Cochinchina momordica seed extract induces G2/M arrest and apoptosis in human breast cancer mda-mb-231 cells by modulating the PI3K/AKT pathway

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 12, 2011, Pages 3483-3488

  Meng, Lin Yi ^a,b,c   Liu, Hong Rui ^b   Shen, Yang ^c   Yu, Yun Qiu ^d   Tao, Xia ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Pharmacology ^*  (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

Author keywords

Anticancer activity; Apoptosis; Cell cycle; Cochinchina momordica seeds; MDA MB 231 cell; PI3K Akt

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN BAX; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; BREAST TUMOR; CELL CYCLE G2 PHASE; CELL DIVISION; CHEMISTRY; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; MOMORDICA; PATHOLOGY; PLANT SEED; TUMOR CELL CULTURE; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BREAST NEOPLASMS; CASPASE 3; CELL DIVISION; FEMALE; G2 PHASE; HUMANS; MOMORDICA; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; SEEDS; TUMOR CELLS, CULTURED;

EID: 84864504927     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Asnaghi L, Calastretti A, Bevilacqua A, et al (2004). Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. Oncogene, 23, 5781-91
2. Basseres DS, Baldwin AS (2006). Nuclear factor-?B and inhibitor of ?B kinase pathways in oncogenic initiation and progression. Oncogene, 25, 6817-30
3. Bolognesi A, Barbieri L, Carnicelli D, et al (1989). Purification and properties of a new ribosome-inactivating protein with RNA N-glycosidase activity suitable for immunotoxin preparation from the seeds of Momordica cochinchinensis. Biochim. Biophys. Acta, 93, 287
4. Bosch FX, Ribes J, Diaz M, et al (2004). Primary liver cancer: worldwide incidence and trends. Gastroenterology, 127, 5-16
5. Burstein E, Duckett CS (2003). Dying for NF?B? Control of cell death by transcriptional regulation of the apoptotic machinery. Curr Opin Cell Biol, 15, 732-7
6. Chao JI, Kuo PC, Hsu TS (2004). Down-regulation of survivin in nitric oxide induced cell growth inhibition and apoptosis of the human lung carcinoma cells. J Biol Chem, 279, 20267-76
7. Cilloni D, Martinelli G, Messa F, Baccarani M, Saglio G (2007). Nuclear factor-?B as a target for new drug development in myeloid malignancies. Haematologica, 92, 1224-9
8. DL Vaux, Korsmeyer SJ (1999). Cell death in development. Cell, 96, 245-54
9. Parkin DM, Fernández LM (2006). Use of statistics to assess the global burden of breast cancer. Breast J, 12, S70-80
10. Dash BC, El-Deiry WS (2005). Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity. Mol Cell Biol, 25, 3364-8
11. Dutta J, Fan Y, Gupta N, Fan G, Gelinas C (2006). Current insights into the regulation of programmed cell death by NF?B. Oncogene, 25, 6800-16
12. Emi M, Kim R, Tanabe K, et al (2005). Targeted therapy against Bcl-2-related proteins in breast cancer cells. Breast Cancer Res, 7, R940-52
13. Gupta S, Afaq F, Mukhtar H (2002). Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells. Oncogene, 21, 3727-38
14. Heimlich G, McKinnon AD, Bernardo K, et al (2004). Bax-induced cytochrome c release from mitochondria depend sonalpha-helices-5 and-6. Biochem J, 378, 247-55
15. Hengartner MO (2000). The biochemistry of apoptosis. Nature, 407, 770-6
16. Hidalgo A, Ffrench-Constant C (2003). The control of cell number during central nervous system development in flies and mice. Mech Dev, 120, 1311-25
17. Iwamoto M, Okabe H, Yamauchi T, et al (1985). Studies on the constituents of Momordica cochinchinensis Spreng I. Isolation and characterization on the seed saponins, momordica saponins I and II. Chem Pharm Bull, 33, 464
