Comparison of neutralizing antibody and cell-mediated immune responses to pandemic H1N1 2009 influenza virus before and after H1N1 2009 influenza vaccination of elderly subjects and healthcare workers

International Journal of Infectious Diseases

Volumn 16, Issue 8, 2012, Pages

  Hsu, J P ^a   Phoon, M C ^a   Koh, Gerald C H ^b   Chen, Mark I C ^b,c   Lee, Vernon J ^b   Wu, Y ^a   Xie, M L ^a   Cheong, Angela ^b   Leo, Y S ^c   Chow, Vincent T K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c TAN TOCK SENG HOSPITAL   (Singapore)

Author keywords

Antibody; Cell mediated immunity; Influenza; Pandemic H1N1 2009; Vaccination

Indexed keywords

INFLUENZA VACCINE; NEUTRALIZING ANTIBODY;

2009 H1N1 INFLUENZA; ADULT; AGED; AGING; ANIMAL CELL; ANTIBODY TITER; ARTICLE; CELL STRAIN; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HEALTH CARE PERSONNEL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; INFLUENZA VACCINATION; INFLUENZA VIRUS A H1N1; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MORBIDITY; NONHUMAN; PANDEMIC INFLUENZA; PERIPHERAL BLOOD MONONUCLEAR CELL; SEX DIFFERENCE; SINGAPORE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; FEMALE; HUMANS; IMMUNITY, CELLULAR; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED; PANDEMICS; SEX FACTORS; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84864384371     PISSN: 12019712     EISSN: 18783511     Source Type: Journal    
DOI: 10.1016/j.ijid.2012.04.010     Document Type: Article

References (34)

