Hydra, a model system for environmental studies

International Journal of Developmental Biology

Volumn 56, Issue 6-8, 2012, Pages 613-625

  Quinn, Brian ^a,b   Gagné, François ^c   Blaise, Christian ^c  

^a Atlantic Technological University Sligo   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c ENVIRONMENT CANADA   (Canada)

Author keywords

Bioassay; Hydra; Metal; Regeneration; Toxicity

Indexed keywords

AMLODIPINE; CARBAMAZEPINE; DIAZEPAM; DIGOXIN; ENDOCRINE DISRUPTOR; GEMFIBROZIL; IBUPROFEN; METAL; NANOMATERIAL; NAPROXEN; TOXIN;

AQUATIC ENVIRONMENT; ARTICLE; ASEXUAL REPRODUCTION; BIOASSAY; BIOLOGICAL MODEL; EFFLUENT; ENVIRONMENTAL IMPACT ASSESSMENT; ENVIRONMENTAL MONITORING; FEEDING BEHAVIOR; FRESHWATER ENVIRONMENT; HYDRA; INDICATOR ORGANISM; MORPHOLOGY; NONHUMAN; OXIDATIVE STRESS; POLLUTANT; PRIORITY JOURNAL; REGENERATION; REPRODUCTION; STEM CELL; TERATOGENESIS; TOXICITY; TOXICITY TESTING; TOXICOLOGY; XENOBIOTIC METABOLISM;

ANIMALS; CNIDARIAN VENOMS; ECOSYSTEM; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; HYDRA; PHARMACEUTICAL PREPARATIONS; REGENERATION; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL;

ANIMALIA; HYDRA;

EID: 84864491416     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.113469bq     Document Type: Article

References (140)

1. ADAMS, J. A. and HAILESELASSIE, H. M. (1984). The effects of polychlorinated biphenyls (Aroclors 1016 and 1254) on mortality, reproduction, and regeneration in Hydra oligactis. Arch Environ Contam Toxicol 13: 493-9.
2. ANDERSEN, R. A., WIGER, R., DAAE, H. L. and ERIKSEN, K. D. H. (1988). Is the metal binding protein metallothionein present in the coelenterate Hydra attenuata? Comp Biochem Physiol C 91: 553-557.
3. ARKHIPCHUK, V. V., BLAISE, C. and MALINOVSKAYA, M. V. (2006a). Use of Hydra for chronic toxicity assessment of waters intended for human consumption. Environ Pollut 142: 200-11.
4. ARKHIPCHUK, V. V., BLAISE, C. and MALINOVSKAYA, M. V. (2006b). Use of Hydra for chronic toxicity assessment of waters intended for human consumption. Environ Pollut 142: 200-211.
5. ARKHIPCHUK, V. V. and GARANKO, N. N. (2002). A novel nucleolar biomarker in plant and animal cells for assessment of substance cytotoxicity. Environ Toxicol 17: 187-94.
6. ARKHIPCHUK, V. V., GONCHARUK, V. V., CHERNYKH, V. P., MALOSHTAN, L. N. and GRITSENKO, I. S. (2004). Use of a complex approach for assessment of metamizole sodium and acetylsalicylic acid toxicity, genotoxicity and cytotoxicity. J Appl Toxicol 24: 401-7.
7. ARKHIPCHUK, V. V. and MALINOVSKAYA, M. V. (2002). Quality of water types in Ukraine evaluated by WaterTox bioassays. Environ Toxicol 17: 250-257.
8. BEACH, M. J. and PASCOE, D. (1998). The role of Hydra vulgaris (Pallas) in assessing the toxicity of freshwater pollutants. Water Res 32: 101-106.
9. BELLIS, S. L., KASS-SIMON, G. and RHOADS, D. E. (1992). Partial characterization and detergent solubilization of the putative glutathione chemoreceptor from Hydra. Biochemistry 31: 9838-9843.
10. BENSON, B. and BOUSH, G. M. (1983). Effect of pesticides and PCBs on budding rates of green Hydra. Bull. Environ Contam Toxicol 30: 344-350.
