Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: A randomized, double-blind, placebo-controlled trial

Canadian Journal of Microbiology

Volumn 55, Issue 2, 2009, Pages 133-138

  Martinez, Rafael C R ^a   Franceschini, Silvio A ^a   Patta, Maristela C ^a   Quintana, Silvana M ^a   Gomes, Bruna C ^a   De Martinis, Elaine C P ^a   Reid, Gregor ^b,c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Bacterial vaginosis; Lactobacillus reuteri RC 14; Lactobacillus rhamnosus GR 1; Probiotic; Tinidazole

Indexed keywords

BACTERIAL VAGINOSIS; LACTOBACILLUS REUTERI RC-14; LACTOBACILLUS RHAMNOSUS GR-1; PROBIOTIC; TINIDAZOLE;

CURING;

BACTERIOLOGY;

PLACEBO; TINIDAZOLE;

ASSESSMENT METHOD; BACTERIAL DISEASE; BACTERIUM; DRUG; PROBIOTICS; REPRODUCTIVE DISORDER;

ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL STRAIN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; LACTOBACILLUS REUTERI; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINGLE DRUG DOSE; VAGINITIS;

ADOLESCENT; ADULT; BRAZIL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LACTOBACILLUS REUTERI; LACTOBACILLUS RHAMNOSUS; MIDDLE AGED; PLACEBOS; PROBIOTICS; TINIDAZOLE; TREATMENT OUTCOME; VAGINA; VAGINOSIS, BACTERIAL; YOUNG ADULT;

BACTERIA (MICROORGANISMS); LACTOBACILLUS REUTERI; LACTOBACILLUS RHAMNOSUS;

EID: 65349108053     PISSN: 00084166     EISSN: None     Source Type: Journal    
DOI: 10.1139/W08-102     Document Type: Article

References (35)

