Synthesis, antimicrobial and cytotoxic activities of sulfone linked bis heterocycles

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 605-614

  Muralikrishna, A ^a   Venkatesh, B C ^a   Padmavathi, V ^a   Padmaja, A ^a   Kondaiah, P ^b   Krishna, N Siva ^b  

^a SRI VENKATESWARA UNIVERSITY   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

1,3 Dipolar cycloaddition; Antimicrobial activity; Cytotoxicity; Oxadiazoles; Pyrazoles; Pyrroles; Thiadiazoles; Triazoles

Indexed keywords

2 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA CHLOROPHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 OXADIAZOLE; 2 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA CHLOROPHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 THIADIAZOLE; 2 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 (4 PARA CHLOROPHENYLSULFONYL 1'H PYRROL 3' YLSULFONYLMETHYL) 1,3,4 THIADIAZOLE; 2 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 [(2 PARA CHLOROPHENYLSULFONYLVINYL SULFONYLMETHYL)] 1,3,4 OXADIAZOLE; 2 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA METHYLPHENYLSULFONYL 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 OXADIAZOLE; 2 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA METHYLPHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 OXADIAZOLE; 2 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA METHYLPHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 THIADIAZOLE; 2 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 (4' PARA METHYLPHENYLSULFONYL 1'H PYRROL 3' YLSULFONYLMETHYL) 1,3,4 THIADIAZOLE; 2 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 [(2 PARA METHYLPHENYLSULFONYLVINYL SULFONYLMETHYL)] 1,3,4 OXADIAZOLE; 2 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 [(2 PARA METHYLPHENYLSULFONYLVINYL SULFONYLMETHYL)] 1,3,4 THIADIAZOLE; 2 (PHENYLAMINOSULFONYLMETHYL) 5 (3' PHENYLSULFONYL 1'H PYRAZOL 4' YLSULFONYL METHYL) 1,3,4 OXADIAZOLE; 2 (PHENYLAMINOSULFONYLMETHYL) 5 (3' PHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 OXADIAZOLE; 2 (PHENYLAMINOSULFONYLMETHYL) 5 (3' PHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,3,4 THIADIAZOLE; 2 (PHENYLAMINOSULFONYLMETHYL) 5 (4' PHENYLSULFONYL 1'H PYRROL 3' YLSULFONYL METHYL) 1,3,4 THIADIAZOLE; 2 (PHENYLAMINOSULFONYLMETHYL) 5 [(2 PHENYLSULFONYLVINYLSULFONYLMETHYL)] 1,3,4 OXADIAZOLE; 2 (PHENYLAMINOSULFONYLMETHYL) 5 [(2 PHENYLSULFONYLVINYLSULFONYLMETHYL)] 1,3,4 THIADIAZOLE; 4 AMINO 3 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA CHLOROPHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; 4 AMINO 3 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 (4' PARA CHLOROPHENYLSULFONYL 1'H PYRROL 3' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; 4 AMINO 3 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 [(2 PARA CHLOROPHENYLSULFONYL VINYLSULFONYLMETHYL)] 1,2,4 TRIAZOLE; 4 AMINO 3 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA METHYLPHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; 4 AMINO 3 (4 METHYLPHENYLAMINOSULFONYLMETHYL) 5 (4' PARA METHYLPHENYLSULFONYL 1'H PYRROL 3' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; 4 AMINO 3 (PHENYLAMINOSULFONYLMETHYL) 5 (3' PHENYLSULFONYL 4',5' DIHYDRO 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; 4 AMINO 3 (PHENYLAMINOSULFONYLMETHYL) 5 (4' PHENYLSULFONYL 1'H PYRROL 3' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; AMINO 3 (4 CHLOROPHENYLAMINOSULFONYLMETHYL) 5 (3' PARA CHLOROPHENYLSULFONYL 1'H PYRAZOL 4' YLSULFONYLMETHYL) 1,2,4 TRIAZOLE; CHLORAMPHENICOL; HETEROCYCLIC COMPOUND; KETOCONAZOLE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINYLSULFONYL OXADIAZOLE;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; KLEBSIELLA PNEUMONIAE; LUNG CARCINOMA; NONHUMAN; PENICILLIUM CHRYSOGENUM; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; SUBSTITUTION REACTION;

ANTI-INFECTIVE AGENTS; BACTERIA; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; FUNGI; HETEROCYCLIC COMPOUNDS; HUMANS; SULFONES;

EID: 84864410380     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.014     Document Type: Article

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