11. BERGMANN, A.S.H. (2010). Apoptosis, stem cells, and tissue regeneration. Science Signal 3: 8.
12. BLAISE, C., GAGNE, F., EULLAFFROY, P. and FERARD, J. F. (2006). Ecotoxicity of selected phamraceuticals of urban origin discharged tothe Saint-Lawrance river (Quebec, Canada): A review. Brazil J Aquat Sci Technol 10: 29-51.
13. BLAISE, C., GAGNE, F., FERARD, J. F. and EULLAFFROY, P. (2008). Ecotoxicity of selected nano-materials to aquatic organisms. Environ Toxicol 23: 591-8.
14. BLAISE, C. and KUSUI, T. (1997). Acute toxicity assessment of industrial effluents with a microplate-based Hydra attenuata assay. Environ Toxicol Water Qual 12: 53-60.
15. BRIEN, P. (1953). La pérennité somatique. Biol Rev 28: 308-349.
16. BODE, H. R. (2003). Head regeneration in Hydra. Dev Dynam 226: 225-236.
17. BOSCH, T. C. G. (2009). Hydra and the evolution of stem cells. BioEssays 31: 478-486.
18. BOSSERT, P., and GALLIOT, B. (2012). How to use Hydra as a model system to teach biology in a classroom? Int J Dev Biol 56: 637-652.
19. BÖTTGER, A. and ALEXANDROVA, O. (2007). Programmed cell death in Hydra. Semin Cancer Biol 17: 134-146.
20. BÖTTGER, A. and HASSEL, M. (2012). Hydra, a model system to trace the emergence of boundaries in eumetazoans. Int J Dev Biol 56: 583-591.
21. BOWDEN, H. C., WILBY, O. K., BOTHAM, C. A., ADAM, P. J. and ROSS, F. W. (1995). Assessment of the toxic and potential teratogenic effects of four glycol ethers and two derivatives using the Hydra regeneration assay and rat whole embryo culture. Toxicol In vitro 9: 773-781.
22. BRENNECKE, T., GELLNER, K. and BOSCH, T. C. G. (1998). The lack of a stress response in Hydra oligactis is due to reduced hsp70 mRNA stability. Eur J Biochem 255: 703-709.
23. BROWNE, C. L. and DAVIS, L. E. (1977). Cellular mechanisms of stimulation of bud production in Hydra by low levels of inorganic lead compounds. Cell Tissue Res 177: 555-570.
24. BRUN, G. L., BERNIER, M., LOSIER, R., DOE, K., JACKMAN, P. and LEE, H. B. (2006). Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity. Environ Toxicol Chem, 25: 2163-2176.
25. CAMPBELL, R. D. (1989). Taxonomy of the European Hydra (Gnidaria: Hydrozoa): a re-examination of its history with emphasis on the species H. vulgaris Pallas, H. attenuata Pallas and H. circumcincta Schulze. Zool J Linnean Soc 95: 219-244.
26. CARDENAS, M., FABILA, Y. V., YUM, S., CERBON, J., BÖHMER, F. D., WETZKER, R., FUJISAWA, T., BOSCH, T. C. G. and SALGADO, L. M. (2000). Selective protein kinase inhibitors block head-specific differentiation in Hydra. Cell Signal 12: 649-658.
27. CASTILLO, L. E., MARTINEZ, E., RUEPERT, C., SAVAGE, C., GILEK, M., PINNOCK, M. and SOLIS, E. (2006). Water quality and macroinvertebrate community response following pesticide applications in a banana plantation, Limon, Costa Rica. Sci Total Environ 367: 418-32.
28. CLARKE, S. M. and BARRICK, C. W. (1990). A bioassessment battery for use in an industrial setting: a new management approach. Environ Toxicol water 10: 81-90.
29. CUKER, B. E. and MOZLEY, S. C. (1981). Summer population fluctuations, feeding and growth of Hydra in an arctic lake. Limnol Oceanogr 26: 697-708.
30. DAM, R. V., HOGAN, A., HARFORD, A. and MARKICH, S. (2008). Toxicity and metal speciation characterisation of waste water from an abandoned gold mine in tropical northern Australia. Chemosphere 73: 305-313.
31. DASH, B., METZ, R., HUEBNER, H. J., PORTER, W. and PHILLIPS, T. D. (2006). Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris. Gene 381: 1-12.