1. Allsworth, J.E., and Peipert, J.F. 2007. Prevalence of bacterial vaginosis: 2001-2004 National Health and Nutrition Examination Survey data. Obstet. Gynecol. 109(1): 114-120. PMID:17197596.
2. Amsel, R., Totten, P.A., Spiegel, C.A., Chen, K.C., Eschenbach, D., and Holmes, K.K. 1983. Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic associations. Am. J. Med. 74: 14-22. doi:10.1016/0002- 9343(83)91112-9. PMID:6600371.
3. Anukam, K., Osazuwa, E., Ahonkhai, I., Ngwu, M., Osemene, G., Bruce, A.W., and Reid, G. 2006a. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral pro - biotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 8: 1450-1454. doi:10.1016/j.micinf. 2006.01.003. PMID:16697231.
4. Anukam, K.C., Osazuwa, E., Osemene, G.I., Ehigiagbe, F., Bruce, A.W., and Reid, G. 2006b. Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. Microbes Infect. 8: 2772-2776. doi:10.1016/j.micinf.2006.08. 008. PMID:17045832.
5. Bagnoli, V.R. 1994. An overview of the clinical experience with secnidazole in bacterial vaginosis and trichomoniasis. Drug Invest. 8: 53-60.
6. Barrons, R., and Tassone, D. 2008. Use of Lactobacillus probiotics for bacterial genitourinary infections in women: a review. Clin. Ther. 30: 453-456. doi:10.1016/j.clinthera.2008.03.013. PMID:18405785.
7. Bradshaw, C.S., Morton, A.N., Hocking, J., Garland, S.M., Morris, M.B., Moss, L.M., et al. 2006a. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronida - zole therapy and factors associated with recurrence. J. Infect.Dis. 193: 1479-1486. doi:10.1086/503780. PMID:16652274.
8. Bradshaw, C.S., Tabrizi, S.N., Fairley, C.K., Morton, A.N., Rudland, E., and Garland, S.M. 2006b. The association of Atopobium vaginae and Gardnerella vaginalis with bacterial vaginosis and recurrence after oral metronidazole therapy. J. Infect. Dis. 194: 828-836. doi:10.1086/506621. PMID:16941351.
9. Burton, J.P., Devillard, E., Cadieux, P.A., Hammond, J.A., and Reid, G. 2004. Detection of Atopobium vaginae in postmeno - pausal women by cultivation-independent methods warrants further investigation. J. Clin. Microbiol. 42: 1829-1831. doi:10. 1128/JCM.42.4.1829-1831.2004. PMID:15071062.
10. Camargo, R.P., Simões, J.A., Cecatti, J.G., Alves, V.M., and Faro, S. 2005. Impact of treatment for bacterial vaginosis on prematurity among Brazilian pregnant women: a retrospective cohort study. Sao Paulo Med. J. 123: 108-112. doi:10.1590/S1516-31802005000300004. PMID:16021272.
11. Centers for Disease Control and Prevention (CDC). 2002. Sexually transmitted diseases treatment. Guidelines. MMWR recommendations and reports. Vol. 51. pp. 1-80. Available from http://www.cdc.gov/mmwr/preview/mmwrhtml/ rr5106a1.htm [accessed 18 October 2007].
12. Drago, L., De Vecchi, E., Nicola, L., Zucchetti, E., Gismondo, M.R., and Vicariotto, F. 2007. Activity of a Lactobacillus acid - ophilus-based douche for the treatment of bacterial vaginosis. J. Altern. Complement. Med. 13: 435-438. doi:10.1089/acm.2006. 6040. PMID:17532736.
13. Eriksson, K., Carlsson, B., Forsum, U., and Larrson, P.G. 2005. A double-blind treatment study of bacterial vaginosis with normal vaginal lactobacilli after an open treatment with vaginal clindamycin ovules. Acta Derm. Venereol. 85: 42-46. doi:10.1080/00015550410022249. PMID:15848990.
14. FAO/WHO. 2001. Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report. Available from ftp://ftp.faoorg/ docrep/fao/meeting/009/y6398e.pdf [accessed 31 January 2009.]
15. Hogan, V.K., Culhane, J.F., Hitti, J., Rauh, V.A., McCollum, K.F.,and Agnew, K.J. 2007. Relative performance of three methods for diagnosing bacterial vaginosis during pregnancy. Matern. Child Health J. 11: 532-539. doi:10.1007/s10995-007-0205-4. PMID:17874288.
16. Jokipii, A.M., Myllyä, V., Hokkanen, E., and Jokipii, L. 1977. Penetration of the blood brain barrier by metronidazole and tinida-zole. J. Antimicrob. Chemother. 3: 239-245. doi:10.1093/jac/3. 3.239. PMID:873873.
17. Karasz, A., and Anderson, M. 2003. The vaginitis monologues: women's experiences of vaginal complaints in a primary care setting. Soc. Sci. Med. 56: 1013-1021. doi:10.1016/S02779536(02)00092-8. PMID:12593874.
18. Klebanoff, M.A., Schwebke, J.R., Zhang, J., Nansel, T.R., Yu, K.F., and Andrews, W.W. 2004. Vulvovaginal symptoms in women with bacterial vaginosis. Obstet. Gynecol. 104: 267-272. PMID:15291998.
19. Larsson, P.G. 1995. Bacterial vaginosis treatment evaluation before one month is not accurate. Am. J. Obstet. Gynecol. 172: 16381639. doi:10.1016/0002-9378(95)90516-2. PMID:7755085.
20. Larsson, P.G., and Forsum, U. 2005. Bacterial vaginosis - a disturbed bacterial flora and treatment enigma. APMIS, 113: 305-316. doi:10.1111/j.1600-0463.2005.apm-113501.x. PMID:16011656.
21. Larsson, P.G., Stray-Pedersen, B., Ryttig, K.R., and Larsen, S. 2008. Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6 - month, double-blind, randomized, placebo-controlled study. BMC Womens Health, 8: 3. doi:10.1186/1472-6874- 8-3. PMID:18197974.
22. Laughton, J.M., Devillard, E., Heinrichs, D.E., Reid, G., and McCormick, J.K. 2006. Inhibition of expression of a staphylo - coccal superantigen-like protein by a soluble factor from Lactobacillus reuteri. Microbiology, 152: 1155-1167. doi:10.1099/ mic.0.28654-0. PMID:16549678.
23. Livengood, C.H., III, Ferris, D.G., Wiesenfeld, H.C., Hillier, S.L., Soper, D.E., Nyirjesy, P., et al. 2007. Effectiveness of two tini - dazole regimens in treatment of bacterial vaginosis: a randomized controlled trial. Obstet. Gynecol. 110: 302-309. PMID:17666604.
24. Marrazzo, J.M., Cook, R.L., Wiesenfeld, H.C., Murray, P.J., Busse, B., Krohn, M., and Hillier, S.L. 2006. Women's satisfaction with an intravaginal Lactobacillus capsule for the treatment of bacterial vaginosis. J. Womens Health (Larchmt), 15: 1053-1060. PMID:17125424.
25. McGregor, J.A., Lawellin, D., Franco-Buff, A., and Todd, J.K. 1991. Phospholipase C activity in microorganisms associated with reproductive tract infection. Am. J. Obstet. Gynecol. 164: 682-686. PMID:1992722.
26. 2 activity. Am. J. Obstet. Gynecol. 167: 1588-1594. PMID:1471671.
27. Morris, M., Nicoll, A., Simms, I., Wilson, J., and Catchpole, M. 2001. Bacterial vaginosis: a public health review. BJOG. 108: 439-450. doi:10.1016/S0306-5456(00)00124-8.
28. Myer, L., Kuhn, L., Denny, L., and Wright, T.C. 2006. Recurrence of symptomatic bacterial vaginosis in women over the course of a 12-month period after oral metronidazole therapy in HIV-positive and -negative women. J. Infect. Dis. 194: 1797-1799. doi:10.1086/509625.
29. Nailor, M.D., and Sobel, J.D. 2007. Tinidazole for bacterial vagi - nosis. Expert Rev. Anti Infect. Ther. 5: 343-348. doi:10.1586/14787210.5. 3.343. PMID:17547500.
30. Nugent, R.P., Khron, M.A., and Hillier, S.L. 1991. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J. Clin. Microbiol. 29: 297-301. PMID:1706728.
31. O'Brien, G., and Serwint, J.R. 2008. Bacterial vaginosis. Pediatr. Rev. 29: 209-211. doi:10.1542/pir.29-6-209. PMID:18515339.
32. Reid, G. 2001. Probiotic agents to protect the urogenital tract against infection. Am. J. Clin. Nutr. 73: 437-443.
33. Saunders, S., Bocking, A., Challis, J., and Reid, G. 2007. Effect of Lactobacillus on Gardnerella vaginalis biofilms. Colloids Surf. B Biointerfaces, 55: 138-142. doi:10.1016/j.colsurfb.2006.11. 040. PMID:17234391.
34. Velraeds, M.M., van der Mei, H.C., Reid, G., and Busscher, H.J. 1996. Inhibition of initial adhesion of uropathogenic Enterococ - cus faecalis by biosurfactants from Lactobacillus isolates. Appl. Environ. Microbiol. 62: 1958-1963. PMID:8787394.
35. Wilks, M., Wiggins, R., Whiley, A., Hennessy, E., Warwick, S., Porter, H., et al. 2004. Identification and H2O2 production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with outcome. J. Clin. Microbiol. 42: 713-717. doi:10.1128/JCM.42.2.713-717.2004. PMID:14766841.