Joint effects of genetic variants in multiple loci on the risk of coronary artery disease in Chinese Han subjects

Circulation Journal

Volumn 76, Issue 8, 2012, Pages 1987-1992

  Lv, Xiaofei ^a   Zhang, Yuan ^b   Rao, Shaoqi ^d   Qiu, Jian ^b   Wang, Min ^a   Luo, Xiaoqin ^a   Zuo, Xiaoyu ^a   Su, Dongfang ^a   Feng, Xiang ^a   Yang, Yan ^a   Ouyang, Ping ^d   Chen, Yibing ^c   Li, Xinrui ^a   Xiao, Yunjun ^a   Ling, Wenhua ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangzhou Military Region General Hospital   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^d GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Coronary artery disease; Genetic risk score; Genetic variants; Joint effect

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHINESE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; CORONARY ARTERY DISEASE; FEMALE; GENETIC LOCI; HUMANS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; ROC CURVE;

EID: 84864387179     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-0156     Document Type: Article

References (43)

1. McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316: 1488-1491.
2. Samani NJ, Deloukas P, Erdmann J, Hengstenberg C, Kuulasmaa K, McGinnis R, et al. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol 2009; 29: 774-780.
3. Kalyanasundaram A, Gerhard GS, Skelding KA. Genomics, haplotypes and cardiovascular disease. Future Cardiol 2007; 3: 601-610.
4. Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007; 357: 443-453.
5. Tregouet DA, Konig IR, Erdmann J, Munteanu A, Braund PS, Hall AS, et al. Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nat Genet 2009; 41: 283-285.
6. Myers MG, Cowley MA, Munzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 2008; 70: 537-556.
7. Pare G, Serre D, Brisson D, Anand SS, Montpetit A, Tremblay G, et al. Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. Am J Hum Genet 2007; 80: 673-682.
8. Kathiresan S, Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466: 707-713.
9. Park MH, Kim N, Lee JY, Park HY. Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. J Med Genet 2011; 48: 10-15.
10. Li SJ, Hu WL, Liu DT, Sun FH, Zhang Q, Yang XC, et al. MTAP gene is associated with ischemic stroke in Chinese Hans. J Neurol Sci 2009; 284: 103-107.
11. Companioni O, Rodriguez Esparragon F, Medina Fernandez-Aceituno A, Rodriguez Perez JC. Genetic variants, cardiovascular risk and genome-wide association studies. Rev Esp Cardiol 2011; 64: 509-514.
12. Hiura Y, Tabara Y, Kokubo Y, Okamura T, Goto Y, Nonogi H, et al. Association of the functional variant in the 3-hydroxy-3-methylglutarylcoenzyme A reductase gene with low-density lipoprotein-cholesterol in Japanese. Circ J 2010; 74: 518-522.
13. Kang G, Guo L, Guo Z, Hu X, Wu M, Zhou Z, et al. Impact of blood pressure and other components of the metabolic syndrome on the development of cardiovascular disease. Circ J 2010; 74: 456-461.
14. Horne BD, Anderson JL, Carlquist JF, Muhlestein JB, Renlund DG, Bair TL, et al. Generating genetic risk scores from intermediate phenotypes for use in association studies of clinically significant endpoints. Ann Hum Genet 2005; 69: 176-186.
15. Morrison AC, Bare LA, Chambless LE, Ellis SG, Malloy M, Kane JP, et al. Prediction of coronary heart disease risk using a genetic risk score: The Atherosclerosis Risk in Communities Study. Am J Epidemiol 2007; 166: 28-35.
16. Guella I, Duga S, Ardissino D, Merlini PA, Peyvandi F, Mannucci PM, et al. Common variants in the haemostatic gene pathway contribute to risk of early-onset myocardial infarction in the Italian population. Thromb Haemost 2011; 106: 655-664.
17. Anderson JL, Horne BD, Camp NJ, Muhlestein JB, Hopkins PN, Cannon-Albright LA, et al. Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease. Am Heart J 2010; 160: 250-2563.
18. Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, et al. A multilocus genetic risk score for coronary heart disease: Case-control and prospective cohort analyses. Lancet 2010; 376: 1393-1400.
19. Dupont WD, Plummer WD Jr. Power and sample size calculations for studies involving linear regression. Control Clin Trials 1998; 19: 589-601.