32. DASH, B., METZ, R., HUEBNER, H. J., PORTER, W. and PHILLIPS, T. D. (2007). Molecular characterization of two superoxide dismutases from Hydra vulgaris. Gene 387: 93-108.
33. DELLAMATRICE, P., MONTEIRO, R., KAMIDA, H., NOGUEIRA, N., ROSSI, M. and BLAISE, C. (2005). Decolourization of Municipal Effluent and Sludge by Pleurotus sajor-caju and Pleurotus ostreatus. World J Microbiol Biotechnol 21: 1363-1369.
34. DIAZ-BAEZ, M. C., SÁNCHEZ, W. A., DUTKA, B. J., RONCO, A., CASTILLO, G., PICA-GRANADOS, Y., CASTILLO, L. E., RIDAL, J., ARKHIPCHUK, V. and SRIVASTAVA, R. C. (2002). Overview of results from the WaterTox intercalibration and environmental testing phase II program: Part 2, ecotoxicological evaluation of drinking water supplies. Environ Toxicol 17: 241-249.
35. DUTKA, B. J. (1989). Short term root elongation toxicity assay. In: DUTKA, B. J. (ed.) Methods for toxicological analysis of waters, wastewaters and sediments. Burlington, Ontario, Canada: Environment Canada, National Water Research Institute.
36. ELLIOTT, J. K., ELLIOTT, J. M. and LEGGETT, W. C. (1997). Predation by Hydra on larval fish: field and laboratory experiments with Bluegill (Lepomis macrochirus). Limnol Oceanog 42: 1416-1423.
37. FENT, K., WESTON, A. A. and CAMINADA, D. (2006). Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76: 122-159.
38. FERREIRA, L. F., AGUIAR, M. M., MESSIAS, T. G., POMPEU, G. B., LOPEZ, A. M., SILVA, D. P. and MONTEIRO, R. T. (2011). Evaluation of sugar-cane vinasse treated with Pleurotus sajor-caju utilizing aquatic organisms as toxicological indicators. Ecotoxicol Environ Saf 74: 132-7.
39. FU, L.-J., STAPLES, R. E. and STAHL, R. G. (1994). Assessing acute toxicities of pre-and post-treatment industrial wastewaters with Hydra attenuata: A comparative study of acute toxicity with the fathead minnow, Pimephales promelas. Environ Toxicol Chem 13: 563-569.
40. FU, L. J., STAPLES, R. E. and STAHL, R. G., JR. (1991). Application of the Hydra attenuata assay for identifying developmental hazards among natural waters and wastewaters. Ecotoxicol Environ Saf 22: 309-19.
41. FUKUHORI, N., KITANO, M. and KIMURA, H. (2005). Toxic effects of bisphenol A on sexual and asexual reproduction in Hydra oligactis. Arch Environ Contam Toxicol 48: 495-500.
42. GALLIOT, B., MILJKOVIC-LICINA, M., DE ROSA, R. and CHERA, S. (2006). Hydra, a niche for cell and developmental plasticity. Semin Cell Dev Biol 17: 492-502.
43. GELLNER, K., PRAETZEL, G. and BOSCH, T. C. G. (1992). Cloning and expression of a heat-inducible hsp70 gene in two species of Hydra which differ in their stress response. Eur J Biochem 210: 683-691.
44. GIERER, A., BERKING, S., BODE, H., DAVID, C.N., FLICK, K., HANSMANN, G., SCHALLER, H. and TRENKNER, E. (1972). Regeneration of hydra from reaggregated cells. Nat New Biol 239: 98-101.
45. HABETHA, M., ANTON-ERXLEBEN, F., NEUMANN, K. and BOSCH, T. C. G. (2003). The Hydra viridis / Chlorella symbiosis. Growth and sexual differentiation in polyps without symbionts. Zoology 106: 101-108.
46. HALBACH, U. (1984). Population dynamics of rotifers and its consequences for ecotoxicology. Hydrobiologia 109: 79-96.
47. HEMMRICH, G., ANOKHIN, B., ZACHARIAS, H. and BOSCH, T. C. G. (2007). Molecular phylogenetics in Hydra, a classical model in evolutionary developmental biology. Mol Phylogenet Evol 44: 281-290.
48. HERRICKS, E. E. and CAIRNS, J. (1982). Biological monitoring: Part III--Receiving system methodology based on community structure. Water Res 16: 141-153.
