Neurological soft signs in obsessive compulsive disorder: Standardised assessment and comparison with schizophrenia

Behavioural Neurology

Volumn 11, Issue 4, 1998, Pages 197-204

  Bolton, D ^a   Gibb, W ^b   Lees, A ^c   Raven, P ^d   Gray, J A ^a   Chen, E ^e   Shafran, R ^f  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^c NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^d ROYAL FREE HOSPITAL   (United Kingdom)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

^f UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Neurological soft signs; Obsessive compulsive disorder; Schizophrenia; Specificity

Indexed keywords

NEUROLEPTIC AGENT; PSYCHOTROPIC AGENT;

ADULT; AGED; ARTICLE; CATATONIA; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXTRAPYRAMIDAL SYNDROME; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; OBSESSION; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; REFLEX; SCHIZOPHRENIA; SENSORY DYSFUNCTION; STANDARDIZATION; TARDIVE DYSKINESIA;

EID: 0032230757     PISSN: 09534180     EISSN: None     Source Type: Journal    
DOI: 10.1155/1999/639045     Document Type: Article

References (78)

1. M. Abbruzzese, L. Bellodi, S. Ferri and S. Scarone, Frontal lobe dysfunction in schizophrenia and obsessive compulsive disorder: A neuropsychological study, Brain and Cognition 27 (1995), 202-212.
2. G.E. Alexander, M.R. DeLong and P.L. Strick, Parallel organization of functionally segregated circuits linking basal ganglia and cortex, Annual Review of Neuroscience 9 (1986), 357-381.
3. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 3rd Edition Revised, American Psychiatric Association, Washington, 1987.
4. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, American Psychiatric Association, Washington D.C., 1994.
5. A. Anastasi, Psychological Testing, Macmillan, New York, 1988.
6. R. Bartha, M.B. Murray, P.C. Williamson, D.J. Drost, R.W.J Neufeld, T.J. Carr, G. Canaran, M. Densmore, G. Anderson and A. Razzaque, A short echo-sup-IH spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive compulsive disorder and comparison subjects, American Journal of Psychiatry 155 (1998), 1584-1591.
7. M.L. Berthier, J. Kulisevsky, A. Gironell and J.A. Heras, Obsessive-compulsive disorder associated with brain lesions: clinical phenomenology, cognitive function, and anatomic correlates, Neurology 47 (1996), 353-361.
8. K. Bihari, M.T. Pato, J. L. Hill and D.L. Murphy, Neurological soft signs on obsessive-compulsive disorder, Archives of General Psychiatry 48 (1991), 278.
9. T. Blanes and P. McGuire, Heterogeneity within obsessive-compulsive disorder: Evidence for primary and neurodevelopmental subtypes, in: Neurodevelopmental models of psychopathology, M.S. Keshavan and R. Murray, eds, Cambridge University Press, London, 1997, pp. 206-213.
10. D. Bolton, P. Raven, R. Madronal-Luque and I. Marks, Neurological and neuropsychological signs in Obsessive Compulsive Disorder: interaction with behavioural treatment, Behaviour Research and Therapy (in press).
11. H.C. Breiter, S.L. Rauch, K.K. Kwong, J.R. Baker, R.M. Weisskoff, D.N. Kennedy, A.D. Kendrick, T.L. Davis, A. Jiang, M.S. Cohen, C.E. Stern, J.W. Belliveau, L. Baer, R.L. O'Sullivan, C.R. Savage, M.A. Jenike and B.R. Rosen, Functional magnetic resonance imaging of symptom provocation in obsessive compulsive disorder, Archives of General Psychiatry 53 (1996), 595-606.
12. R.W. Buchanan and D.W. Heinrichs, The neurological evaluation scale (NES): A structured instrument for the assessment of neurological signs in schizophrenia, Psychiatry Research 27 (1989), 335-350.
13. E.Y.H. Chen, J. Shapleske, R. Luque, P.J. McKenna, J.R. Hodges, S.P. Calloway, N.F.S. Hymas, T.R. Dening and G.E. Berrios, The Cambridge Neurological Inventory: A clinical instrument for soft neurological signs and the further neurological examination of psychiatric patients, Psychiatry Research 56 (1995), 183-204.
14. E.Y.H. Chen, L.C.W. Lam, R.Y.L. Chen, D.G.H. Nguyen, C.K.Y. Chan and A.J. Wilkins, Neuropsychological correlates of sustained attention in schizophrenia, Schizophrenia Research 24 (1997), 299-310.
