Novel polycyclic 'cage'-1,2-diamines as potential anti-tuberculosis agents

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 1-9

  Onajole, Oluseye K ^a   Coovadia, Yacoob ^b   Kruger, Hendrik G ^a   Maguire, Glenn E M ^a   Pillay, Melendhran ^b   Govender, Thavendran ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b INKOSI ALBERT LUTHULI CENTRAL HOSPITAL   (South Africa)

Author keywords

Anti tuberculosis; Polycyclic "cage"; SQ109; Tuberculosis

Indexed keywords

11 HYDROXYLPENTACYCLO[5.4.0.0. 2,6 .0 3,10 .0 5,9]UNDECANE 8 AMINOETHYL(N 3,7 DIMETHYLOCTA 2,6 DIEN AMINE); 4 (N 3,7 DIMETHYLOCTA 2,6 DIENYL)ACETAMIDE 4 AZAHEXACYCLO[5.4.1.0. 2,6 .0 3,10 .0 5,9 .0 8,11]DODECAN 3 OL; 4 (N ETHYL 3,7 DIMETHYLOCTA 2,6 DIENYL)AMINE 4 AZAHEXACYCLO[5.4.1.0 .2,6 .0 3,10 .0 5,9 .0 8,11]DODECAN 3 OL; 8 (N 3,7 DIMETHYLOCTA 2,6 DIENYLAMINO)ACETAMIDE 8,11 OXAPENTACYCLO[5.4.0.0. 2,6 .0 3,10 .0 5,9]UNDECANE; 8,11 OXAPENTACYCLO[5.4.0.0. 2,6 .0 3,10 .0 5,9]UNDECANE 8 AMINOETHYL(N 3,7 DIMETHYLOCTA 2,6 DIEN AMINE); AZA PENTACYCLOUNDECANE; N (2 ADAMANTYL) N' GERANYLETHYLENEDIAMINE; N GERANYL N' (11 TRISHOMOCUBANYL)ETHANE 1,2 DIAMINE; N GERANYL N' (8 PENTACYCLOUNDECYL)ETHANE 1,2 DIAMINE; OXA PENTACYCLOUNDECANE; PENTACYCLOUNDECANE,; PENTACYCLOUNDECANE.; TRISHOMOCUBANE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; TUBERCULOSIS;

ALKANES; ANTITUBERCULAR AGENTS; DIAMINES; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; POLYCYCLIC COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864412452     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.041     Document Type: Article

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