49. HERRING, C., ADAMS, J., POLLARD, S. and WILSON, B. (1987). Dose response studies using ethylene dibromide in Hydra oligactis. Bull Environ Contam Toxicol 40: 35-40.
50. HOARAU, P., GARELLO, G., GNASSIA-BARELLI, M., ROMÉO, M. and GIRARD, J.-P. (2004). Effect of three xenobiotic compounds on Glutathione S-Transferase in the clam Ruditapes decussatus. Aquat Toxicol 68: 87-94.
51. HOFFMEISTER-ULLERICH, S. (2007). Hydra-ancient model with modern outfit. Cellular and Mol Life Sci 64: 3012-3016.
52. HOLDWAY, D. A. (2005). Hydra population reproduction toxicity test method. In: BLAISE, C. & FÉRARD, J. (eds.) Small-Scale Freshwater Toxicity Investigations. Netherlands: Springer.
53. HOLDWAY, D. A., LOK, K. and SEMAAN, M. (2001). The acute and chronic toxicity of cadmium and zinc to two Hydra species. Environ Toxicol 16: 557-565.
54. HOLSTEIN, T. W., HOBMAYER, E. and TECHNAU, U. (2003). Cnidarians: An evolutionarily conserved model system for regeneration? Dev Dynam, 226: 257-267.
55. HYNE, R. V., RIPPON, G. D. and ELLENDER, G. (1992b). pH-Dependent uranium toxicity to freshwater Hydra. Sci Total Environ 125: 159-173.
56. HYNE, R. V., RIPPON, G. D., HUNT, S. M. and BROWN, G. H. (1996). Proceedures for the biological toxicity testing of mine waste waters using freshwater organisms Supervising Scientist Report. Darwin, NT.: Environmental Research Insitute of the Supervising Scientist.
57. HYNE, R. V., RIPPON, G. D., WHITE, J. and ELLENDER, G. (1992a). Accumulation of uranium by freshwater Hydra into discharged nematocysts. Aquat Toxicol 23: 231-245.
58. JOHNSON, E. M. (1980). A subvertebrate system for rapid determination of potential teratogenic hazards. J Environ Pathol Toxicol 4: 153-156.
59. JOHNSON, E. M., GABEL, B. E., CHRISTIAN, M. S. and SICA, E. (1986). The developmental toxicity of xylene and xylene isomers in the Hydra assay. Toxicol Appl Pharmacol 82: 323-328.
60. JOHNSON, E. M., GORMAN, R. M., GABEL, B. E. and GEORGE, M. E. (1982). The Hydra attenuata system for detection of teratogenic hazards. Teratog Carcinog Mutagen 2: 263-276.
61. JUCHELKA, C. M. and SNELL, T. W. (1994). Rapid toxicity assessment using rotifer ingestion rate. Arch Environ Contam Toxicol 26: 549-554.
62. KALAFATIC, M., ZNIDARIC, D., LUI, A. and WRISCHER, M. (1991). Effect of insecticides (Dimiline WP 25, Torak EC 24 and Gamacide 20) on Hydra (Hydra vulgaris Pallas). Int J Dev Biol 35: 335-340.
63. KARNTANUT, W. and PASCOE, D. (2000). A comparison of methods for measuring acute toxicity to Hydra vulgaris. Chemosphere 41: 1543-1548.
64. KARNTANUT, W. and PASCOE, D. (2002). The toxicity of copper, cadmium and zinc to four different Hydra (Cnidaria: Hydrozoa). Chemosphere 47: 1059-1064.
65. KARNTANUT, W. and PASCOE, D. (2005). Effects of removing symbiotic green algae on the response of Hydra viridissima (Pallas 1776) to metals. Ecotoxicol Environ Saf 60: 301-5.
66. KARNTANUT, W. and PASCOE, D. (2007). A comparison of metal accumulation by the cnidarian Hydra vulgaris directly from water or through contaminated prey and effects upon reproduction and regeneration. Songklanakarin J Sci Technol 29: 869-880.
67. KASS-SIMON, G. and PIEROBON, P. (2007). Cnidarian chemical neurotransmission, an updated overview. Comp Biochem Physiol A Mol Integr Physiol 146: 9-25.
