Behav Neurol 2007, 18(3):171-181.
7. Chan R.C., Gottesman I.I. Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star?. Neurosci Biobehav Rev 2008, 32(5):957-971.
8. Chan R.C., Wang Y., Wang L., Chen E.Y., Manschreck T.C., Li Z.J., et al. Neurological soft signs and their relationships to neurocognitive functions: a re-visit with the structural equation modeling design. PLoS One 2009, 4(12):e8469.
9. Chan R.C., McAlonan G.M., Yang B., Lin L., Shum D., Manschreck T.C. Prevalence of neurological soft signs and their neuropsychological correlates in typically developing Chinese children and Chinese children with ADHD. Dev Neuropsychol 2010, 35(6):698-711.
10. Chan R.C., Wang Y., Zhao Q., Yan C., Xu T., Gong Q.Y., et al. Neurological soft signs in individuals with schizotypal personality features. Aust N Z J Psychiatry 2010, 44(9):800-804.
11. Chan R.C., Xu T., Heinrichs R.W., Yu Y., Gong Q.Y. Neurological soft signs in non-psychotic first-degree relatives of patients with schizophrenia: a systematic review and meta-analysis. Neurosci Biobehav Rev 2010, 34(6):889-896.
12. Chan R.C., Xu T., Heinrichs R.W., Yu Y., Wang Y. Neurological soft signs in schizophrenia: a meta-analysis. Schizophr Bull 2010, 36(6):1089-1104.
13. Chen E.Y., Shapleske J., Luque R., McKenna P.J., Hodges J.R., Calloway S.P., et al. The Cambridge Neurological Inventory: a clinical instrument for assessment of soft neurological signs in psychiatric patients. Psychiatry Res 1995, 56(2):183-204.
14. Dazzan P., Lloyd T., Morgan K.D., Zanelli J., Morgan C., Orr K., et al. Neurological abnormalities and cognitive ability in first-episode psychosis. Br J Psychiatry 2008, 193(3):197-202.
15. Fabisch K., Fabisch H., Langs G., Huber H.P., Zapotoczky H.G. Incidence of obsessive-compulsive phenomena in the course of acute schizophrenia and schizoaffective disorder. Eur Psychiatry 2001, 16(6):336-341.
16. Foa E.B., Huppert J.D., Leiberg S., Langner R., Kichic R., Hajcak G., et al. The Obsessive-Compulsive Inventory: development and validation of a short version. Psychol Assess 2002, 14(4):485-496.
17. Gold J.M., Carpenter C., Randolph C., Goldberg T.E., Weinberger D.R. Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Arch Gen Psychiatry 1997, 54(2):159-165.
18. Gong Y.X. Manual of Wechsler Adult Intelligence Scale: Chinese version 1992, Chinese Map Press, Changsha.
19. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., et al. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch Gen Psychiatry 1989, 46(11):1012-1016.
20. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989, 46(11):1006-1011.
21. Mataix-Cols D., Alonso P., Hernandez R., Deckersbach T., Savage C.R., Manuel Menchon J., et al. Relation of neurological soft signs to nonverbal memory performance in obsessive-compulsive disorder. J Clin Exp Neuropsychol 2003, 25(6):842-851.
22. Peng Z.W., Yang W.H., Miao G.D., Jing J., Chan R.C. The Chinese version of the Obsessive-Compulsive Inventory-Revised scale: replication and extension to non-clinical and clinical individuals with OCD symptoms. BMC Psychiatry 2011, 11:129.
23. Poyurovsky M., Faragian S., Pashinian A., Levi A., Viosburd A., Stryjer R., et al. Neurological soft signs in schizophrenia patients with obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 2007, 19(2):145-150.
24. Saxena S., Rauch S.L. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 2000, 23(3):563-586.
25. Sevincok L., Akoglu A., Topaloglu B., Aslantas H. Neurological soft signs in schizophrenic patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 2004, 58(3):274-279.
26. Sevincok L., Akoglu A., Arslantas H. Schizo-obsessive and obsessive-compulsive disorder: comparison of clinical characteristics and neurological soft signs. Psychiatry Res 2006, 145(2-3):241-248.
27. Spielberger D.C. Manual for the State-Trait Anxiety Inventory (STAI) 1983, Mind Garden, PaloAlto CA.
28. Thomas N., Tharyan P. Soft neurological signs in drug-free people with schizophrenia with and without obsessive-compulsive symptoms. J Neuropsychiatry Clin Neurosci 2011, 23(1):68-73.