Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent

Journal of Experimental Therapeutics and Oncology

Volumn 10, Issue 1, 2012, Pages 51-64

  Deeb, Dorrah ^a   Gao, Xiaohua ^a   Liu, Yong Bo ^a   Gautam, Subhash C ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

Akt; Apoptosis; CDDO Me; Erk1 2; MTOR; Nf B; Pancreatic cancer; ROS

Indexed keywords

ACETYLCYSTEINE; ANNEXIN; BARDOXOLONE METHYL; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C; DIPHYLENE IODONIUM; ENZYME INHIBITOR; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROCASPASE 3; PROCASPASE 8; PROCASPASE 9; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ROTENONE; SUPEROXIDE; SUPEROXIDE DISMUTASE; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

ACETYLCYSTEINE; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLEANOLIC ACID; PANCREATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 84864409970     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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