Kit formulation for 99mTc-labeling of HYNIC-ΒAla-Bombesin (7-14)

Applied Radiation and Isotopes

Volumn 70, Issue 10, 2012, Pages 2440-2445

  de Barros, André Luís Branco ^a   Mota, Luciene das Graças ^a   Ferreira, Carolina de Aguiar ^a   Cardoso, Valbert Nascimento ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Bombesin; Freeze drying lyophilization; Kit formulation; Radiolabeling; Technetium 99m

Indexed keywords

BOMBESIN; FREEZE-DRYING/LYOPHILIZATION; KIT FORMULATION; RADIOLABELING; TECHNETIUM-99M;

BAYESIAN NETWORKS; TECHNETIUM;

PEPTIDES;

2 HYDRAZINONICOTINAMIDE BETA ALANINE BOMBESIN(7-14); BOMBESIN DERIVATIVE; TECHNETIUM 99M; UNCLASSIFIED DRUG; BOMBESIN; BOMBESIN RECEPTOR; DRUG DERIVATIVE; TECHNETIUM COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SPECIFICITY; DRUG STABILITY; FREEZE DRYING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIOACTIVITY; RADIOCHEMISTRY; SCINTIGRAPHY; CHEMISTRY; HUMAN; METABOLISM; NEOPLASM; TISSUE DISTRIBUTION;

BOMBESIN; FREEZE DRYING; HUMANS; NEOPLASMS; ORGANOTECHNETIUM COMPOUNDS; RECEPTORS, BOMBESIN; TISSUE DISTRIBUTION;

EID: 84864512242     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.06.022     Document Type: Article

References (36)

