A magnetic resonance spectroscopy study of the anterior cingulate cortex in youth with emotional dysregulation

Israel Journal of Psychiatry and Related Sciences

Volumn 49, Issue 1, 2012, Pages 62-69

  Wozniak, Janet ^a,c   Gönenç, Atilla ^b,c   Biederman, Joseph ^a,c   Moore, Constance ^d   Joshi, Gagan ^a,c   Georgiopoulos, Anna ^a,c   Hammerness, Paul ^a,c   McKillop, Hannah ^a   Lukas, Scott E ^b,c   Henin, Aude ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MCLEAN HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; BEHAVIOR DISORDER; CHILD; CINGULATE GYRUS; EMOTIONAL DISORDER; FEMALE; HUMAN; MALE; METABOLISM; PROCEDURES; PROTON NUCLEAR MAGNETIC RESONANCE;

ADOLESCENT; AFFECTIVE SYMPTOMS; CHILD; CHILD BEHAVIOR DISORDERS; FEMALE; GYRUS CINGULI; HUMANS; MALE; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

EID: 84864384286     PISSN: 03337308     EISSN: 26172402     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Staton D, Volness LJ, Beatty WW. Diagnosis and classification of pediatric bipolar disorder. J Affect Disord 2008;105:205-212.
2. Wozniak J. Pediatric Bipolar disorder: The new perspective on severe mood dysfunction in children. J Child Adolesc Psychopharmacology 2003;13:449-451.
3. Towbin KE, Dykens EM, Pearson GS, Cohen DJ. Conceptualizing "borderline syndrome of childhood" and "childhood schizophrenia" as a developmental disorder. J Am Acad Child Adolesc Psychiatry 1993;32:775-782.
4. Carlson GA. Who are the children with severe mood dysregulation, a.k.a. "rages"? Am J Psychiatry 2007;164:1140-1142.
5. Leibenluft E, Charney D, Towbin K, Bhangoo R, Pine D. Defining clinical phenotypes of juvenile mania. Am J Psychiatry 2003;160:430-437.
6. Holtmann M, Goth K, Wockel L, Poustka F, Bolte S. CBCL-pediatric bipolar disorder phenotype: Severe ADHD or bipolar disorder? J Neural Transm 2008;115:155-161.
7. McClellan J, Kowatch R, Findling RL. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2007;46:107-125.
8. Barkley R. Attention-deficit/hyperactivity disorder, self-regulation, and time: Toward a more comprehensive theory. Dev Behav Pediatrics 1997;18:271-279.
9. Achenbach T, Edelbrock C. Manual for the child behavior checklist and revised child behavior profile. Burlington, Vt.: Department of Psychiatry, University of Vermont, 1983.
10. Achenbach TM. "Comorbidity" in child and adolescent psychiatry: Categorical and quantitative perpectives. J Child Adolesc Psychopharmacology 1990 (1991);1:271-278.
11. Achenbach TM. Manual for the child behavior checklist/4-18 and the 1991 profile. Burlington, Vt.: University of Vermont, Department of Psychiatry, 1991.
12. Achenbach TM. Empirically based taxonomy: How to use syndromes and profile types derived from the CBCL/4-18, TRF, and YSR. Burlington, Vt.: University of Vermont Department of Psychiatry, 1993.
13. Achenbach TM. Manual for the child behavior checklist/1-1/2-5. Burlington, Vt.: ASEBA, 2000.
14. Achenbach TM, Dumenci L. Advances in empirically based assessment: revised cross-informant syndromes and new DSM-oriented scales for the CBCL, YSR, and TRF: Comment on Lengua, Sadowksi, Friedrich, and Fischer (2001). J Consult Clin Psychol 2001;69:699-702.
15. Achenbach TM, Edelbrock C. The child behavior checklist. Burlington, Vt.: University Associates in Psychiatry, 1983.
16. Achenbach TM, Howell CT, McConaughy ST, Stranger C. Six-year predictors of problems in a national sample of children and youth: I. Cross-informant syndromes. J Am Acad Child Adolesc Psychiatry 1995;34: pages?.
17. Achenbach TM, McConaughy SH. Empirically based assessment of child and adolescent psychopathology: Practical applications. Kazdin AE, editor. Newbury Park, Cal.: Sage, 1987.
18. Achenbach TM, Verhulst FC, Baron GD, Althaus M. A comparison of syndromes derived from the child behavior checklist for American and Dutch boys aged 6-11 and 12-16. J Child Psychol Psychiatry 1987;28:437-453.
19. Meyer SE, Carlson GA, Youngstrom E, Ronsaville DS, Martinez PE, Gold PW, et al. Long-term outcomes of youth who manifested the CBCL-Pediatric Bipolar Disorder phenotype during childhood and/or adolescence. J Affect Disord 2009;113:227-235.
