Normal vaginal flora, disorders and application of probiotics in pregnancy

Archives of Gynecology and Obstetrics

Volumn 286, Issue 2, 2012, Pages 325-332

  Stojanović, Nemanja ^a   Plećaš, Darko ^b   Plešinac, Snežana ^b  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Abnormal vaginal microflora; Cervical competence; Lactobacillus rhamnosus BMX 54; Pregnancy; Probiotic treatment

Indexed keywords

NORMOGIN; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BETA HEMOLYTIC STREPTOCOCCUS; CANDIDA ALBICANS; CERVICAL LENGTH MEASUREMENT; CHEMOPROPHYLAXIS; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; DRUG EFFICACY; ENTEROCOCCUS; ESCHERICHIA COLI; FEMALE; FETUS; HUMAN; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; PH MEASUREMENT; PREGNANCY; PROSPECTIVE STUDY; PROTEUS MIRABILIS; RANDOMIZED CONTROLLED TRIAL; STAPHYLOCOCCUS; UTERINE CERVIX DILATATION; VAGINA DISCHARGE; VAGINA DISEASE; VAGINA FLORA;

ADMINISTRATION, INTRAVAGINAL; ADULT; CERVICAL LENGTH MEASUREMENT; FEMALE; HUMANS; LACTOBACILLUS RHAMNOSUS; PREGNANCY; PROBIOTICS; VAGINA; VAGINAL DISCHARGE; VAGINOSIS, BACTERIAL; YOUNG ADULT;

EID: 84864437652     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-012-2293-7     Document Type: Article

References (43)

