Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 385, Issue 8, 2012, Pages 777-786

  Meini, S ^a   Cucchi, P ^a   Tinti, L ^b   Niccolini, S ^b   Bellucci, F ^a   Catalani, C ^a   Valenti, C ^a   Galeazzi, M ^b   Fioravanti, A ^b   Maggi, C A ^a  

^a Menarini Ricerche SpA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

B2receptor; Bradykinin; Cyclooxygenase; Fasitibant; Interleukin 1 ; Kinin; Knee; MEN16132; Osteoarthritis; Synovium

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL PHOSPHATE; INTERLEUKIN 1BETA; MEN 16132; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; INCUBATION TIME; OSTEOARTHRITIS; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; SYNOVIOCYTE;

BLOTTING, WESTERN; BRADYKININ; CYCLOOXYGENASE 2; DINOPROSTONE; DNA, COMPLEMENTARY; ENZYME INHIBITORS; FIBROBLASTS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; INTERLEUKIN-1BETA; ORNITHINE; RADIOLIGAND ASSAY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, BRADYKININ B2; RNA; SULFONAMIDES; SYNOVIAL FLUID;

EID: 84864493208     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-012-0762-y     Document Type: Article

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