Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1β, but not by TNFα

Rheumatology International

Volumn 27, Issue 10, 2007, Pages 911-917

  Alvarez Soria, M Angeles ^a   Largo, Raquel ^a   Sanchez Pernaute, Olga ^a   Calvo, Emilio ^a   Egido, Jesús ^a   Herrero Beaumont, Gabriel ^a,b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Chondrocytes; COX 2; EP receptors; IL 1; NSAID

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; DOSE RESPONSE; GENE EXPRESSION; INFLAMMATION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RABBIT; UPREGULATION;

ANIMALS; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; INTERLEUKIN-1BETA; KNEE JOINT; RABBITS; RECEPTORS, PROSTAGLANDIN E; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 34447536849     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-007-0328-3     Document Type: Article

References (33)

1. Abramson SB, Attur M, Amin AR, Clancy R (2001) Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep 3:535-541
2. Calvo E, Palacios I, Delgado E, Sánchez O, Hernández P, Ruiz-Cabello J, Moreno J, Egido J, Herrero-Beaumont G (2001) High resolution MRI shows that increased cartilage thickness precedes subchondral remodeling in experimental osteoarthritis. Osteoarthritis Cartilage 9:463-472
3. Barakat AF, Elson CJ, Westacott CI (2002) Susceptibility to physiological concentrations of IL-1beta varies in cartilage at different anatomical locations on human osteoarthritic knee joints. Osteoarthritis Cartilage 10:264-269
4. Martel-Pelletier J, Pelletier JP, Fahmi H (2003) Cyclooxygenase-2 and prostaglandins in articular tissues. Sem Arthritis Rheum 33:155-167
5. Amin AR, Attur MG, Abramson SB (1999) Regulation of nitric oxide and inflammatory mediators in human osteoarthritis-affected cartilage: implication for pharmacological intervention. In: Rubanyi GM (ed) The pathophysiology and clinical applications of nitric oxide. Harwood Academic Newark, pp 397-413
6. Lotz M (2001) Cytokines in cartilage injury and repair. Clin Orthop Suppl 391:S108-S115
7. Vincenti MP, Brinckerhoff CE (2001) Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1 beta. Arthritis Res Ther 3:381-388
8. Berenbaum F, Jacques C, Thomas G, Corvol MT, Bereziat G, Masliah J (1996) Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on PGE2 production by articular chondrocytes does not involve PLA2 stimulation. Exp Cell Res 222:379-384
9. Amin AR, Attur M, Patel RN, Thakker GD, Marshall PJ, Rediske J, Stuchin SA, Patel IR, Abramson SB (1997) Superinduction of COX-2 activity in human osteoarthritic affected cartilage: Influence of nitric oxide. J Clin Invest 99:1231-1237
10. Goetzl EJ, An S, Smith WL (1995) Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases. FASEB J 9:1051-1058
11. Breyer RM, Bagdassarian CK, Myers SA, Breyer MD (2001) Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41:661-690
12. Largo R, Díez-Ortego I, Sanchez-Pernaute O, Lopez-Armada MJ, Alvarez-Soria MA, Egido J, Herrero-Beaumont G. (2004) EP2/EP4 signalling inhibits monocyte chemoattractant protein-1 production induced by interleukin 1beta in synovial fibroblasts. Ann Rheum Dis 63:1197-1204
13. Narumiya S, Sugimoto Y, Ushikubi F (1999) Prostanoid receptors: structures, properties, and functions. Physiol Rev 79:1193-1226
14. Akaogi J, Yamada H, Kuroda Y, Nacionales DC, Reeves WH, Satoh M (2004) Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production. J Leukoc Biol 76:227-236
15. Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sanchez-Pernaute O, Egido J, Herrero-Beaumont G (2003). Glucosamine inhibits IL-1beta-induced NFkB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 11:290-298