20. Chen H, Poon A, Yeung C, Helms C, Pons J, Bowcock AM, et al. A genetic risk score combining ten psoriasis risk loci improves disease prediction. Plos One 2011; 6: e19454.
21. Antolini L, Nam BH, D'Agostino RB. Inference on correlated discrimination measures in survival analysis: A nonparametric approach. Commun Stat Theory Methods 2004; 33: 2117-2135.
22. Shen GQ, Li L, Rao S, Abdullah KG, Ban JM, Lee BS, et al. Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease. Arterioscler Thromb Vasc Biol 2008; 28: 360-365.
23. Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet 2008; 40: 149-151.
24. Dumitrescu L, Carty CL, Taylor K, Schumacher FR, Hindorff LA, Ambite JL, et al. Genetic determinants of lipid traits in diverse populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study. PLoS Genet 2011; 7: e1002138.
25. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, et al. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2009; 41: 56-65.
26. Nakayama K, Bayasgalan T, Tazoe F, Yanagisawa Y, Gotoh T, Yamanaka K, et al. A single nucleotide polymorphism in the FADS1/ FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. Hum Genet 2010; 127: 685-690.
27. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40: 161-169.
28. Liu Y, Zhou D, Zhang Z, Song Y, Zhang D, Zhao T, et al. Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population. J Lipid Res 2011; 52: 354-360.
29. Middelberg RP, Ferreira MA, Henders AK, Heath AC, Madden PA, Montgomery GW, et al. Genetic variants in LPL, OASL and TOMM40/ APOE-C1-C2-C4 genes are associated with multiple cardiovascularrelated traits. BMC Med Genet 2011; 12: 123.
30. Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes 2011; 60: 1329-1339.
31. Qi L, Ma J, Qi Q, Hartiala J, Allayee H, Campos H. Genetic risk score and risk of myocardial infarction in Hispanics. Circulation 2011; 123: 374-380.
32. Ding H, Xu Y, Wang X, Wang Q, Zhang L, Tu Y, et al. 9p21 is a shared susceptibility locus strongly for coronary artery disease and weakly for ischemic stroke in Chinese Han population. Circ Cardiovasc Genet 2009; 2: 338-346.
33. Harismendy O, Notani D, Song X, Rahim N, Tanasa B, Heintzman N, et al. 9p21 DNA variants associated with coronary artery disease impair INF-γ signalling response. Nature 2011; 470: 264-268.
34. Companioni O, Rodriguez Esparragon F, Fernandez-Aceituno AM, Rodriguez Perez JC. Genetic variants, cardiovascular risk and genomewide association studies. Rev Esp Cardiol 2011; 64: 509-514.
35. Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, et al. Comparative analysis of genome-wide-association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J 2012; 33: 393-407.
36. Franceschini N, Carty C, Buzkova P, Reiner A, Garrett T, Lin Y, et al. Association of genetic variants and incident coronary heart disease in multi-ethnic cohorts. The PAGE Study. Circ Cardiovasc Genet 2011; 4: 661-672.
37. Bressler J, Folsom AR, Couper DJ, Volcik KA, Boerwinkle E. Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study. Am J Epidemiol 2010; 171: 14-23.
38. Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, et al. Genetic loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA 2009; 302: 37-48.
39. Haiman CA, Le Marchand L, Yamamato J, Stram DO, Sheng X, Kolonel LN, et al. A common genetic risk factor for colorectal and prostate cancer. Nat Genet 2007; 39: 954-956.
40. Qi L, Cho YA. Gene-environment interaction and obesity. Nutr Rev 2008; 66: 684-694.
41. Paynter NP, Chasman DI, Pare G, Buring JE, Cook NR, Miletich JP, et al. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA 2010; 303: 631-637.
42. van der Net JB, van Etten J, Yazdanpanah M, Dallinga-Thie GM, Kastelein JJ, Defesche JC, et al. Gene-load score of the renin-angiotensinaldosterone system is associated with coronary heart disease in familial hypercholesterolaemia. Eur Heart J 2008; 29: 1370-1376.
43. Horvath S, Xu X, Laird NM. The family based association test method: Strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001; 9: 301-306.