A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins

Human Molecular Genetics

Volumn 21, Issue 15, 2012, Pages 3374-3386

  Eykelenboom, Jennifer E ^a,c   Briggs, Gareth J ^a   Bradshaw, Nicholas J ^a,d   Soares, Dinesh C ^a   Ogawa, Fumiaki ^a   Christie, Sheila ^a   Malavasi, Elise L V ^a   Makedonopoulou, Paraskevi ^a   Mackie, Shaun ^a   Malloy, Mary P ^a   Wear, Martin A ^a   Blackburn, Elizabeth A ^a   Bramham, Janice ^a   Mcintosh, Andrew M ^a,b   Blackwood, Douglas H ^a,b   Muir, Walter J ^a,b   Porteous, David J ^a   Millar, J Kirsty ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ROYAL EDINBURGH HOSPITAL   (United Kingdom)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^d UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CHIMERIC PROTEIN; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; HYBRID PROTEIN; MITOCHONDRIAL PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN; CELL LINE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; GENE DISRUPTION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC RISK; HAPLOINSUFFICIENCY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOOD DISORDER; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SCHIZOPHRENIA;

ANIMALS; CERCOPITHECUS AETHIOPS; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 11; COS CELLS; HAPLOINSUFFICIENCY; HUMANS; MITOCHONDRIAL PROTEINS; MOOD DISORDERS; NERVE TISSUE PROTEINS; SCHIZOPHRENIA; TRANSFECTION; TRANSLOCATION, GENETIC;

EID: 84864501555     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds169     Document Type: Article

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