68. KOOIJMAN, S. A. L. M. and METZ, J. A. J. (1984). On the dynamics of chemically stressed populations: The deduction of population consequences from effects on individuals. Ecotox Environ Saf 8: 254-274.
69. KOVAČEVIĆ, G., ŽELJEŽIĆ, D., HORVATIN, K. and KALAFATIĆ, M. (2007). Morphological features and comet assay of green and brown Hydra treated with aluminium. Symbiosis 44: 145-152.
70. KOVACEVIC, G. (2012). Value of the Hydra model system for studying symbiosis. Int J Dev Biol 56: 627-635.
71. LASKER, H. R., SYRON, J. A. and CLAYTON, W. S. (1982). The feeding response of Hydra verdis: Effects of prey density on capture rates. Biol Bull 162: 290-298.
72. LEHHOFF, H. M. (1961). Activation of the feeding reflex in Hydra littoralis. In: LENHOFF, H. M. & LOOMIS, W. F. (eds.) The biology of Hydra. University of Miami Press, FL.
73. LENHOFF, H. M. (1983). Hydra Research Methods., New York, Plenum Press.
74. LENHOFF, H. M. and BROWN, R. D. (1970). Mass Culture of Hydra: An Improved Method and Its Application to Other Aquatic Invertebrates. Lab Animal 4: 139-154.
75. LINK, J. and KEEN, R. (1995). Prey of Deep-water Hydra in Lake Superior. J Great Lake Res 21: 319-323.
76. LITTLEFIELD, C. L., FINKEMEIER, C. and BODE, H. R. (1991). Spermatogenesis in Hydra oligactis: II. How temperature controls the reciprocity of sexual and asexual reproduction. Dev Biol 146: 292-300.
77. LOMNICKI, A. and SLOBODKIN, L.B. (1966). Floating in Hydra littoralis. Ecology 47: 881-889.
78. LOOMIS, W. F. (1953). The Cultivation of Hydra Under Controlled Conditions. Science 117: 565-566.
79. LOOMIS, W. F. andLENHOFF, H. M. (1956). Growth and sexual differentiation of Hydra in mass culture. J Exp Zool 132: 555-568.
80. LUE, K. Y. and DE LA CRUZ, A. A. (1978). Mirex incorporation in the Environment: Toxicity in Hydra. Bull Environ Contam Toxicol 19: 412-416.
81. LUM, K. T., HUEBNER, H. J., LI, Y., PHILLIPS, T. D. and RAUSHEL, F. M. (2003). Organophosphate nerve agent toxicity in Hydra attenuata. Chem Res Toxicol 16: 953-957.
82. MALVINDI, M. A., CARBONE, L., QUARTA, A., TINO, A., MANNA, L., PELLEGRINO, T. and TORTIGLIONE, C. (2008). Rod-Shaped Nanocrystals Elicit Neuronal Activity In Vivo. Small, 4: 1747-1755.
83. MARROQUIN-CARDONA, A., DENG, Y., TAYLOR, J. F., HALLMARK, C. T., JOHNSON, N. M. and PHILLIPS, T. D. (2009). In vitro and in vivo characterization of mycotoxin-binding additives used for animal feeds in Mexico. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 26: 733-43.
84. MARTIN, V.J., LITTLEFIELD, C.L., ARCHER, W.E. and BODE, H.R. (1997). Embryogenesis in Hydra. Biol Bull 192: 345-363.
85. MAYURA, K., SMITH, E. E., CLEMENT, B. A. and PHILLIPS, T. D. (1991). Evaluation of the developmental toxicity of chlorinated phenols utilizing Hydra attenuata and postimplantation rat embryos in culture. Toxicol Appl Pharmacol 108: 253-66.
86. MITCHELL, F. M. and HOLDWAY, D. A. (2000). The acute and chronic toxicity of the dispersants Corexit 9527 and 9500, water accommodated fraction (WAF) of crude oil, and dispersant enhanced WAF (DEWAF) to Hydra viridissima (green hydra). Water Res 34: 343-348.
87. MÜLLER, W. A. (1996). Pattern formation in the immortal Hydra. Trends Genet 12: 91-96.
88. MUSCATINE, L. and LENHOFF, H. M. (1965). Symbiosis of Hydra and algae.I. Effects of some environmental cations on growth of symbiotic and aposymbiotic Hydra. Bio Bull 128: 415-424.
