Whole brain N-acetylaspartate concentration is conserved throughout normal aging

Neurobiology of Aging

Volumn 33, Issue 10, 2012, Pages 2440-2447

  Wu, William E ^a   Gass, Achim ^b   Glodzik, Lidia ^a   Babb, James S ^a   Hirsch, Jochen ^b   Sollberger, Marc ^b   Achtnichts, Lutz ^b   Amann, Michael ^b   Monsch, Andreas U ^b   Gonen, Oded ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Aging; Brain volumetry; Elderly; Healthy human brain; MRI; N acetylaspartate (NAA); Proton MR spectroscopy; Whole brain

Indexed keywords

BIOLOGICAL MARKER; N ACETYLASPARTIC ACID;

ADULT; AGE DISTRIBUTION; AGED; AGING; AMINO ACID ANALYSIS; ARTICLE; BRAIN LEVEL; BRAIN MATURATION; BRAIN NERVE CELL; BRAIN RADIOGRAPHY; BRAIN REGION; BRAIN SIZE; CONTROLLED STUDY; FEMALE; HUMAN; LIFESPAN; MALE; NEUROIMAGING; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEX DIFFERENCE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ASPARTIC ACID; ATROPHY; BIOLOGICAL MARKERS; BRAIN; BRAIN CHEMISTRY; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; ORGAN SIZE;

EID: 84864383151     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.12.008     Document Type: Article

References (53)