15. J. Cottraux, D. Gérard, L. Cinotti, J. Froment, M. Deiber, D. Le Bars, G. Galy, P. Millet, C. Labbé, F. Lavenne, M. Bouvard and F. Mauguiere, A controlled positron emission tomography study of obsessive and neutral auditory stimulation in obsessive-compulsive disorder with checking rituals, Psychiatry Research 60 (1996), 101-112.
16. J.M. Davis, Dose equivalence of anti-psychotic drugs, Journal of Psychiatric Research 11 (1974), 65-69.
17. M. Denckla, Neurological examination, in: Obsessive-Compulsive Disorder in Children and Adolescents, J.L. Rapoport, ed., American Psychiatric Press Inc., Washington, 1989, pp. 107-115.
18. G.A. Doody, E.C. Johnstone, T.L. Sanderson, D.G.C. Owens and W.J. Muir, 'Pfropfschizophrenie' revisited. Schizophrenia in people with mild learning disability, British Journal of Psychiatry 173 (1998), 145-153.
19. J.L. Eisen, D.A. Beer, M.T. Pato, T.A. Venditto and S.A. Rasmussen, Obsessive-compulsive Disorder in patients with schizophrenia or schizoaffective disorder, American Journal of Psychiatry 154 (1997), 271-273.
20. L.A. Flashman, M. Flaum, S. Gupta and N.C. Andreasen, Soft signs and neuropsychological performance in schizophrenia, American Journal of Psychiatry 153 (1996), 526-532.
21. S. Galderisi, A. Mucci, F. Catapano, A.C. D'Amato and M. Maj, Neuropsychological slowness in obsessive-compulsive patients: Is it confined to tests involving the fronto-subcortical systems?, British Journal of Psychiatry 167 (1995), 394-398.
22. Garver, The etiologic heterogeneity of schizophrenia, Harvard review of Psychiatry 4 (1997), 317-327.
23. D. Geller, J. Biederman, J. Jones, K. Park, S. Schwartz, S. Shapiro and B. Coffey, Is juvenile obsessive-compulsive disorder a developmental subtype of the disorder? A review of the paediatric literature, Journal of the American Academy of Child and adolescent Psychiatry 37 (1998), 420-427.
24. L. Grimshaw, Obsessional disorder and neurological illness, Journal of Neurology, Neurosurgery and Psychiatry 27 (1964), 229-231.
25. S. Gupta, N.C. Andreasen, S. Arndt, M. Flaum, S.K. Schultz, W.C. Hubbard and M. Smith, Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects, American Journal of Psychiatry 152 (1995), 191-196.
26. S. Gupta, R. Rajaprabhakaran, S. Arndt, M. Flaum and N.C. Andreasen, Premorbid adjustment as a predictor of phenomenological and neurobiological indices in schizophrenia, Schizophrenia Research 16 (1995), 189-197.
27. P. Hay, P. Sachdev, S. Cumming, J.S. Smith, T. Lee, P. Kitchener and J. Matheson, Treatment of obsessive compulsive disorder by psychosurgery, Acta Psychiatrica Scandinavica 87 (1993), 197-207.
28. D.W. Heinrichs and R.W. Buchanan, Significance and meaning of neurological signs in schizophrenia, American Journal of Psychiatry 145 (1988), 11-18.
29. R. Hoehn-Saric and C. Benkelfat, Structural and functional brain imaging in obsessive-compulsive disorder, in: Current insights in obsessive compulsive disorder, E. Hollander, J. Zohar, D. Marazziti and B. Olivier, eds, Wiley, Chichester, 1994, pp. 183-211.
30. E. Hollander, E. Schiffman, B. Cohen, M.A. Rivera-Stein, W. Rosen, J.M. Gorman, A.K. Fryer, L. Papp and M.R. Liebowitz, Signs of central nervous system dysfunction in obsessive-compulsive disorder, Archives of General Psychiatry 47 (1990), 27-32.
31. E. Hollander, M.R. Liebowitz and W.G. Rosen, Neuropsychiatric and Neuropsychological Studies in Obsessive-Compulsive Disorder, in: The Psychobiology of Obsessive-Compulsive Disorder, J. Zohar, T. Insel and S. Rasmussen, eds, Springer-Verlag, New York, 1991, pp. 126-145.
32. E. Hollander, C. DeCaria, J. Saoud, D.F. Klein and M.R. Liebowitz, Neurologic soft signs in obsessive-compulsive disorder (letter), Archives of General Psychiatry 48 (1991), 278-279.
33. N. Hymas, A. Lees, D. Bolton, K. Epps and D. Head, The neurology of obsessional slowness, Brain 114 (1991), 2203-2033.
34. B. Ismail, E. Cantor-Graae and T.F. McNeil, Neurological abnormalities in schizophrenic patients and their siblings, American Journal of Psychiatry 155 (1998), 84-89.