1. Witkin SS, Linhares IM, Giraldo P (2007) Bacterial flora of the female genital tract: function and immune regulation. Best Pract Res Clin Obstet Gynecol 21:347-354
2. Fitzsimmons N, Berry DR (1994) Inhibition of Candida albicans by Lactobacillus acidophilus: evidence for the involvement of a peroxidase system. Microbios 80:125-133
3. Hawes SE, Hillier SL, Benedetti J, Stevens CE, Koutsky LA, Wolner-Hanssen P (1996) Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections. J Infect Dis 174(5):1058-1063
4. Wilks M, Wiggins R, Whiley A, Hennessy E, Warwick S, Porter H, Corfield A, Millar M (2004) Identification and H(2)O(2) production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with outcome. J Clin Microbiol 42:713-717
5. Sablon E, Contreras B, Vandamme E (2000) Antimicrobial peptides of lactic acid bacteria: mode of action, genetics and biosynthesis. Adv Biochem Eng Biotechnol 68:21-60
6. Li J, Aroutcheva AA, Faro S, Chikindas ML (2005) Mode of action of lactocin 160, a bacteriocin from vaginal Lactobacillus rhamnosus. Infect Dis Obstet Gynecol 13:135-140
7. Reid G, Tieszer C, Lam D (1995) Influence of lactobacilli on the adhesion of Staphylococcus aureus and Candida albicans to fibers and epithelial cells. J Ind Microbiol 15:248-253
8. Heinemann C, Hylckama Vlieg JE, Janssen DB, Busscher HJ, van der Mei HC, Reid G (2000) Purification and characterization of a surface-binding protein from Lactobacillus fermentum RC-14 that inhibits adhesion of Enterococcus faecalis 1131. FEMS Microbiol Lett 190:177-180
9. Aroutcheva AA, Simoes JA, Faro S (2001) Antimicrobial protein produced by vaginal Lactobacillus acidophilus that inhibits Gardnerella vaginalis. Infect Dis Obstet Gynecol 9:33-39
10. Schwebke JR, Richey CM, Weiss HL (1999) Correlation of behaviors with microbiological changes in vaginal flora. J Infect Dis 180:1632-1636
11. Koumans EH, Sternberg M, Bruce C, McQuillan G, Kendrick J, Sutton M et al (2007) The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Trans Dis 34(11):864-869
12. Koumans E, Lane S, Aubry R, DeMott K, Webster N, Levandowski B, Berman S, Markowitz L (2011) Evaluation of Syracuse Healthy Start's program for abnormal flora management to reduce preterm birth among pregnant women. Mat Child Health J 15:1020-1028
13. Riggs M, Klebanoff M, Nansel T, Zhang J, Schwebke J, Andrews W (2007) Longitudinal association between hormonal contraceptives and bacterial vaginosis in women of reproductive age. Sex Trans Dis 34:954-959
14. Denney JM, Culhane JF (2009) Bacterial vaginosis: a problematic infection from both a perinatal and neonatal perspective. Sem Fetal Neonatal Med 14:200-203
15. Donders GGG, Bellen G, Rozeberga D (2011) Aerobic vaginitis in pregnancy. BJOG: Int J Obstet Gynecol 118:1163-1170
16. Ehrström S, Daroczy K, Rylander E, Samuelsson C, Johannesson U, Anzén B, Påhlson C (2010) Lactic acid bacteria colonization and clinical outcome after probiotic supplementation in conventionally treated bacterial vaginosis and vulvovaginal candidiasis. Microb Infect 12:691-699
17. Marcone V, Rocca G, Lichtner M, Calzolari E (2010) Long-term vaginal administration of Lactobacillus rhamnosus as a complementary approach to management of bacterial vaginosis. Int J Gynecol Obstet 110:223-226
18. Rossi A, Rossi T, Bertini M, Caccia G (2010) The use of Lactobacillus rhamnosus in the therapy of bacterial vaginosis. Evaluation of clinical efficacy in a population of 40 women treated for 24-months. Arch Gynecol Obstet 281:1065-1069
19. Ya W, Reifer C, Miller LE (2010) Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study. Am J Obstet Gynecol 203:120
20. Donati L, Di Vico A, Nucci M, Quagliozzi L, Spagnuolo T, Labianca A, Bracaglia M, Ianniello F, Caruso A, Paradisi G (2010) Vaginal microbial flora and outcome of pregnancy. Arch Gynecol Obstet 281(4):589-600
21. Klebanoff MA, Hauth JC, MacPherson CA, Carey JC, Heine RP, Wapner RJ et al (2004) Time course of the regression of asymptomatic bacterial vaginosis in pregnancy with and without treatment. Am J Obstet Gynecol 190(2):363-370
22. Hay PE, Lamont RF, Taylor-Robinson D, Morgan DJ, Ison C, Pearson J (1994) Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. Br Med J 308:295-298
23. Carey JC, Klebanoff MA (2005) Is a change in the vaginal flora associated with an increased risk of preterm birth? Am J Obstet Gynecol 192(4):1341-1346
24. Donders GG, Van Calsteren K, Bellen G, Reybrouck R, Van den Bosch T, Riphagen I, Van Lierde S (2009) Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. BJOG: Int J Obstet Gynecol 116:1315-1324
25. Leitich H, Kiss H (2007) Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol 21(3):375-390
26. Donders GG, Van Calsteren C, Bellen G, Reybrouck R, Van den Bosch T, Riphagen I, Van Lierde S (2010) Association between abnormal vaginal flora and cervical length as risk factors for preterm birth. Ultrasound Obstet Gynecol 2010 Jan 26 (epub ahead of print)
27. Mancuso MS, Figueroa D, Szychowski JM, Paden MM, Owen J (2011) Midtrimester bacterial vaginosis and cervical length in women at risk for preterm birth. Am J Obstet Gynecol 204:342
28. Usui R, Ohkuchi S, Matsubara S, Izumi A, Watanabe T, Suzuki M, Minakami H (2000) Vaginal lactobacilli and preterm birth. J Perinat Med 30:458-466
29. Hay PE (2004) Bacterial vaginosis and miscarriage. Curr Opin Infect Dis 17(1):41-44
30. Amsel R, Totten PA, Spegiel CA (1983) Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 74:14-22
31. Pararas MV, Skevaki CL, Kafetzis DA (2006) Preterm birth due to maternal infection: Causative pathogens and modes of prevention. Eur J Clin Microbiol Infect Dis 25(9):562-569
32. Simhan HN, Caritis SN, Krohn MA, Martinez de Teada B, Landers DV, Hillier SL (2003) Decreased cervical proinflammatory cytokines permit subsequent upper genital tract infection during pregnancy. Am J Obstet Gynecol 189:560-567
33. Waters TP, Denney JM, Mathew L, Goldenberg RL, Culhane JF (2008) Longitudinal trajectory of bacterial vaginosis during pregnancy. Am J Obstet Gynecol 199:431-435
34. Othman M, Alfirevic Z, Neilson JP (2007) Probiotics for preventing preterm labour. Cochrane Database of Systematic Reviews: Reviews 2007 Issue 1. Wiley, Chichester, doi:10.1002/14651858.CD005941.pub2
35. Larsson PG, Stray-Pedersen B, Ryttig K, Larsen S (2008) Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, doubleblind, randomized, placebo-controlled study. BMC Women's Health 8:3
36. Martinez RCR, Franceschini SA, Patta MC, Quintana SM, Gomes BC, De Martinis ECP, Reid G (2009) Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial. Can J Microbiol 55:133-138
37. Simmons LE, Rubens CE, Darmstadt GL, Gravett MG (2010) Preventing preterm birth and neonatal mortality: exploring the epidemiology, causes, and interventions. Semin Perinatol 34(6):408-415
38. Matijevic R, Grgic O, Knezevic M (2010) Vaginal pH versus cervical length in the midtrimester as screening predictors of preterm labor in a low-risk population. Int J Gynecol Obstet 111:41-44
39. Hoyme UB, Saling E (2004) Efficient prematurity prevention is possible by pH-self measurement and immediate therapy of threatening ascending infection. Eur J Obstet Gynecol Reprod Biol 115(2):148-153
40. Lamont RF, Taylor D (2010) The role of bacterial vaginosis, aerobic vaginitis, abnormal vaginal flora and the risk of preterm birth. BJOG 117(1):119-120
41. Hoyme UB, Huebner J (2010) Prevention of preterm birth is possible by vaginal pH screening, early diagnosis of bacterial vaginosis or abnormal vaginal flora and treatment. Gynecol Obstet Invest 70(4):286-290
42. Saling E (2011) Problems in prevention of preterm birth-regrettable contradictions. A special comment from the Founder of the Journal of Perinatal Medicine. J Perinat Med 39(3):223-225
43. Donders GGG, Vereecken A, Bosmans E, Dekeersmaecker A, Van Bulck B, Spitz B (2000) Pathogenesis of abnormal vaginal bacterial flora. Am J Obstet Gynecol 182:872-878