Nanomechanics of superbugs and superdrugs: New frontiers in nanomedicine

Biochemical Society Transactions

Volumn 40, Issue 4, 2012, Pages 603-608

  McKendry, Rachel A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antibiotic resistance; Atomic force microscopy (AFM); Drug resistance; Methicillin resistant Staphylococcus aureus (MRSA); Nanomechanics; Nanomedicine; Superbug; Superdrug

Indexed keywords

VANCOMYCIN;

ATOMIC FORCE MICROSCOPY; BACTERIUM; BIOSENSOR; CELL WALL; CONFERENCE PAPER; CYTOSKELETON; DRUG MECHANISM; ENERGY; HEALTH CARE; INFORMATION TECHNOLOGY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROSCOPE; MOLECULAR MECHANICS; NANOMEDICINE; NANOTECHNOLOGY; NONHUMAN; OPTICAL RESOLUTION; PATHOGENICITY; POINT OF CARE TESTING; PRIORITY JOURNAL;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL WALL; CYTOSKELETON; HUMANS; NANOMEDICINE; NANOTECHNOLOGY;

BACTERIA (MICROORGANISMS); EUKARYOTA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PROKARYOTA;

EID: 84864390085     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120082     Document Type: Conference Paper

References (37)

1. Hopwood, D.A. (2007) A call to arms. Nat. Rev. Drug Discovery 6, 8-12
2. Cooper, M.A. and Shlaes, D. (2011) Fix the antibiotics pipeline. Nature 472, 32
3. Ndieyira, J.W., Watari, M., Barrera, A.D., Zhou, D., Vogtli, M., Batchelor, M., Cooper, M.A., Strunz, T., Horton, M.A., Abell, C. et al. (2008) Nanomechanical detection of antibiotic mucopeptide binding in a model for superbug drug resistance. Nat. Nanotechnol. 3, 691-696
4. Jones, L.J.F., Carballido-Lopez, R. and Errington, J. (2001) Control of cell shape in bacteria: helical, actin-like filaments in Bacillus subtilis. Cell 104, 913-922 (Pubitemid 32289283)
5. Fletcher, D.A. and Mullins, R.D. (2010) Cell mechanics and the cytoskeleton. Nature 463, 485-492
6. Binnig, G.K., Quate, C.F. and Gerber, C. (1986) Atomic force microscope. Phys. Rev. Lett. 56, 930-933
7. Dufrene, Y.F. (2008) Towards nanomicrobiology using atomic force microscopy. Nat. Rev. Microbiol. 6, 674-680
8. Muller, D.J., Baumeister, W. and Engel, A. (1999) Controlled unzipping of a bacterial surface layer with atomic force microscopy. Proc. Natl. Acad. Sci. U.S.A. 96, 13170-13174
9. Hayhurst, E.J., Kailas, L., Hobbs, J.K. and Foster, S.J. (2008) Cell wall peptidoglycan architecture in Bacillus subtilis. Proc. Natl. Acad. Sci. U.S.A. 105, 14603-14608
10. Plomp, M., Leighton, T.J., Wheeler, K.E., Hill, H.D. and Malkin, A.J. (2007) In vitro high-resolution structural dynamics of single germinating bacterial spores. Proc. Natl. Acad. Sci. U.S.A. 104, 9644-9649 (Pubitemid 47175320)
11. Fantner, G.E., Gray, D.S. and Belcher, A.M. (2010) Kinetics of antimicrobial peptide activity measured on individual bacterial cells using high-speed atomic force microscopy. Nat. Nanotechnol. 5, 280-285
12. Raman, A., Trigueros, S., Cartagena, A., Stevenson, A.P., Susilo, M., Nauman, E. and Contera, S.A. (2011) Mapping nanomechanical properties of live cells using multi-harmonic atomic force microscopy. Nat. Nanotechnol. 6, 809-814
13. Pelling, A.E., Li, Y.N., Shi, W.Y. and Gimzewski, J.K. (2005) Nanoscale visualization and characterization of Myxococcus xanthus cells with atomic force microscopy. Proc. Natl. Acad. Sci. U.S.A. 102, 6484-6489 (Pubitemid 40617469)
14. Dupres, V., Menozzi, F.D., Locht, C., Clare, B.H., Abbott, N.L., Cuenot, S., Bompard, C., Raze, D. and Dufrene, Y.F. (2005) Nanoscale mapping and functional analysis of individual adhesins on living bacteria. Nat. Methods 2, 515-520 (Pubitemid 41131157)
15. Gilbert, Y., Deghorain, M., Wang, L., Xu, B., Pollheimer, P.D., Gruber, H.J., Errington, J., Hallet, B., Haulot, X., Verbelen, C. et al. (2007) Single-molecule force spectroscopy and imaging of the vancomycin/D-Ala-D-Ala interaction. Nano Lett. 7, 796-801 (Pubitemid 46516068)
16. Wang, S.Y., Arellano-Santoyo, H., Combs, P.A. and Shaevitz, J.W. (2010) Actin-like cytoskeleton filaments contribute to cell mechanics in bacteria. Proc. Natl. Acad. Sci. U.S.A. 107, 9182-9185
17. Fritz, J., Baller, M.K., Lang, H.P., Rothuizen, H., Vettiger, P., Meyer, E., Guntherodt, H.J., Gerber, C. and Gimzewski, J.K. (2000) Translating biomolecular recognition into nanomechanics. Science 288, 316-318 (Pubitemid 30226188)