35. M.A. Jenike, H.C. Breiter, L. Baer, D.N. Kennedy, C.R. Savage, M.J. Olivares, R.L. O'Sullivan, D.M. Shera, S.L. Rauch, N. Keuthen, B.R. Rosen, V.S. Caviness and P.A. Filipek, Cerebral structural abnormalities in obsessive compulsive disorder, Archives of General Psychiatry 53 (1996), 625-632.
36. M.A. Kennard, Value of equivocal signs in neurologic diagnosis, Neurology 10 (1960), 753-764.
37. S. Khanna, Soft neurological signs in obsessive compulsive disorder, Biological Psychiatry 29 (1991), 442S.
38. D.J. King, A. Wilson, S.G. Cooper and J.L. Waddington, The clinical correlates of neurological soft signs in chronic schizophrenia, British Journal of Psychiatry 155 (1991), 770-775.
39. T. Kolakowska, A.O. Williams, K. Jambor and M. Ardern, Schizophrenia with good and poor outcome. III, Neurological 'soft' signs, cognitive impairment and their clinical significance, British Journal of Psychiatry 146 (1985), 348-357.
40. A. Lane, K. Colgan, F. Moynihan, T. Burke, J.L. Waddington, C. Larkin and E. O'Callaghan, Schizophrenia and neurological soft signs: Gender differences in clinical correlates and antecedent factors, Psychiatry Research 64 (1996), 105-114.
41. B.E. Lippitz, P. Mindus, B.A. Meyerson, L. Kihlstrom, C. Lindquist, L.D. Lunsford, P.L. Gildenberg, P.J. Kelly and R.A.E. Bakay, Lesion Topography and outcome after thermocapsulotomy or gamma knife capsulotomy for obsessive-compulsive disorder: Relevance of the right hemisphere, Neurosurgery 44 (1999), 452-160.
42. A.K. Malla, R.M. Norman, O. Aguilar and L. Cortese, Relationship between neurological 'soft signs' and syndromes of schizophrenia, Acta Psychiatrica Scandinavica 96 (1997), 274-280.
43. P. Martin, M. Tewesmeier, M. Albers, G.B. Schmid and C. Scharfetter, Towards an understanding of sensory soft signs of schizophrenia, Psychopathology 28 (1995), 281-284.
44. J.E. Max, W.L. Smith, S.D. Lindgren, D.A. Robin, P. Mattheis, J. Stierwalt and M. Morrisey, Case study: obsessive compulsive disorder after severe traumatic head injury in an adolescent, Journal of the American Academy of Child and Adolescent Psychiatry 34 (1995), 45-49.
45. J. McKeon, P. McGuffin and P. Robinson, Obsessive-compulsive neurosis following head injury: a report of four cases, British Journal of Psychiatry 144 (1984), 190-192.
46. F. Mohr, W. Hubmann, W. Bender, C. Haslacher, S. Honicke, R. Schlenker, C. Wahlheim and P. Werther, Neurological soft signs in schizophrenia: assessment and correlates, European Archives of Psychiatry and Clinical Neuroscience 246 (1996), 240-248.
47. H.E. Nelson, The National Adult Reading Test, Windsor, NFER-Nelson, 1982.
48. D. Pauls, K. Towbin, J. Leckman, G. Zahner and D. Cohen, Gilles de la Tourette syndrome and obsessive-compulsive disorder: evidence supporting an etiological relationship, Archives of General Psychiatry 43 (1986), 1180-1182.
49. B.S. Peterson, Neuroimaging in child and adolescent neuropsychiatric disorders, Journal of the American Academy of Child and Adolescent Psychiatry 34 (1995), 1560-1576.
50. R. Purcell, P. Maruff, M. Kyrios and C. Pantelis, Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function, Biological Psychiatry 43 (1998), 348-356.
51. F. Quitkin, A. Rifkin and D.F. Klein, Neurologic soft signs in schizophrenia and character disorders, Archives of General Psychiatry 33 (1976), 845-853.
52. J.L. Rapoport, Obsessive compulsive disorder and basal ganglia dysfunction, Psychological Medicine 20 (1990), 465-469.
53. S.L. Rauch and M.A. Jenike, Neurobiological models of obsessive-compulsive disorder, Psychosomatics 34 (1993), 20-32.
54. D. Robinson, H. Wu, R.A. Munne, M. Ashtari, J. Alvir, G. Lemer, A. Koreen, K. Cole and B. Bogerts, Reduced caudate nucleus volume in obsessive-compulsive disorder, Archives of General Psychiatry 52 (1995), 393-398.
55. D.R. Rosenberg and M.S. Keshavan, Towards a neurodevelopmental model of obsessive-compulsive disorder, Biological Psychiatry 43 (1998), 623-640.
56. G.V. Sawle, N.F. Hymas, A.J. Lees and R.S.J. Frackowiak, Obsessional slowness: Functional studies with positron emission tomography, Brain 114 (1991), 2191-2202.
