Selective targeting of c-Abl via a cryptic mitochondrial targeting signal activated by cellular redox status in leukemic and breast cancer cells

Pharmaceutical Research

Volumn 29, Issue 8, 2012, Pages 2317-2328

  Constance, Jonathan E ^a   Despres, Samuel D ^a   Nishida, Akemi ^a   Lim, Carol S ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

C Abl; CRyptic MTS; Mitochondria; Reactive oxygen species; Translocation

Indexed keywords

7 AMINODACTINOMYCIN; ABELSON KINASE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; IMATINIB; PROTEIN BCL XL; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; SERINE; THREONINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL ASSAY; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TARGETING SIGNAL; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL DEATH; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; GENE EXPRESSION; HUMANS; LEUKEMIA; MAMMARY NEOPLASMS, ANIMAL; MICE; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-ABL; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS;

EID: 84864475028     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0758-9     Document Type: Article

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