20. Holtmann M, Bolte S, Goth K, Dopfner M, Pluck J, Huss M, et al. Prevalence of the child behavior checklist-pediatric bipolar disorder phenotype in a German general population sample. Bipolar Disord 2007;9:895-900.
21. Hudziak JJ, Althoff RR, Derks EM, Faraone SV, Boomsma DI. Prevalence and genetic architecture of Child Behavior Checklist-juvenile bipolar disorder. Biol Psychiatry 2005;58:562-568.
22. Volk HE, Todd RD. Does the child behavior checklist juvenile bipolar disorder phenotype identify bipolar disorder? Biol Psychiatry 2007;62:115-120.
23. Ayer L, Althoff R, Ivanova M, Rettew D, Waxler E, Sulman J, et al. Child behavior checklist juvenile bipolar disorder (CBCL-JBD) and CBCL posttraumatic stress problems (CBCL-PTSP) scales are measures of a single dysregulatory syndrome. J Child Psychol Psychiatry 2009;50:1291-300.
24. Althoff RR, Rettew DC, Ayer LA, Sulman JS, Hudziak JJ. Requiem to the CBCL-Mania proxy. Pediatric Bipolar Conference, 2008, March 28-29; Boston, Mass., 2008.
25. Biederman J, Wozniak J, Kiely K, Ablon S, Faraone S, Mick E, et al. CBCL clinical scales discriminate prepubertal children with structured-interview derived diagnosis of mania from those with ADHD. J Am Acad Child Adolesc Psychiatry 1995;34:464-471.
26. Mick E, Biederman J, Pandina G, Faraone SV. A preliminary meta- analysis of the child behavior checklist in pediatric bipolar disorder. Biol Psychiatry 2003;53:1021-1027.
27. McGough JJ, Loo SK, McCracken JT, Dang J, Clark S, Nelson SF, et al. CBCL pediatric bipolar disorder profile and ADHD: Comorbidity and quantitative trait loci analysis. J Am Acad Child Adolesc Psychiatry 2008;47:1151-1157.
28. Diler RS, Birmaher B, Axelson D, Goldstein B, Gill M, Strober M, et al. The child behavior checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder. J Child Adolesc Psychopharmacol 2009;19:23-30.
29. Faraone SV, Althoff RR, Hudziak JJ, Monuteaux MC, Biederman J. The CBCL predicts DSM bipolar disorder in children: A receiver operating characteristic curve analysis. Bipolar Disord 2005;7:518-524.
30. Biederman J, Petty CR, Monuteaux MC, Evans M, Parcell T, Faraone SV, et al. The child behavior checklist-pediatric bipolar disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: A longitudinal analysis. J Clin Psychiatry 2009;70:732-740.
31. Novotny EJ, Jr, Fulbright RK, Pearl PL, Gibson KM, Rothman DL. Magnetic resonance spectroscopy of neurotransmitters in human brain. Ann Neurol 2003;54:S25-31.
32. Benes FM. Altered glutamatergic and GABAergic mechanisms in the cingulate cortex of the schizophrenic brain. Arch Gen Psychiatry 1995;52:1015-1018; discussion 9-24.
33. Carrey N, MacMaster FP, Sparkes SJ, Khan SC, Kusumakar V. Glutamatergic changes with treatment in attention deficit hyperactivity disorder: A preliminary case series. J Child Adolesc Psychopharmacol 2002;12:331-336.
34. Coyle JT. The glutamatergic dysfunction hypothesis for schizophrenia. Harv Rev Psychiatry 1996;3:241-253.
35. Goff DC, Coyle JT. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 2001;158:1367-1377.
36. Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, et al. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry 2002;7:S71-80.
37. Mirza Y, Tang J, Russell A, Banerjee SP, Bhandari R, Ivey J, et al. Reduced anterior cingulate cotrex glutamatergic concentrations in childhood major depression. J Am Acad Child Adolesc Psychiatry 2004;43:341-348.
38. Moghaddam B. Stress activation of glutamate neurotransmission in the prefrontal cortex: Implications for dopamine-associated psychiatric disorders. Biol Psychiatry 2002;51:775-787.
39. Moore CM, Biederman J, Wozniak J, Mick E, Aleardi M, Wardrop M, et al. Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: A proton magnetic resonance spectroscopy study of the anterior cingulate cortex. J Affect Disord 2007;99:19-25.
40. Davanzo P, Yue K, Thomas MA, Belin T, Mintz J, Venkatraman TN, et al. Proton magnetic resonance spectroscopy of bipolar disorder versus intermittent explosive disorder in children and adolescents. Am J Psychiatry 2003;160:1442-1452.
41. Davanzo P, Thomas MA, Yue K, Oshiro T, Belin T, Strober M, et al. Decreased anterior cingulate myo-inositol/creatine spectroscopy resonance with lithium treatment in children with bipolar disorder. Neuropsychopharmacology 2001;24:359-369.