89. NODA, K. (1971). Reconstitution of dissociated cells of hydra. Zool Mag 80: 99-101.
90. OBERHOLSTER, P. J., BOTHA, A. M. and CLOETE, T. E. (2008). Biological and chemical evaluation of sewage water pollution in the Rietvlei nature reserve wetland area, South Africa. Env Poll 156: 184-192.
91. OSTROUMOVA, T. V. and MARKOVA, L. N. (2002). The Effects of Dopamine Synthesis Inhibitors and Dopamine Antagonists on Regeneration in the Hydra Attenuata. Neurosci Behav Physiol 32: 293-298.
92. OTTO, J.J., CAMPBELL, R.D. (1977). Tissue economics of hydra: regulation of cell cycle, animal size and development by controlled feeding rates. J Cell Sci 28: 117-132.
93. PACHURA-BOUCHET, S., BLAISE, C. and VASSEUR, P. (2006). Toxicity of nonylphenol on the cnidarian Hydra attenuata and environmental risk assessment. Environ Toxicol 21: 388-394.
94. PACHURA, S., CAMBON, J.-P., BLAISE, C. and VASSEUR, P. (2005). 4-Nonylphenol-induced toxicity and apoptosis in Hydra attenuate. Environ Toxicol Chem 24: 3085-3091.
95. PARDOS, M., BENNINGHOFF, C., GUÉGUEN, C., THOMAS, R., DOBROWOLSKI, J. and DOMINIK, J. (1999). Acute toxicity assessment of Polish (waste)water with a microplate-based Hydra attenuata assay: a comparison with the Microtox® test. Sci Total Environ 243-244: 141-148.
96. PASCOE, D., CARROLL, K., KARNTANUT, W. and WATTS, M. M. (2002). Toxicity of 17alpha-ethinylestradiol and bisphenol A to the freshwater Cnidarian Hydra vulgaris. Arch Environ Contam Toxicol 43: 56-63.
97. PASCOE, D., KARNTANUT, W. and MULLER, C. T. (2003). Do pharmaceuticals affect freshwater invertebrates? A study with the cnidarian Hydra vulgaris. Chemosphere 51: 521-528.
98. PIEROBON, P. (2012). Coordinated modulation of cellular signaling through ligand-gated ion channels in Hydra vulgaris (Cnidaria, Hydrozoa). Int J Dev Biol 56: 551-565.
99. POLLINO, C. A. and HOLDWAY, D. A. (1999). Potential of Two Hydra Species as Standard Toxicity Test Animals. Ecotox Environ Saf 43: 309-316.
100. QUINN, B., GAGNE, F. and BLAISE, C. (2007). Validation of a multi-well plate toxicity test to assess feeding behaviour of the cnidarian, Hydra attenuata. Fresen Environ Bull 16: 1100-1107.
101. QUINN, B., GAGNE, F. and BLAISE, C. (2008a). An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata. Sci Total Environ 389: 306-314.
102. QUINN, B., GAGNE, F. and BLAISE, C. (2008b). The effects of pharmaceuticals on the regeneration of the cnidarian, Hydra attenuata. Sci Total Environ 402: 62-69.
103. QUINN, B., GAGNE, F. and BLAISE, C. (2009). Evaluation of the acute, chronic and teratogenic effects of a mixture of eleven pharmaceuticals on the cnidarian, Hydra attenuata. Sci Total Environ 407: 1072-1079.
104. QUINN, B., GAGNÉ, F. and BLAISE, C. (2004). Oxidative metabolism activity in Hydra attenuata exposed to carbamazepine. Fresen Environ Bull 13: 783-788.
105. RENTZSCH, F., HOBMAYER, B. and HOLSTEIN, T. W. (2005). Glycogen synthase kinase 3 has a proapoptotic function in Hydra gametogenesis. Dev Biol 278: 1-12.
106. RIETHMULLER, N., CAMILLERI, C., FRANKLIN, N., HOGAN, A. C., KING, A., KOCH, A., MARKICH, S. J., TURLEY, C. and DAM, R. V. (2003). Ecotoxicological testing protocols for Australian tropical freshwater ecosystems. Supervising Scientist Report. Darwin, NT: Environmental Research Insitute of the Supervising Scientist.
