Lipofuscin can be eliminated from the retinal pigment epithelium of monkeys

Neurobiology of Aging

Volumn 33, Issue 10, 2012, Pages 2390-2397

  Julien, Sylvie ^a   Schraermeyer, Ulrich ^a  

^a Centre for Ophthalmology   (Germany)

Author keywords

Age related macular degeneration; Cynomolgus monkey; Electron microscopy; Lipofuscin; Retinal pigment epithelium

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; LIPOFUSCIN; REMOFUSCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; EXOCYTOSIS; FLUORESCENCE MICROSCOPY; MACACA FASCICULARIS; MACROPHAGE; MELANOCYTE; MELANOSOME; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT DURATION;

ANIMALS; IMIDAZOLES; LIPOFUSCIN; MACACA FASCICULARIS; MACROPHAGES; MACULAR DEGENERATION; NAPHTHYRIDINES; RETINAL PIGMENT EPITHELIUM;

EID: 84864385517     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.12.009     Document Type: Article

References (36)

1. Andrews L.D., Brizzee K.R. Lipofuscin in retinal pigment epithelium of rhesus monkey: lack of diminution with centrophenoxine treatment. Neurobiol. Aging 1986, 7:107-113.
2. Biesemeier A., Schraermeyer U., Eibl O. Chemical composition of melanosomes, lipofuscin and melanolipofuscin granules of human RPE tissues. Exp. Eye Res 2011, 93:29-39.
3. Bok D. The retinal pigment epithelium: a versatile partner in vision. J. Cell Sci. Suppl 1993, 17:189-195.
4. Brunk U.T., Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic. Biol. Med 2002, 33:611-619.
5. Buschini E., Piras A., Nuzzi R., Vercelli A. Age related macular degeneration and drusen: Neuroinflammation in the retina. Prog. Neurobiol 2011, 95:14-25.
6. Dylewski D.P., Nandy S., Nandy K. Effects of centrophenoxine on lipofuscin in the retinal pigment epithelium of old mice. Neurobiol. Aging 1983, 4:89-95.
7. Eldred G.E. Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration. Gerontology 1995, 41(suppl 2):15-28.
8. Finnemann S.C., Leung L.W., Rodriguez-Boulan E. The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:3842-3847.
9. Godley B.F., Shamsi F.A., Liang F.Q., Jarrett S.G., Davies S., Boulton M. Blue light induces mitochondrial DNA damage and free radical production in epithelial cells. J. Biol. Chem 2005, 280:21061-21066.
10. Golczak M., Kuksa V., Maeda T., Moise A.R., Palczewski K. Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:8162-8167.
11. Holz F.G., Bindewald-Wittich A., Fleckenstein M., Dreyhaupt J., Scholl H.P., Schmitz-Valckenberg S. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am. J. Ophthalmol 2007, 143:463-472. FAM-Study Group.
12. Holz F.G., Schütt F., Kopitz J., Eldred G.E., Kruse F.E., Völcker H.E., Cantz M. Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin. Invest. Ophthalmol. Vis. Sci 1999, 40:737-743.
13. Katz M.L., Robison W.G. Lipofuscin response to the "aging-reversal" drug centrophenoxine in rat retinal pigment epithelium and frontal cortex. J. Gerontol 1983, 38:525-531.
14. Kong J., Kim S.R., Binley K., Pata I., Doi K., Mannik J., Zernant-Rajang J., Kan O., Iqball S., Naylor S., Sparrow J.R., Gouras P., Allikmets R. Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy. Gene Ther 2008, 15:1311-1320.
15. Kopitz J., Holz F.G., Kaemmerer E., Schutt F. Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie 2004, 86:825-831.
16. Maiti P., Kong J., Kim S.R., Sparrow J.R., Allikmets R., Rando R.R. Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry 2006, 45:852-860.