42. Cecil K, DelBello M, Sellars MC, Strakowski SM. Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders. J Child Adolesc Psychopharmacology 2003;13:545-555.
43. Orvaschel H. Schedule for affective disorder and schizophrenia for school-age children epidemiologic version. 5th Edition ed. Ft. Lauderdale: Nova Southeastern University, Center for Psychological Studies, 1994.
44. Young R, Biggs J, Ziegler V, Meyer D. A rating scale for mania: Reliability, validity and sensitvity. Brit J Psychiatry 1978;133:429-435.
45. Poznanski EO, Cook SC, Carroll BJ. A depression rating scale for children. Pediatrics 1979;64:442-450.
46. Wechsler D. Wechsler abbreviated scale of intelligence (WASI). 4th ed. San Antonio, Tx.: The Psychological Corporation, 1999.
47. Palomino A, Gonzalez-Pinto A, Aldama A, Gonzalez-Gomez C, Mosquera F, Gonzalez-Garcia G, et al. Decreased levels of plasma glutamate in patients with first-episode schizophrenia and bipolar disorder. Schizophr Res 2007;95:174-178.
48. Frye MA, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P, et al. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology 2007;32:2490-2499.
49. Mirza Y, Tang J, Russell A, Banerjee SP, Bhandari R, Ivey J, et al. Reduced anterior cingulate cortex glutamatergic concentrations in childhood major depression. J Am Acad Child Adolesc Psychiatry 2004;43:341-348.
50. Rajkowska G, Halaris A, Selemon LD. Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol Psychiatry 2001;49:741-752.
51. Drevets W, Ongur D, Prince J. Neuroimaging abnormalities in the subgenual prefrontal cortex: Implications for the pathophysiology of familial mood disorders. Molecular Psychiatry 1998;3:220-226.
52. Ongur D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A 1998;95:13290-13295.
53. Sanacora G, Rothman DL, Mason G, Krystal JH. Clinical studies implementing glutamate neurotransmission in mood disorders. Ann NY Acad Sci 2003;1003:292-308.
54. Eastwood SL, Harrison PJ. Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. Biol Psychiatry 2010;67:1010-1016.
55. Auer DP, Putz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study. Biol Psychiatry 2000;47:305-313.
56. Cecil KM, DelBello MP, Morey R, Strakowski SM. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord 2002;4:357-365.
57. Ongur D, Jensen JE, Prescot AP, Stork C, Lundy M, Cohen BM, et al. Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol Psychiatry 2008;64:718-726.
58. Singh M, Spielman D, Adleman N, Alegria D, Howe M, Reiss A, et al. Brain glutamatergic characteristics of pediatric offspring of parents with bipolar disorder. Psychiatry Res 2010;182:165-171.
59. Moore CM, Frazier JA, Glod CA, Breeze JL, Dieterich M, Finn CT, et al. Glutamine and glutamate levels in children ad adolescents with bipolar: A 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex. J Am Acad Child Adoles Psychiatry 2007;46:524-534.
60. Althoff RR, Rettew DC, Boomsma DI, Hudziak JJ. Latent class analysis of the child behavior checklist obsessive-compulsive scale. Compr Psychiatry 2009;50:584-592.
61. Doyle AE, Biederman J, Ferreira MA, Wong P, Smoller JW, Faraone SV. Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21. J Am Acad Child Adolesc Psychiatry;49:378-387.
62. Boomsma DI, Rebollo I, Derks EM, van Beijsterveldt TC, Althoff RR, Rettew DC, et al. Longitudinal stability of the CBCL-juvenile bipolar disorder phenotype: A study in Dutch twins. Biol Psychiatry 2006;60:912-920.
63. Zepf FD, Wockel L, Poustka F, Holtmann M. Diminished 5-HT functioning in CBCL pediatric bipolar disorder-profiled ADHD patients versus normal ADHD: Susceptibility to rapid tryptophan depletion influences reaction time performance. Hum Psychopharmacol 2008;23:291-299.
64. Holtmann M, Duketis E, Goth K, Poustka L, Boelte S. Severe affective and behavioral dysregulation in youth is associated with increased serum TSH. J Affect Disord 2010;121:184-188.
65. Ducharme S, Hudziak JJ, Botteron KN, Ganjavi H, Lepage C, Collins DL, et al. Right anterior cingulate cortical thickness and bilateral striatal volume correlate with child behavior checklist aggressive behavior scores in healthy children. Biol Psychiatry 2011;70:283-290.