107. RIETHMULLER, N., MARKICH, S. J., VAN DAM, R. A. and PARRY, D. (2001). Effects of water hardness and alkalinity on the toxicity of uranium to a tropical freshwater hydra (Hydra viridissima). Biomarkers 6: 45-51.
108. RIBI, G., TARDENT, R., TARDENT, P. and SCASCIGHINI, P. (1985). Dynamics of hydra populations in Lake Zurich, Switzerland, and Lake Maggiore, Italy. Swiss J Hydrol 47: 45-56.
109. RONCO, A., GAGNON, P., DIAZ-BAEZ, M. C., ARKHIPCHUK, V., CASTILLO, G., CASTILLO, L. E., DUTKA, B. J., PICA-GRANADOS, Y., RIDAL, J., SRIVASTAVA, R. C. and SANCHEZ, A. (2002a). Overview of results from the WaterTox intercalibration and environmental testing phase II program: Part 1, statistical analysis of blind sample testing. Environ Toxicol 17: 232-40.
110. RONCO, A., GAGNON, P., DIAZ-BAEZ, M. C., ARKHIPCHUK, V., CASTILLO, G., CASTILLO, L. E., DUTKA, B. J., PICA-GRANADOS, Y., RIDAL, J., SRIVASTAVA, R. C. and SÁNCHEZ, A. (2002b). Overview of results from the WaterTox intercalibration and environmental testing phase II program: Part 1, statistical analysis of blind sample testing. EnvironToxicol 17: 232-240.
111. ROSENKRANTZ, R. T., POLLINO, C. A., NUGEGODA, D. and BAUN, A. (2008). Toxicity of water and sediment from stormwater retarding basins to Hydra hexactinella. Environ Pollut 156: 922-7.
112. SAKAGUCHI, M., MIZUSINA, A. and KOBAYAKAWA, Y. (1996). Structure, development, and maintenance of the nerve net of the body column in Hydra. J Comp Neurol 373: 41-54.
113. SARRAS, M. P. J. (2012). Components, structure, biogenesis and function of the Hydra extracellular matrix in regeneration, pattern formation and cell differentiation. Int J Dev Biol 56: 567-576.
114. SANTIAGO-FANDIÑO, V. J. R. (1983). The effects of nickel and cadmium on the growth rate of Hydra littoralis and an assessment of the rate of uptake of 63Ni and 14C by the same organism. Water Res 17: 917-923.
115. SCHAIBLE, R., RINGELHAN, F., KRAMER, B. H. and MIETHE, T. (2011). Environmental challenges improve resource utilization for asexual reproduction and maintenance in Hydra. Exp Gerontol 46: 794-802.
116. SCHWARTZ, S. S., HANN, B. J. and HEBERT, P. D. N. (1983). The feeding ecology of Hydra and possible implications in the structuring of pond zooplankton communities. Biol Bull 164: 136-142.
117. SCHWARTZ, S. S. and HEBERT, P. D. N. (1989). The Effect of Hydra on the Outcome of Competition Between Daphnia and Simocephalus. Biol Bull 176: 147-154.
118. SEGNER, H., CAROLL, K., FENSKE, M., JANSSEN, C. R., MAACK, G., PASCOE, D., SCHAFERS, C., VANDENBERGH, G. F., WATTS, M. and WENZEL, A. (2003). Identification of endocrine-disrupting effects in aquatic vertebrates and invertebrates: report from the European IDEA project. Ecotoxicol Environ Saf 54: 302-14.
119. SLOBODKIN, L. B. & BOSSERT, P. E. (2001). Cnidaria. In: JAMES, H. T. & ALAN, P. C. (eds.) Ecology and Classification of North American Freshwater Invertebrates (Second Edition). San Diego: Academic Press.
120. SLOOFF, W., CANTON, J. H. & HERMENS, J. L. M. (1983). Comparison of the susceptibility of 22 freshwater species to 15 chemical compounds. I. (Sub)acute toxicity tests. AquatToxicol 4: 113-128.
121. STEBBING, A. R. D. and POMROY, A. J. (1978). A sublethal technique for assessing the effects of contaminants using Hydra littoralis. Water Res 12: 631-635.