1. Army Individual Test Battery Manual of Directions and Scoring 1944, Army, War Department, Adjutant General's Office, Washington DC.
2. Baslow M.H. N-acetylaspartate in the vertebrate brain: metabolism and function. Neurochem. Res 2003, 28:941-953.
3. Benarroch E.E. N-acetylaspartate and N-acetylaspartylglutamate: neurobiology and clinical significance. Neurology 2008, 70:1353-1357.
4. Benedetti B., Rigotti D.J., Liu S., Filippi M., Grossman R.I., Gonen O. Reproducibility of the whole-brain N-Acetylaspartate level across institutions, MR scanners, and field strengths. AJNR Am. J. Neuroradiol 2007, 28:72-75.
5. Bitsch A., Bruhn H., Vougioukas V., Stringaris A., Lassmann H., Frahm J., Brück W. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am. J. Neuroradiol 1999, 20:1619-1627.
6. Bjartmar C., Kidd G., Mörk S., Rudick R., Trapp B.D. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann. Neurol 2000, 48:893-901.
7. Bowler J.V. Vascular cognitive impairment. J. Neurol. Neurosurg. Psychiatry 2005, 76(Suppl 5):v35-v44.
8. Chang L., Ernst T., Poland R.E., Jenden D.J. In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci 1996, 58:2049-2056.
9. Charles H.C., Lazeyras F., Krishnan K.R., Boyko O.B., Patterson L.J., Doraiswamy P.M., McDonald W.M. Proton spectroscopy of human brain: effects of age and sex. Prog. Neuropsychopharmacol. Biol. Psychiatry 1994, 18:995-1004.
10. Christiansen P., Toft P., Larsson H.B., Stubgaard M., Henriksen O. The concentration of N-acetyl aspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn. Reson. Imaging 1993, 11:799-806.
11. Das R.R., Seshadri S., Beiser A.S., Kelly-Hayes M., Au R., Himali J.J., Kase C.S., Benjamin E.J., Polak J.F., O'Donnell C.J., Yoshita M., D'Agostino R.B., DeCarli C., Wolf P.A. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke 2008, 39:2929-2935.
12. De Stefano N., Narayanan S., Francis S.J., Smith S., Mortilla M., Tartaglia M.C., Bartolozzi M.L., Guidi L., Federico A., Arnold D.L. Diffuse axonal and tissue injury in patients with multiple sclerosis with low cerebral lesion load and no disability. Arch. Neurol 2002, 59:1565-1571.
13. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. The California Verbal Learning Test 1987, Psychological Corporation, San Antonio, TX.
14. Ehrensperger M.M., Berres M., Taylor K.I., Monsch A.U. Screening properties of the German IQCODE with a two-year time frame in MCI and early Alzheimer's disease. Int. Psychogeriatr 2010, 22:91-100.
15. Falini A., Bozzali M., Magnani G., Pero G., Gambini A., Benedetti B., Mossini R., Franceschi M., Comi G., Scotti G., Filippi M. A whole brain MR spectroscopy study from patients with Alzheimer's disease and mild cognitive impairment. Neuroimage 2005, 26:1159-1163.
16. Folstein M.F., Robins L.N., Helzer J.E. The Mini-Mental State Examination. Arch. Gen. Psychiatry 1983, 40:812.
17. Fukuzako H., Hashiguchi T., Sakamoto Y., Okamura H., Doi W., Takenouchi K., Takigawa M. Metabolite changes with age measured by proton magnetic resonance spectroscopy in normal subjects. Psychiatry Clin. Neurosci 1997, 51:261-263.
18. Gómez-Isla T., Hollister R., West H., Mui S., Growdon J.H., Petersen R.C., Parisi J.E., Hyman B.T. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann. Neurol 1997, 41:17-24.
19. Gonen O., Viswanathan A.K., Catalaa I., Babb J., Udupa J., Grossman R.I. Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy. Magn. Reson. Med 1998, 40:684-689.
20. Hebert L.E., Scherr P.A., Bienias J.L., Bennett D.A., Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch. Neurol 2003, 60:1119-1122.
21. Hövener J.B., Rigotti D.J., Amann M., Liu S., Babb J.S., Bachert P., Gass A., Grossman R.I., Gonen O. Whole-brain N-acetylaspartate MR spectroscopic quantification: performance comparison of metabolite versus lipid nulling. AJNR Am. J. Neuroradiol 2008, 29:1441-1445.
22. Hoyert D.L., Kung H.C., Smith B.L. Deaths: preliminary data for 2003. Natl. Vital Stat. Rep 2005, 53:1-48.
23. Hu J., Javaid T., Arias-Mendoza F., Liu Z., McNamara R., Brown T.R. A fast, reliable, automatic shimming procedure using 1H chemical-shift-imaging spectroscopy. J. Magn. Reson. B 1995, 108:213-219.
24. Kirov I.I., Fleysher L., Fleysher R., Patil V., Liu S., Gonen O. Age dependence of regional proton metabolites T2 relaxation times in the human brain at 3 T. Magn. Reson. Med 2008, 60:790-795.