18. McKendry, R., Zhang, J.Y., Arntz, Y., Strunz, T., Hegner, M., Lang, H.P., Baller, M.K., Certa, U., Meyer, E., Guntherodt, H.J. and Gerber, C. (2002) Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array. Proc. Natl. Acad. Sci. U.S.A. 99, 9783-9788 (Pubitemid 34831125)
19. Braun, T., Ghatkesar, M.K., Backmann, N., Grange, W., Boulanger, P., Letellier, L., Lang, H.P., Bietsch, A., Gerber, C. and Hegner, M. (2009) Quantitative time-resolved measurement of membrane protein-ligand interactions using microcantilever array sensors. Nat. Nanotechnol. 4, 179-185
20. Backmann, N., Zahnd, C., Huber, F., Bietsch, A., Plückthun, A., Lang, H.P., Güntherodt, H.J., Hegner, M. and Gerber, C. (2005) A label-free immunosensor array using single-chain antibody fragments. Proc. Natl. Acad. Sci. U.S.A. 102, 14857-14592
21. Ghatkesar, M.K., Barwich, V., Braun, T., Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P., Drechsler, U. and Despont, M. (2007) Higher modes of vibration increase mass sensitivity in nanomechanical microcantilevers. Nanotechnology 18, 445502
22. Mertens, J., Rogero, C., Calleja, M., Ramos, D., Martin-Gago, J.A., Briones, C. and Tamayo, J. (2008) Label-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films. Nat. Nanotechnol. 3, 301-307 (Pubitemid 351668057)
23. Ilic, B., Czaplewski, D., Zalalutdinov, M., Craighead, H.G., Neuzil, P., Campagnolo, C. and Batt, C. (2001) Single cell detection with micromechanical oscillators. J. Vac. Sci. Technol. B 19, 2825-2828 (Pubitemid 34089836)
24. Boisen, A. and Thundat, T. (2009) Design and fabrication of cantilever array biosensors. Mater. Today 12, 32-38
25. Arlett, J.L., Myers, E.B. and Roukes, M.L. (2011) Comparative advantages of mechanical biosensors. Nat. Nanotechnol. 6, 203-215
26. Gfeller, K.Y., Nugaeva, N. and Hegner, M. (2005) Micromechanical oscillators as rapid biosensor for the detection of active growth of Escherichia coli. Biosens. Bioelectron. 21, 528-533 (Pubitemid 41074943)
27. Ramos, D., Tamayo, J., Mertens, J., Calleja, M., Villanueva, L.G. and Zaballos, A. (2008) Detection of bacteria based on the thermomechanical noise of a nanomechanical resonator: origin of the response and detection limits. Nanotechnology 19, 035503
28. Gruter, R.R., Khan, Z., Paxman, R., Ndieyira, J.W., Dueck, B., Bircher, B.A., Yang, J.L., Drechsler, U., Despont, M., McKendry, R.A. and Hoogenboom, B.W. (2010) Disentangling mechanical and mass effects on nanomechanical resonators. Appl. Phys. Lett. 96, 023113
29. Burg, T.P., Knudsen, S.M., Shen, W., Carlson, G., Foster, J.S., Babcock, K. and Manalis, S.R. (2007) Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446, 1066-1069 (Pubitemid 46676057)
30. Zhang, J., Lang, H.P., Huber, F., Bietsch, A., Grange, W., Certa, U., McKendry, R., Hegner, M. and Gerber, C. (2006) Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA. Nat. Nanotechnol. 1, 214-220
31. Shu, W.M., Liu, D.S., Watari, M., Riener, C.K., Strunz, T., Welland, M.E., Balasubramanian, S. and McKendry, R.A. (2005) DNA molecular motor driven micromechanical cantilever arrays. J. Am. Chem. Soc. 127, 17054-17060 (Pubitemid 41772866)
32. Watari, M., Galbraith, J., Lang, H.P., Sousa, M., Hegner, M., Gerber, C., Horton, M.A. and McKendry, R.A. (2007) Investigating the molecular mechanisms of in-plane mechanochemistry on cantilever arrays. J. Am. Chem. Soc. 129, 601-609 (Pubitemid 46147760)
33. Sushko, M.L., Harding, J.H., Shluger, A.L., McKendry, R.A. and Watari, M. (2008) Physics of nanomechanical biosensing on cantilever arrays. Adv. Mater. 20, 3848
34. Watari, M., Ndieyira, J.W. and McKendry, R.A. (2010) Chemically programmed nanomechanical motion of multiple cantilever arrays. Langmuir 26, 4623-4626
35. Ransley, J.H.T., Watari, M., Sukumaran, D., McKendry, R.A. and Seshia, A.A. (2006) SU8 bio-chemical sensor microarrays. Microelectron. Eng. 83, 1621-1625
36. Watari, M., McKendry, R.A., Vogtli, M., Aeppli, G., Soh, Y.A., Shi, X.W., Xiong, G., Huang, X.J. and Robinson, I.K. (2011) Differential stress induced by thiol adsorption on facetted nanocrystals. Nat. Mater. 10, 862-866
37. Williams, D.H. and Bardsley, B. (1999) The vancomycin group of antibiotics and the fight against resistant bacteria. Angew. Chem. Int. Ed. 38, 1173-1193 (Pubitemid 29234577)