122. STEELE, R. E. (2002). Developmental Signaling in Hydra: What Does It Take to Build a "Simple" Animal? Dev Biol 248: 199-219.
123. STENERSEN, J., KOBRO, S., BJERKE, M. and AREND, U. (1987). Glutathione transferases in aquatic and terrestrial animals from nine phyla. Comp Biochem Physio C Comp Pharmacol 86: 73-82.
124. TAKAHASHI, T. and HAMAUE, N. (2010). Molecular characterization of Hydra acetylcholinesterase and its catalytic activity. FEBS Letters 584: 511-516.
125. TARRANT, A. M. (2005). Endocrine-like signaling in cnidarians: Current understanding and implications for ecophysiology. Int Comp Biology 45: 201-214.
126. TAYLOR, E. J., MORRISON, J. E., BLOCKWELL, S. J., TARR, A. and PASCOE, D. (1995). Effects of lindane on the predator-prey interaction between Hydra oligactis (Pallas) and Daphnia magna (Strauss). Arch Environ Con Tox 29: 291-296.
127. TEN BRINK, B. J. E. and WOUDSTRA, J. H. (1991). Towards an effective and rational water management: the aquatic outlook project-integrating water management, monitoring and research. Eur Water Pollut Control 1: 20-27.
128. TERNES, T. A. (1998). Occurrence of drugs in German sewage treatment plants and rivers. Water Res 32: 3245-3260.
129. TORTIGLIONE, C., QUARTA, A., MALVINDI, M. A., TINO, A. and PELLEGRINO, T. (2009). Fluorescent Nanocrystals Reveal Regulated Portals of Entry into and Between the Cells of Hydra. PLoS ONE 4: e7698.
130. TROTTIER, S., BLAISE, C., KUSUI, T. and JOHNSON, E. M. (1997). Acute toxicity assessment of aqueous samples using a microplate-based Hydra attenuata assay. Environ Toxicol Water Qual 12: 265-271.
131. VAN DAM, R. A., HOGAN, A. C., MCCULLOUGH, C. D., HOUSTON, M. A., HUMPHREY, C. L. and HARFORD, A. J. (2010). Aquatic toxicity of magnesium sulfate, and the influence of calcium, in very low ionic concentration water. Environ Toxicol Chem 29: 410-421.
132. VERNOUILLET, G., EULLAFFROY, P., LAJEUNESSE, A., BLAISE, C., GAGNE, F. and JUNEAU, P. (2010). Toxic effects and bioaccumulation of carbamazepine evaluated by biomarkers measured in organisms of different trophic levels. Chemosphere 80: 1062-1068.
133. VIGANÒ, L., BASSI, A. and GARINO, A. (1996). Toxicity Evaluation of Waters from a Tributary of the River Po Using the 7-Day Ceriodaphnia dubia Test. Ecotox Environ Safe 35: 199-208.
134. WALKER, C. H., HOPKIN, S. P., SIBLY, R. M. and PEAKALL, D. B. (2006). Principles of Ecotoxicology Boca Raton, Florida, USA, Taylor Francis.
135. WALSH, E. J. (1995). Habitat-specific predation susceptibilities of a littoral rotifer to two invertebrate predators. Hydrobiologia 313-314: 205-211.
136. WILBY, O. K. (1988). The Hydra regeneration assay. Proceedings of Workshop organised by Association Francaise de Teratologie: 108-124.
137. WILBY, O. K. and TESH, J. M. (1990). The Hydra assay as an early screen for teratogenic potential. Toxicol in vitro 4: 582-583.
138. YANG, Y. G., MAYURA, K., SPAINHOUR, C. B., JR., EDWARDS, J. F. and PHILLIPS, T. D. (1993). Evaluation of the developmental toxicity of citrinin using Hydra attenuata and postimplantation rat whole embryo culture. Toxicol 85: 179-98.
139. YEO, M.-K. and KANG, M. (2010). The effect of nano-scale Zn-doped TiO and pure TiO particles on Hydra magnipapillata. Mol Cell Toxicol 6: 9-17.
140. YOSHIDA, K., FUJISAWA, T., HWANG, J. S., IKEO, K. and GOJOBORI, T. (2006). Degeneration after sexual differentiation in Hydra and its relevance to the evolution of aging. Gene 385: 64-70.