Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 16, 2012, Pages 5208-5214

  Martínez González, Sonia ^a   Hernández, Ana Isabel ^a   Varela, Carmen ^a   Lorenzo, Milagros ^a   Ramos Lima, Francisco ^a   Cendón, Elena ^a   Cebrián, David ^a   Aguirre, Enara ^a   Gomez Casero, Elena ^a   Albarran M I ^a   Alfonso, Patricia ^a   García Serelde, Beatriz ^a   Mateos, Genoveva ^a   Oyarzabal, Julen ^a   Rabal, Obdulia ^a   Mulero, Francisca ^a   Gonzalez Granda, Teresa ^a   Link, Wolfgang ^a   Fominaya, Jesús ^a   Barbacid, Mariano ^a   Bischoff, James R ^a   Pizcueta, Pilar ^a   Blanco Aparicio, Carmen ^a   Pastor, Joaquín ^a   more..

^a Centro Nacional de Investigations Oncológicas   (Spain)

Author keywords

Cancer treatment; Imidazo 1,2 a pyrazines; PI3K inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; ETP 46992; K RAS PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG IDENTIFICATION; GENE MUTATION; IN VIVO STUDY; LUNG TUMOR; MOUSE; NONHUMAN; ONCOGENE; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR XENOGRAFT;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CYTOCHROMES; DISEASE MODELS, ANIMAL; HALF-LIFE; HUMANS; IMIDAZOLES; MICE; MICE, INBRED BALB C; MICROSOMES, LIVER; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PYRAZINES; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HETEROLOGOUS;

EID: 84864414528     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.093     Document Type: Article

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