25. Lim K.O., Spielman D.M. Estimating NAA in cortical gray matter with applications for measuring changes due to aging. Magn. Reson. Med 1997, 37:372-377.
26. Marner L., Nyengaard J.R., Tang Y., Pakkenberg B. Marked loss of myelinated nerve fibers in the human brain with age. J. Comp. Neurol 2003, 462:144-152.
27. Meyer J.S., Kawamura J., Terayama Y. White matter lesions in the elderly. J. Neurol. Sci 1992, 110:1-7.
28. Meyerhoff D.J., MacKay S., Constans J.M., Norman D., Van Dyke C., Fein G., Weiner M.W. Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Ann. Neurol 1994, 36:40-47.
29. 1-weighted MRI using Bridge Burner algorithm. J. Magn. Reson. Imaging 2008, 27:1235-1241.
30. Moffett J.R., Ross B., Arun P., Madhavarao C.N., Namboodiri A.M. N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog. Neurobiol 2007, 81:89-131.
31. Morris J.C., Heyman A., Mohs R.C., Hughes J.P., van Belle G., Fillenbaum G., Mellits E.D., Clark C. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989, 39:1159-1165.
32. Mountford C.E., Stanwell P., Lin A., Ramadan S., Ross B. Neurospectroscopy: the past, present and future. Chem. Rev 2010, 110:3060-3086.
33. Parkinson's Disease: Hope Through Research NINDS. http://www.ninds.nih.gov/disorders/parkinsons_disease/detail_parkinsons_disease.htm.
34. Perret E. The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. Neuropsychologia 1974, 12:323-330.
35. Price J.L., Ko A.I., Wade M.J., Tsou S.K., McKeel D.W., Morris J.C. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch. Neurol 2001, 58:1395-1402.
36. Regard M., Strauss E., Knapp P. Children's production on verbal and non-verbal fluency tasks. Percept. Mot. Skills 1982, 55:839-844.
37. Rigotti D.J., Inglese M., Babb J.S., Rovaris M., Benedetti B., Filippi M., Grossman R.I., Gonen O. Serial whole-brain N-acetylaspartate concentration in healthy young adults. AJNR Am. J. Neuroradiol 2007, 28:1650-1651.
38. Rorden C., Brett M. Stereotaxic display of brain lesions. Behav. Neurol 2000, 12:191-200.
39. Saunders D.E., Howe F.A., van den Boogaart A., Griffiths J.R., Brown M.M. Aging of the adult human brain: in vivo quantitation of metabolite content with proton magnetic resonance spectroscopy. J. Magn. Reson. Imaging 1999, 9:711-716.
40. Scahill R.I., Frost C., Jenkins R., Whitwell J.L., Rossor M.N., Fox N.C. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch. Neurol 2003, 60:989-994.
41. Schreiber H.E., Javorsky D.J., Robinson J.E., Stern R.A. Rey-Osterrieth Complex Figure performance in adults with attention deficit hyperactivity disorder: a validation study of the Boston Qualitative Scoring System. Clin. Neuropsychol 1999, 13:509-520.
42. Schuff N., Meyerhoff D.J., Mueller S., Chao L., Sacrey D.T., Laxer K., Weiner M.W. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv. Exp. Med. Biol 2006, 576:241-262. Discussion, 361-243.
43. Smith S.M. Fast robust automated brain extraction. Hum. Brain Mapp 2002, 17:143-155.
44. Soher B.J., van Zijl P.C., Duyn J.H., Barker P.B. Quantitative proton MR spectroscopic imaging of the human brain. Magn. Reson. Med 1996, 35:356-363.
45. Tang Y., Nyengaard J.R., Pakkenberg B., Gundersen H.J. Age-induced white matter changes in the human brain: a stereological investigation. Neurobiol. Aging 1997, 18:609-615.
46. Thalmann B., Spiegel R., Stähelin H.B., Brubacher D., Ermini-Fünfschilling D., Bläsi S., Monsch A.U. Dementia screening in general practice: optimised scoring for the Clock Drawing Test. Brain Aging 2002, 2:36-43.
47. Thurstone L.L. Primary Mental Abilities 1938, University of Chicago Press, Chicago.
48. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mörk S., Bö L. Axonal transection in the lesions of multiple sclerosis. N Engl J. Med 1998, 338:278-285.
49. Vernooij M.W., van der Lugt A., Ikram M.A., Wielopolski P.A., Niessen W.J., Hofman A., Krestin G.P., Breteler M.M. Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008, 70:1208-1214.
50. Wahlund L.O., Barkhof F., Fazekas F., Bronge L., Augustin M., Sjögren M., Wallin A., Ader H., Leys D., Pantoni L., Pasquier F., Erkinjuntti T., Scheltens P. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 2001, 32:1318-1322. European Task Force on Age-Related White Matter Changes.
51. Wechsler D.A. Wechsler Memory Scale-Revised Manual 1987, Psychological Corporation, New York.
52. WHO. http://www.who.int/classifications/icd/icdonlineversions/en/index.html.
53. Zimmermann P., Fimm B. Test battery for attention speed assessment Herzogenrath. http://www.psytest.de/.