16. Reginato AM, Lozzo RV, Jimenez SA (1994). Formation of nodular structures resembling mature articular cartilage in long-term primary cultures of human fetal epiphyseal chondrocytes on a hydrogel substrate. Arthritis Rheum 37:1338-1349
17. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocynate-phenolchloroform extraction. Anal Biochem 162:152-159
18. Guan Y, Chan M, Cho W, Zhang Y, Redha R, Davis L, Chang S, DuBois RN, Hao CM, Breyer M (1997) Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells. Am J Physiol 273:F18-F16
19. Guan Y, Zhang Y, Breyer RM, Fowler B, Davis L, Hebert RL, Breyer MD (1998) Prostaglandin E2 inhibits renal collecting duct Na+ absorption by activating the EP1 receptor. J Clin Invest 102:194-201
20. Breyer RM DL, Nian C, Redha R, Stillman B, Jacobson HR, Breyer MD (1996) Cloning and expression of the rabbit prostaglandin EP4 receptor. Am J Physiol 270:F485-F493
21. Bertolini A, Ottani A, Sandrini M (2001) Dual acting anti-inflammatory drugs: a reappraisal. Pharmacol Res 44:437-450
22. Fulkerson JP, Damiano P (1983) Effect of prostaglandin E2 on adult pig articular cartilage slices in culture. Clin Orthop Relat Res 179:266-269
23. Noguchi K, Shitashige M, Endo H, Kondo H, Ishikawa I (2002) Binary regulation of interleukin-6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1 -stimulated human gingival fibroblasts. J Periodontal Res 37:29-36
24. Yamane H, Sugimoto Y, Tanaka S, Ichikawa A (2000) Prostaglandin E(2) receptors, EP2 and EP4, differentially modulate TNF-alpha and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils. Biochem Biophys Res Commun 278:224-228
25. Fehrenbacher JC, Burkey TH, Nicol GD, Vasko MR (2005) Tumor necrosis factor alpha and interleukin-1beta stimulate the expression of cyclooxygenase II but do not alter prostaglandin E(2) receptor mRNA levels in cultured dorsal root ganglia cells. Pain 113:113-122
26. Spaziani EP, Benoit RR, Tsibris JC, Gould SF, O'Brien WF (1998) Tumor necrosis factor-alpha upregulates the prostaglandin E2 EP1 receptor subtype and the cyclooxygenase-2 isoform in cultured amnion WISH cells. J Interferon Cytokine Res 18:1039-1044
27. De Brum-Fernandes AJ, Morisset S, Bkaily G, Patry C (1996) Characterization of the PGE2 receptor subtype in bovine chondrocytes in culture. Br J Pharmacol 118:1597-1604
28. Miyamoto M, Ito H, Mukai S, Kobayashi T, Yamamoto H, Kobayashi M, Maruyama T, Akiyama H, Nakamura T (2003) Simultaneous stimulation of EP2 and EP4 is essential to the effect of prostaglandin E2 in chondrocyte differentiation. Osteoarthritis Cartilage 11:644-652
29. Malfait AM, Verbruggen G, Veys EM, Lambert J, De Ridder L, Cornelissen M (1994) Comparative and combined effects of interleukin 6, interleukin 1 beta, and tumor necrosis factor alpha on proteoglycan metabolism of human articular chondrocytes cultured in agarose. J Rheumatol 21:314-320
30. Sylvia VL, Del Toro F Jr, Hardin RR, Dean DD, Boyan BD, Schwartz Z (2001) Characterization of PGE(2) receptors (EP) and their role as mediators of 1alpha,25-(OH)(2)D(3) effects on growth zone chondrocytes. J Steroid Biochem Mol Biol 78:261-274
31. Fushimi K, Nakashima S, Banno Y, Akaike A, Takigawa M, Shimizu K (2004) Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. Osteoarthritis Cartilage 12:895-903
32. Gomez-Barrena E, Sánchez-Pernaute O, Largo R, Calvo E, Esbrit P, Herrero-Beaumont G (2004) Sequential changes of parathyroid hormone related protein (PTHrP) in articular cartilage during progression of inflammatory and degenerative arthritis. Ann Rheum Dis 63:917-922
33. Klooster AR, Bernier SM (2005) Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte. Arthritis Res Ther 7:R127-R138