1. Chow V.T., Tambyah P.A., Goh K.T. To kill a mocking bird flu. Ann Acad Med 2008, 37:451-453.
2. Neumann G., Noda T., Kawaoka Y. Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature 2009, 459:931-939.
3. Poland G.A., Jacobson R.M., Targonski P.V. Avian and pandemic influenza: an overview. Vaccine 2007, 25:3057-3061.
4. Dawood F.S., Jain S., Finelli L., Shaw M.W., Lindstrom S., Garten R.J., et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009, 360:2605-2615.
5. Lee V.J., Yap J., Cook A.R., Chen M.I., Tay J.K., Tan B.H., et al. Oseltamivir ring prophylaxis for containment of 2009 H1N1 influenza outbreaks. N Engl J Med 2010, 362:2166-2174.
6. Kasowski E.J., Garten R.J., Bridges C.B. Influenza pandemic epidemiologic and virologic diversity: reminding ourselves of the possibilities. Clin Infect Dis 2011, 52(Suppl 1):S44-S49.
7. Hancock K., Veguilla V., Lu X., Zhong W., Bulter E.N., Sun H., et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med 2009, 361:1945-1952.
8. Lee V.J., Tay J.K., Chen M.I., Phoon M.C., Xie M.L., Wu Y., et al. Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains. Vaccine 2010, 28:6852-6857.
9. Xu R., Ekiert D.C., Krause J.C., Hai R., Crowe J.E., Wilson I.A. Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science 2010, 328:357-360.
10. Cox N.J., Subbarao K. Influenza. Lancet 1999, 354:1277-1282.
11. Valkenburg S.A., Rutigliano J.A., Ellebedy A.H., Doherty P.C., Thomas P.G., Kedzierska K. Immunity to seasonal and pandemic influenza A viruses. Microbes Infect 2011, 13:489-501.
12. Beyer W.E., Palache A.M., Lüchters G., Nauta J., Osterhaus A.D. Seroprotection rate, mean fold increase, seroconversion rate: which parameter adequately expresses seroresponse to influenza vaccination?. Virus Res 2004, 103:125-132.
13. Ellebedy A.H., Webby R.J. Influenza vaccines. Vaccine 2009, 27(Suppl 4):D65-D68.
14. McMurry J.A., Johansson B.E., De Groot A.S. A call to cellular and humoral arms: enlisting cognate T cell help to develop broad-spectrum vaccines against influenza A. Hum Vaccin 2008, 4:148-157.
15. Karlsson A.C., Martin J.N., Younger S.R., Bredt B.M., Epling L., Ronquillo R., et al. Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods 2003, 283:141-153.
16. Tan A.T., Loggi E., Boni C., Chia A., Gehring A.J., Sastry K.S., et al. Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire. J Virol 2008, 82:10986-10997.
17. Moodie Z., Price L., Gouttefangeas C., Mander A., Janetzki S., Löwer M., et al. Response definition criteria for ELISPOT assays revisited. Cancer Immunol Immunother 2010, 59:1489-1501.
18. Wu J., Zhong X., Li C.K., Zhou J.F., Lu M., Huang K.Y., et al. Optimal vaccination strategies for 2009 pandemic H1N1 and seasonal influenza vaccines in humans. Vaccine 2011, 29:1009-1016.
19. Kao T.M., Hsieh S.M., Kung H.C., Lee Y.C., Huang K.C., Huang L.M., et al. Immune response of single dose vaccination against 2009 pandemic influenza A (H1N1) in the Taiwanese elderly. Vaccine 2010, 28:6159-6163.
20. Berthoud T.K., Hamill M., Lillie P.J., Hwenda L., Collins K.A., Ewer K.J., et al. Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. Clin Infect Dis 2011, 52:1-7.
21. Crowe B.A., Brühl P., Gerencer M., Schwendinger M.G., Pilz A., Kistner O., et al. Evaluation of the cellular immune responses induced by a non-adjuvanted inactivated whole virus A/H5N1/VN/1203 pandemic influenza vaccine in humans. Vaccine 2010, 29:166-173.
22. Co M.D., Orphin L., Cruz J., Pazoles P., Rothman A.L., Ennis F.A., et al. Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine. Vaccine 2008, 26:1990-1998.
23. Bellei N.C., Carraro E., Castelo A., Granato C.F. Risk factors for poor immune response to influenza vaccination in elderly people. Braz J Infect Dis 2006, 10:269-273.
24. Goronzy J.J., Fulbright J.W., Crowson C.S., Poland G.A., O'Fallon W.M., Weyand C.M. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001, 75:12182-12187.
25. Phair J., Kauffman C.A., Bjornson A., Adams L., Linnemann C. Failure to respond to influenza vaccine in the aged: correlation with B-cell number and function. J Lab Clin Med 1978, 92:822-828.
26. Woodland D.L., Blackman M.A. Immunity and age: living in the past?. Trends Immunol 2006, 27:303-307.
27. Greenbaum J.A., Kotturi M.F., Kim Y., Oseroff C., Vaughan K., Salimi N., et al. Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population. Proc Natl Acad Sci U S A 2009, 106:20365-20370.
28. He X.S., Mahmood K., Maecker H.T., Holmes T.H., Kemble G.W., Arvin A.M., et al. Analysis of the frequencies and of the memory T cell phenotypes of human CD8+ T cells specific for influenza A viruses. J Infect Dis 2003, 187:1075-1084.
29. Chen M.I., Lee V.J., Lim W.Y., Barr I.G., Lin R.T., Koh G.C., et al. 2009 influenza A(H1N1) seroconversion rates and risk factors among distinct adult cohorts in Singapore. JAMA 2010, 303:1383-1391.
30. Skowronski D.M., De Serres G., Crowcroft N.S., Janjua N.Z., Boulianne N., Hottes T.S., et al. Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during spring-summer 2009: four observational studies from Canada. PLoS Med 2010, 7:e1000258.
31. Lee C.X., Poh W.P., Sakharkar K.R., Sakharkar M.K., Chow V.T. Differences between predicted cytotoxic T-lymphocyte epitopes of 2009 H1N1 swine-origin influenza virus compared with other H1N1 strains of 1918, 1934 and 2007 for HLA-A*0201, HLA-A*1101, and HLA-A*2402 alleles: clinical implications. Int J Integr Biol 2010, 10:124-131.
32. Lee V.J., Tok M.Y., Chow V.T., Phua K.H., Ooi E.E., Tambyah P.A., et al. Economic analysis of pandemic influenza vaccination strategies in Singapore. PLoS One 2009, 4:e7108.
33. Poh W.P., Narasaraju T., Pereira N.A., Zhong F., Phoon M.C., Macary P.A., et al. Characterization of cytotoxic T-lymphocyte epitopes and immune responses to SARS coronavirus spike DNA vaccine expressing the RGD-integrin-binding motif. J Med Virol 2009, 81:1131-1139.
34. Subbramanian R.A., Basha S., Shata M.T., Brady R.C., Bernstein D.I. Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination. Vaccine 2010, 28:8258-8267.