17. Nandy K., Bourne G.H. Effect of centrophenoxine on the lipofuscin pigments in the neurones of senile guinea-pigs. Nature 1966, 210:313-314.
18. Ng K.P., Gugiu B., Renganathan K., Davies M.W., Gu X., Crabb J.S., Kim S.R., Rózanowska M.B., Bonilha V.L., Rayborn M.E., Salomon R.G., Sparrow J.R., Boulton M.E., Hollyfield J.G., Crabb J.W. Retinal pigment epithelium lipofuscin proteomics. Mol. Cell. Proteomics 2008, 7:1397-1405.
19. Nilsson S.E., Sundelin S.P., Wihlmark U., Brunk U.T. Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage. Doc. Ophthalmol 2003, 106:13-16.
20. Ohtani R., Kawashima S. Reduction of lipofuscin by centrophenoxine and chlorpromazine in the neurons of rat cerebral hemisphere in primary culture. Exp. Gerontol 1983, 18:105-112.
21. Patro N., Sharma S.P., Patro I.K. Lipofuscin accumulation in ageing myocardium & its removal by meclophenoxate. Indian J. Med. Res 1992, 96:192-198.
22. Radu R.A., Han Y., Bui T.V., Nusinowitz S., Bok D., Lichter J., Widder K., Travis G.H., Mata N.L. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest. Ophthalmol. Vis. Sci 2005, 46:4393-4401.
23. Radu R.A., Hu J., Yuan Q., Welch D.L., Makshanoff J., Lloyd M., McMullen S., Travis G.H., Bok D. Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration. J. Biol. Chem 2011, 286:18593-18601.
24. Rózanowska M., Pawlak A., Rózanowski B., Skumatz C., Zareba M., Boulton M.E., Burke J.M., Sarna T., Simon J.D. Age-related changes in the photoreactivity of retinal lipofuscin granules: role of chloroform-insoluble components. Invest. Ophthalmol. Vis. Sci 2004, 45:1052-1060.
25. Schmitz-Valckenberg S., Bindewald-Wittich A., Dolar-Szczasny J., Dreyhaupt J., Wolf S., Scholl H.P., Holz F.G. Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest. Ophthalmol. Vis. Sci 2006, 47:2648-2654. Fundus Autofluorescence in Age-Related Macular Degeneration Study Group.
26. Shamsi F.A., Boulton M. Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin. Invest. Ophthalmol. Vis. Sci 2001, 42:3041-3046.
27. Sparrow J.R. Bisretinoids of RPE lipofuscin: trigger for complement activation in age-related macular degeneration. Adv. Exp. Med. Biol 2010, 703:63-74.
28. Sparrow J.R., Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp. Eye Res 2005, 80:595-606.
29. Sparrow J.R., Fishkin N., Zhou J., Cai B., Jang Y.P., Krane S., Itagaki Y., Nakanishi K. A2E, a byproduct of the visual cycle. Vision Res 2003, 43:2983-2990.
30. Sundelin S., Wihlmark U., Nilsson S.E., Brunk U.T. Lipofuscin accumulation in cultured retinal pigment epithelial cells reduces their phagocytic capacity. Curr. Eye Res 1998, 17:851-857.
31. Terman A. Catabolic insufficiency and aging. Ann. N. Y. Acad. Sci 2006, 1067:27-36.
32. Terman A., Brunk U.T. On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes. Mech. Ageing Dev 1998, 100:145-156.
33. Vives-Bauza C., Anand M., Shirazi A.K., Magrane J., Gao J., Vollmer-Snarr H.R., Manfredi G., Finnemann S.C. The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells. J. Biol. Chem 2008, 283:24770-24780.
34. Wu Y., Zhou J., Fishkin N., Rittmann B.E., Sparrow J.R. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc 2011, 133:849-857.
35. Yin D. Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores. Free Radic. Biol. Med 1996, 21:871-888.
36. Zhou J., Kim S.R., Westlund B.S., Sparrow J.R. Complement activation by bisretinoid constituents of RPE lipofuscin. Invest. Ophthalmol. Vis. Sci 2009, 50:1392-1399.