Genomic medicine and lung diseases

American Journal of Respiratory and Critical Care Medicine

Volumn 186, Issue 3, 2012, Pages 280-285

  Center, David M ^a   Schwartz, David A ^b   Solway, Julian ^c   Gail, Dorothy ^d   Laposky, Aaron D ^d   Lin, Qing S ^d   Gan, Weiniu ^d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO HOSPITAL   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Data sharing; Drug repurposing; Epigenetics; Molecular networks; Molecular phenotypes

Indexed keywords

DNA; MICRORNA; RNA;

CANCER CELL CULTURE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL DATA REPOSITORY; CONFERENCE PAPER; DNA METHYLATION; ELECTRONIC MEDICAL RECORD; FIBROSING ALVEOLITIS; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; GENETIC ASSOCIATION; GENOMICS; HUMAN; MASS SPECTROMETRY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS;

EDUCATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOMICS; HUMANS; LUNG DISEASES; NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (U.S.); UNITED STATES;

EID: 84864523771     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201203-0569WS     Document Type: Conference Paper

References (26)

1. Konishi K, Gibson KF, Lindell KO, Richards TJ, Zhang Y, Dhir R, Bisceglia M, Gilbert S, Yousem SA, Song JW, et al. Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009;180:167-175.
2. Pandit KV, Milosevic J, Kaminski N. MicroRNAs in idiopathic pulmonary fibrosis. Transl Res 2011;157:191-199.
3. Kass DJ, Kaminski N. Evolving genomic approaches to idiopathic pulmonary fibrosis: moving beyond genes. Clin Transl Sci 2011;4:372-379.
4. Richards TJ, Kaminski N, Baribaud F, Flavin S, Brodmerkel C, Horowitz D, Li K, Choi J, Vuga LJ, Lindell KO, et al. Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2012;185:67-76.
5. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009;180:388-395.
6. Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011;365:1088-1098.
7. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med 2011;184:1153-1163.
8. Coon KD, Dunckley TL, Stephan DA. A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders. Mol Diagn Ther 2007;11:1-14.
9. Littman BH, Di Mario L, Plebani M, Marincola FM. What's next in translational medicine? Clin Sci (Lond) 2007;112:217-227.
10. Littman BH, Marincola FM. Create a translational medicine knowledge repository-research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons? J Transl Med 2011;9:56.
11. Cohen AL, Soldi R, Zhang H, Gustafson AM, Wilcox R, Welm BE, Chang JT, Johnson E, Spira A, Jeffrey SS, et al. A pharmacogenomic method for individualized prediction of drug sensitivity. Mol Syst Biol 2011;7:513.
12. Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med 2011;3:96.
13. Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med 2011;3:96.
14. Chaurand P, Cornett DS, Angel PM, Caprioli RM. From whole-body sections down to cellular level, multiscale imaging of phospholipids by MALDI mass spectrometry.Mol Cell Proteomics 2011;10:O110.004259.
15. Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I. Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics. Curr Opin Pulm Med 2011;17:279-285.
16. Naidoo N. Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev 2009;13:195-204.
17. Stringer KA, Serkova NJ, Karnovsky A, Guire K, Paine R III, Standiford TJ. Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol 2011;300:L4-L11.
18. Serkova NJ, Standiford TJ, Stringer KA. The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses. Am J Respir Crit Care Med. 2011;184:647-655.
19. Murphy A, Chu JH, Xu M, Carey VJ, Lazarus R, Liu A, Szefler SJ, Strunk R, Demuth K, Castro M, et al. Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD41 lymphocytes. Hum Mol Genet 2010;19:4745-4757.
20. Chu JH, Lazarus R, Carey VJ, Raby BA. Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes. BMC Syst Biol 2011;5:89.
21. Bellet MM, Sassone-Corsi P. Mammalian circadian clock and metabolism - the epigenetic link. J Cell Sci 2010;123:3837-3848.
22. Milne CB, Eddy JA, Raju R, Ardekani S, Kim PJ, Senger RS, Jin YS, Blaschek HP, Price ND. Metabolic network reconstruction and genome-scale model of butanol-producing strain Clostridium beijerinckii NCIMB 8052. BMC Syst Biol 2011;5:130.
23. Lefebvre C, Rajbhandari P, Alvarez MJ, Bandaru P, Lim WK, Sato M, Wang K, Sumazin P, Kustagi M, Bisikirska BC, et al. A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers. Mol Syst Biol 2010;6:377.
24. Franks TJ, Colby TV, Travis WD, Tuder RM, Reynolds HY, Brody AR, Cardoso WV, Crystal RG, Drake CJ, Engelhardt J, et al. Resident cellular components of the human lung: current knowledge and goals for research on cell phenotyping and function. Proc Am Thorac Soc 2008;5:763-766.
25. Hackett NR, Shaykhiev R, Walters MS, Wang R, Zwick RK, Ferris B, Witover B, Salit J, Crystal RG. The human airway epithelial basal cell transcriptome. PLoS ONE 2011;6:e18378.
26. Friend SH. Something in common. Sci Transl Med 2010;2:40ed6.