18. JJ Barron, R Quimbo, PT Nikam, et al (2008). Assessing the economic burden of breast cancer in a US managed care population. Breast Cancer Res Treat, 109, 367-77
19. JM Brown, Wouters BG (1999). Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res, 59, 1391-9
20. Jost PJ, Ruland J (2007). Aberrant NF?B signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood, 109, 2700-7
21. Kang JM, Kim N, Kim B, et al (2010). Enhancement of Gastric Ulcer Healing and Angiogenesis by Cochinchina Momordica Seed Extract in Rats. J Korean Med Sci, 25, 875-81
22. Katayama K, Fujita N, Tsuruo T (2005). Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Mol Cell Biol, 25, 5725-37
23. Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, et al (1997). Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature, 385, 544-8
24. Kundu T, Dey S, Roy M, et al (2005). Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. Cancer Letters, 230, 111-21
25. Luo JL, Kamata H, Karin M (2005b). The anti death machinery in IKK/NF?B signaling. J Clin Immunol, 25, 541-50
26. Melisi D, Chiao PJ (2007). NF?B as a target for cancer therapy. Exp Opin Ther Targ, 11, 133-44
27. Murakami T, Nagasawa H, Itokawa H, et al (1966). The structure of a new triterpene, momordic acids, obtained from momordica cochinchinensis sprenger. Tetrahedron Letters, 42, 5137
28. Oltersdorf T, Elmore SW, Shoemaker AR, et al (2005). An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature, 435, 677-81
29. Pu L, Amoscato AA, Bier ME, Lazo JS (2002). Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5, 8-dione. J Biol Chem, 277, 46877-85
30. Rajput ZI, Xiao CW, Hu SH, Arijo AG, Soomro NM (2007). Improvement of the efficacy of influenza vaccination (H5N1) in chicken by using extract of cochinchina momordica seed (ECMS). J Zhejiang Univ Sci, B8, 331-7
31. Romashkova JA, Makarov SS (1999). NF-?B is a target of AKT in anti-apoptotic PDGF signaling. Nature, 401, 86-90
32. Stirpe Fiorenzo, Barbieri Luigi, Gromo Gianni (1990). Ribisome inactivating proteins for use in immunotoxins. Eur Pat Apple EP, 3, 390
33. Thees S, Hubbard GB, Winckler J, et al (2005). Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restor Neurol Neurosci, 23, 1-9
34. Tsoi AY, Ng T-B, Fong W-P (2005). Antioxidative effect of a chymotrypsin inhibitor from Momordica cochinchinensis (Cucurbitaceae) seeds in a primary rat hepatocyte culture. J Peptide Sci, 11, 665-8
35. Vickers A (2002). Botanical medicines for the treatment of cancer: rationale, overview of current data, and methodological considerations for phase I and II trials. Cancer Investigation, 20, 1069-79
36. Vivanco I, Sawyers CL (2002). The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer, 2, 489-501
37. Wang W, Niu Z, Wang Y (2000). Studies on Fatty Acid Composition in the Oil of Momordica cochinchinensis. Chinese Traditional and Herbal Drugs, 31, 727
38. Wang Y, Ji P, Liu J, et al (2009). Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy. Mol Cancer, 8, 8
39. Weir NM, Selvendiran K, Kutala VK, et al (2007). Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther, 6, 178-84
40. Wyllie AH, Kerr JF, Currie AR (1980). Cell death: the significance of apoptosis. 68, 251-306
41. Xiao C Rajput ZI, Liu D, Hu S (2007). Enhancement of serological immune responses to foot-and-mouth disease vaccine by a supplement made of extract of cochinchinamomordica seeds. Clin Vaccine Immunol, 14, 1634-9
42. Yeung HW (1987). Isolation and characterization of an abortifacient protein, Momorcochin, from root tubers of Momordica cochinchinenses (Family Cucurbitacese). Int Peptide Protein Res, 30, 135