Association of gene polymorphism of the fat mass and obesity associated gene with metabolic syndrome: A retrospective cohort study in Japanese workers

Yonago Acta Medica

Volumn 55, Issue 2, 2012, Pages 29-40

  Kawajiri, Tomoka ^a   Osaki, Yoneatsu ^a   Kishimoto, Takuji ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

Cohort study; Fat mass and obesity associated gene; Japanese worker; Metabolic syndrome; Single nucleotide polymorphism

Indexed keywords

GLUCOSE;

ADULT; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; FAT MASS AND OBESITY ASSOCIATED GENE; FEMALE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; JAPANESE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; POLYMERASE CHAIN REACTION; PREDICTION; RETROSPECTIVE STUDY; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84864384677     PISSN: 05135710     EISSN: 13468049     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Al-Attar SA, Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, et al. Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Cardiovasc Diabetol 2008;7:5.
2. Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, Andersen G, et al. Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 2008;57:95-101.
3. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CNA. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008;359:2558-2566.
4. Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L, et al. Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 2010;42:1086-1093.
5. Dina C, Meyre D, Gallina S, Durand E, Körner A, Jacobson P, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724-726.
6. Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005;365:1415-1428.
7. Fappa E, Yannakoulia M, Pitsavos C, Skoumas I, Valourdou S, Stefanadis C. Lifestyle intervention in the management of metabolic syndrome: could we improve adherence issues? Nutrition 2008;24:286-291.
8. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-898.
9. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:889-894.
10. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007;318:1469-1472.
11. González-Sánchez, JL, Zabena C, Martínez-Larrad MT, Martínez-Calatrava MJ, Pérez-Barba M, Serrano-Ríos M. Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain. Clin Endocrinol 2009;70:390-393.
12. Groop L. Genetics of the metabolic syndrome. Br J Nutr 2000;83(Suppl 1):S39-S48.
13. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-2752.
14. Hinney A, Nguyen TT, Scherag A, Friedel S, Brönner G, Müller TD, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2007;2:e1361.
15. Horikoshi M, Hara K, Ito C, Shojima N, Nagai R, Ueki K, et al. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 2007;50:2461-2466.
16. Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, et al. Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. J Hum Genet 2010;55:738-742.
17. Hotta K, Nakata Y, Matsuko T, Kamohara S, Kotani K, Komatsu R, Itoh N, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet 2008;53:546-553.
18. Karasawa S, Daimon K, Sasaki S, Toriyama S, Oizumi T, Susa S, et al. Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocr J 2010;57:293-301.
19. Li H, Wu Y, Loos RJ, Hu FB, Liu Y, Wang J, et al. Variants in the fat massand obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. Diabetes 2008;57:264-268.
20. Ohashi J, Naka I, Kimura R, Natsuhara K, Yamaguchi T, Furusawa T, et al. FTO polymorphism in oceanic populations. J Hum Genet 2007;52:1031-1035.
21. Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 2008;57:791-795.
22. Otsuka T, Kawada T. Validity of using body mass index as a surrogate measure of abdominal obesity. Circ J 2010;74:383.
23. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007;3:e115.
24. Shimaoka I, Kamide K, Ohishi M, Katsuya T, Akasaka H, Saitoh S, et al. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hyperten Res 2010;33:214-218.
25. Sjögren M, Lyssenko V, Jonsson A, Berglund G, Nilsson P, Groop L, Orho-Melander M. The search for putative unifying genetic factors for components of the metabolic syndrome. Diabetologia 2008;51:2242-2251.
26. Speakman JR, Rance KA, Johnstone AM. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity 2008;16:1961-1965.
27. Tabara Y, Osawa H, Guo H, Kawamoto R, Onuma H, Shimizu I, et al. Prognostic significance of FTO genotype in the development of obesity in Japanese: the JSHIPP study. Int J Obes 2009;33:1243-1248.
28. Tanofsky-Kraff M, Han JC, Anandalingam K, Shomaker LB, Columbo KM, Wolkoff LE, et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nurtr 2009;90:1483-1488.