1. 99mTc-labeling of recombinant anti-HER2 affibody molecules with a C-terminally engineered cysteine. Nucl. Med. Biol. 2010, 37:539-546.
2. 68Gallium-DOTA-peptides in NET: an overview. Eur. J. Radiol. 2011, 80:e116-e119.
3. 99mTechnetium-HYNIC(tricine/TPPTS)-Aca-Bombesin(7-14) as a targeted imaging agent with microSPECT in a PC-3 prostate cancer xenograft model. Mol. Pharm. 2011, 8:1165-1173.
4. Anastasi A., Erspamer V., Bucci M. Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 1971, 27:166-167.
5. de Barros A.L.B., Cardoso V.N., Mota L.G., Leite E.A., Oliveira M.C., Alves R.J. Synthesis and biological evaluation of technetium-labeled d-glucose-MAG3 derivative as agent for tumor diagnosis. Bioorg. Med. Chem. Lett. 2009, 19:2497-2499.
6. de Barros A.L.B., Cardoso V.N., Mota L.G., Leite E.A., Oliveira M.C., Alves R.J. A novel d-glucose derivative radiolabeled with technetium-99m: synthesis, biodistribution studies and scintigraphic images in an experimental model of Ehrlich tumor. Bioorg. Med. Chem. Lett. 2010, 20:2478-2480.
7. de Barros A.L.B., Mota L.G., Ferreira C.A., Oliveira M.C., Góes A.M., Cardoso V.N. Bombesin derivative radiolabeled with technetium-99m as agent for tumor identification. Bioorg. Med. Chem. Lett. 2010, 20:6182-6184.
8. Chen X., Li L., Liu F., Liu B. Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor. Bioorg. Med. Chem. Lett. 2006, 16:5503-5506.
9. 18F]-FDG in oncology: a clinical uptake. Nucl. Med. Biol. 1996, 23:717.
10. 111In-minigastrin in female nude mice transplanted with medullary thyroid carcinoma GOT2. Oncol. Rep. 2012, 27:174-181.
11. 99mTc-labeled bombesin analogues improves their pharmacokinetic properties. Nucl. Med. Biol. 2011, 38:997-1009.
12. Faintuch B.L., Teodoro R., Duatti A., Muramoto E., Faintuch S., Smith C.J. Radiolabeled bombesin analogs for prostate cancer diagnosis: preclinical studies. Nucl. Med. Biol. 2008, 35:401-411.
13. 3-Bombesin. Appl. Radiat. Isot. 2010, 68:2274-2278.
14. 99mTc/EDDA/tricine/HYNIC0, 1-Nal3, Thr8]-octreotide as a new analogue in the detection of somatostatin-receptor-positive tumors. Nucl. Med. Biol. 2007, 34:651-657.
15. Guo H., Xie F., Zhu M., Li Y., Yang Z., Wang X., Lu J. The synthesis of pteroyl-lys conjugates and its application as Technetium- 99m labeled radiotracer for folate receptor-positive tumor targeting. Bioorg. Med. Chem. Lett. 2011, 21:2025-2029.
16. Jensen R.T., Battley J.F., Spindel E.R., Benya R.V. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol. Rev. 2008, 60:1-42.
17. Koopmans K.P., Neels O.N., Kema I.P., Elsinga P.H., Links T.P., Vries E.G.E., Jager P.L. Molecular imaging in neuroendocrine tumors: molecular uptake mechanisms and clinical results. Crit. Rev. Oncol. Hematol. 2009, 71:199-213.
18. Kowalsky R.J., Dalton D.R. Technical problems associated with the production of technetium-99m tin(II) pyrophosphate kits. Am. J. Hosp. Pharm. 1981, 38:1722-1726.
19. Lee Y.S., Jeong J.M., Kim Y.J., Chang Y.S., Lee H.J., Son M., Lee J.W., Yoon H.S., Kang W.J., Lee D.S., Chung J.K., Lee M.C., Suh Y.G. Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol. Appl. Radiat. Isot. 2007, 65:64-69.
20. Liu S. Radiolabeled cyclic RGD paptides as integrin avb3-targeted radiotracers: maximizing binding affinity via bivalency. Bioconjug. Chem. 2009, 20:2199-2213.
21. Lu J., Pang Y., Xie F., Guo H., Li Y., Yang Z., Wang X. Synthesis and in vitro/in vivo evaluation of (99m)Tc-labeled folate conjugates for folate receptor imaging. Nucl. Med. Biol. 2011, 38:557-565.
22. Miranda-Olvera A.D., Ferro-Flores G., Pedraza-López M., Murphy C.A., Léon-Rodriguez L.M. Synthesis of oxytocin HYNIC derivatives as potential diagnosis agents for breast câncer. Bioconjug. Chem. 2007, 18:1560-1567.
23. 99mTc]Domobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging. Eur. J. Nucl. Med. 2003, 30:247-258.
24. 99mTc-labelled gold nanoparticles capped with HYNIC-peptide/mannose for sentinel lymph node detection. Nucl. Med. Biol. 2011, 38:1-11.
25. Okarvi S.M., Al-Jammaz I. Synthesis, radiolabelling and biological characteristics of a bombesin peptided analog as a tumor imaging agent. Anticancer Res. 2003, 23:2745-2750.
26. Okarvi, S.M., Jammaz, I.A. Preparation and evaluation of bombesin peptide derivatives as potential tumor imaging agents: effects of structure and composition of amino acid sequence on in vitro and in vivo characteristics. Nucl. Med. Biol., , in press. http://dx.doi.org/10.1016/j.nucmedbio.2012.01.002.
27. Reubi J.C. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr. Rev. 2003, 24:389-427.
28. 2-Tat(49-57)-Bombesin: a target-specific hybrid radiopharmaceutical. Int. J. Pharm. 2009, 375:75-83.
29. 99mTc-N2S2-Tat(49-57)-Bombesin internalized in nucleio f prostate and breast cancer cells: kinetics, dosimetry and effects on cellular proliferation. Nucl. Med. Commun. 2011, 32:303-313.
30. 99mTc-N3S-X-BBN[7-14]NH2: an in vitro/in vivo struture-activity relationship study where X=0-, 3-, 5-, 8- and 11-carbon tethering moieties. Bioconjug. Chem. 2003, 14:93-102.
31. Smith C.J., Volkert W.A., Hoffman T.J. Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes. Nucl. Med. Biol. 2005, 32:733-740.
32. Smyth D.R., Tsorpelas C. An improved 99mTc-aprotinin kit formulation: quality control analysis of radiotracer stability and cold kit shelf life. Nucl. Med. Biol. 2005, 32:885-889.
33. 99mTc radiolabeling. J. Med. Chem. 2007, 50:1418-1422.
34. Virgolini I.J., Gabriel M., Guggenberg E.V., Putzer D., Kendler D., Decristoforo C. Role of radiopharmaceutical in the diagnosis and treatment of neuroendocrine tumours. Eur. J. Cancer 2009, 45:274-291.
35. Zhang K., Aruva M.R., Shanthly N., Cardi C.A., Patel C.A., Rattan S., Cesarone G., Wickstrom E., Thakur M.L. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation. Regul. Pept. 2007, 144:91-100.
36. Zhang K., Aruva M.R., Shanthly N., Cardi C.A., Rattan S., Patel C., Kim C., McCue P.A., Wickstrom E., Thakur M.L. PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer. J. Nucl. Med. 2008, 49:112-121.