Design, synthesis and antiviral activity of novel pyridazines

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 33-41

  Wang, Ziwen ^a   Wang, Mingxiao ^a   Yao, Xue ^a   Li, Yue ^a   Tan, Juan ^a   Wang, Lizhong ^a   Qiao, Wentao ^a   Geng, Yunqi ^a   Liu, Yuxiu ^a   Wang, Qingmin ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

Anti HIV activity; Antiviral activity; Pyridazine; Rearrangement; Synthesis

Indexed keywords

2 (4 FLUOROPHENYL) 4 HYDROXY 6 (TRIFLUOROMETHYL)PYRIDAZIN 3(2H) ONE; 4 HYDROXY 2 PHENYL 6 (TRIFLUOROMETHYL)PYRIDAZIN 3(2H) ONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; METHYL 1 (4 FLUOROBENZYL) 5 METHOXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 1 (FURAN 2 YLMETHYL) 5 METHOXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 1 CINNAMYL 5 METHOXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 1 TERT BUTYL 5 METHOXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 1,6 DIHYDRO 5 HYDROXY 6 OXO 1 PHENYL 3 (TRIFLUOROMETHYL) 4 PYRIDAZINECARBOXYLATE; METHYL 1,6 DIHYDRO 5 HYDROXY 6 OXO 1 PHENYL 3 (TRIFLUORORMETHYL) 4 PYRIDAZINECARBOXYLATE; METHYL 1,6 DIHYDRO 5 METHOXY 6 OXO 1 (4 FLUOROPHENYL) 3 (TRIFLUOROMETHYL) 4 PYRIDAZINECARBOXYLATE; METHYL 1,6 DIHYDRO 5 METHOXY 6 OXO 1 (PYRIDIN 2 YLMETHYL) 3 (TRIFLUOROMETHYL) 4 PYRIDAZINECARBOXYLATE; METHYL 1,6 DIHYDRO 5 METHOXY 6 OXO 1 PHENYL 3 (TRIFLUOROMETHYL) 4 PYRIDAZINECARBOXYLATE; METHYL 5 METHOXY 1 METHYL 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 5 METHOXY 6 OXO 1 (PYRIDIN 3 YLMETHYL) 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 5 METHOXY 6 OXO 1 (THIOPHEN 2 YLMETHYL) 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; METHYL 5 METHOXY 6 OXO 1 [(TETRAHYDROFURAN 2 YL)METHYL] 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXYLATE; N (4 FLUOROBENZYL) 1 (4 FLUOROPHENYL) 5 HYDROXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 1 (FURAN 2 YLMETHYL) 5 HYDROXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 (4 FLUOROBENZYLAMINO) 1 (4 FLUOROPHENYL) 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 (4 FLUOROBENZYLAMINO) 6 OXO 1 (THIOPHEN 2 YLMETHYL) 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 1 METHYL 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 6 OXO 1 (PYRIDIN 2 YLMETHYL) 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 6 OXO 1 (PYRIDIN 3 YLMETHYL) 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 6 OXO 1 (THIOPHEN 2 YLMETHYL) 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 6 OXO 1 [(TETRAHYDROFURAN 2 YL)METHYL] 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N (4 FLUOROBENZYL) 5 HYDROXY 6 OXO 1 PHENYL 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; N,1 BIS(4 FLUOROBENZYL) 5 HYDROXY 6 OXO 3 (TRIFLUOROMETHYL) 1,6 DIHYDROPYRIDAZINE 4 CARBOXAMIDE; PYRIDAZINE DERIVATIVE; RIBAVIRIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; IN VIVO STUDY; NONHUMAN; PROCESS OPTIMIZATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TOBACCO MOSAIC VIRUS;

ANTIVIRAL AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV-1; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOBACCO MOSAIC VIRUS;

EID: 84864406737     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.020     Document Type: Article

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