57. R.D. Sanders and M.S. Keshavan, The neurologic examination in adult psychiatry: From hard signs to soft science, Journal of Neuropsychiatry 10 (1998), 395-404.
58. S.L. Santangelo, D.L. Pauls, J.M. Goldstein, S.V. Faraone, M.T. Tsuang and J.F. Leckman, Tourette's Syndrome: what are the influences of gender and comorbid obsessive-compulsive disorder?, Journal of the American Academy of Child and Adolescent Psychiatry 33 (1994), 795-804.
59. S. Saxena, A.L. Brody, J.M. Schwartz and L.R. Baxter, Neuroimaging and frontal-subcortical circuitry in obsessive compulsive disorder, British Journal of Psychiatry 173 (1998), 26-37.
60. P. Schilder, The organic background of obsessions and compulsions, American Journal of Psychiatry 94 (1938), 1397-1416.
61. I.S. Schoenfeld, D. Shaffer and J.E. Barmack, Neurological Soft Signs and School Achievement: The mediating effects of sustained attention, Journal of Abnormal Child Psychology 17 (1989), 575-596.
62. J. Schröder, R. Niethammer, F. Geider, C. Reitz, M. Binkert, M. Jauss and H. Sauer, Neurological soft signs in schizophrenia, Schizophrenia Research 6 (1992), 25-30.
63. J. Schröder, M.S. Buchsbaum, B.V. Siegal, F.J. Geider and R. Neithammer, Structural and functional correlates of subsyndromes in chronic schizophrenia, Psychopathology 23 (1995), 38-45.
64. J. Schröder, A. Tittel, A. Stockert and M. Kerr, Memory deficits in subsyndromes of schizophrenia, Schizophrenia Research 21 (1996), 19-26.
65. D. Shaffer, I. Schonfeld, P.A. O'Connor, C. Stokman, P. Trautman, S. Shafer and I. Ng, Neurological soft signs and their relationship to psychiatric disorder: Their relationship to psychiatric disorder and intelligence in childhood and adolescence, Archives of General Psychiatry 42 (1985), 342-351.
66. R.C. Smith and R.P. Kadewari, Neurological soft signs and response to Risperidone in chronic schizophrenia, Biological Psychiatry 40 (1996), 1056-1059.
67. SPSS for Windows, Release 8.0.0. Chicago, SPSS Inc., 1997.
68. D.J. Stein, E. Hollander, D. Simeon, L. Cohen, M.N. Islam and B. Aronowitz, Neurological soft signs in female trichotillomania patients, obsessive compulsive disorder patients, and healthy control subjects, Journal of Neuropsychiatry 6 (1994), 184-187.
69. S.E. Swedo, J.L. Rapoport, D.L. Cheslow, H.L. Leonard, E.M. Ayoub, D.M. Hosier and E.R. Wald, High prevalence of obsessive-compulsive symptoms in patients with Sydenham's chorea, American Journal of Psychiatry 146 (1989), 246-249.
70. M. Thienemann and L.M. Koran, Do soft signs predict treatment outcome in obsessive-compulsive disorder?, Journal of Neuropsychiatry and Clinical Neurosciences 7 (1995), 218-222.
71. B. Vitiello, A.J. Ricciuti, D.M. Stoff, D. Behar and M. Denckla, Reliability of subtle (soft) neurological signs in children, Journal of the American Academy of Child and Adolescent Psychiatry 28 (1989), 749-753.
72. C. Von Economo, Encephalitis Lethargica: its sequellae and treatment, Oxford University Press, Oxford, 1931.
73. E. Walker and M. Green, Soft signs of neurological dysfunction in schizophrenia: an investigation of lateral performance, Biological Psychiatry 17 (1982), 381-386.
74. D.R. Weinberger, K.F. Berman and R.F. Zec, Physiological dysfunction of dorsolateral prefrontal coretx in schizophrenia. I. Regional cerebral blood flow evidence, Archives of General Psychiatry 43 (1986), 114-124.
75. D.R. Weinberger, K.F. Berman and B.P. Illowsky, Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism, Archives of General Psychiatry 45 (1988), 609-615.
76. J.T. Winslow and T. Insel, Neuroethological models of obsessive-compulsive disorder, in: The Psychobiology of Obsessive-compulsive disorder, J. Zohar, T. Insel and S. Rasmussen, eds, Spinger Verlag, New York, 1991, pp. 208-226.
77. J.A. Yaryura-Tobias, T.A. Campisi, D. McKay and F.A. Neziroglu, Schizophrenia and obsessive compulsive disorder: shared aspects of pathology, Neurology, Psychiatry and Brain Research 3 (1995), 143-148.
78. D.H. Zald and S.W. Kim, Anatomy and function of the orbital frontal cortex, II: Function and relevance to obsessive compulsive disorder, Journal of Neuropsychiatry 8 (1996), 249-261.