Aging of the adult human brain: In vivo quantitation of metabolite content with proton magnetic resonance spectroscopy

Journal of Magnetic Resonance Imaging

Volumn 9, Issue 5, 1999, Pages 711-716

  Saunders, Dawn E ^a   Howe, Franklyn A ^a   Van Den Boogaart, Aad ^a   Griffiths, John R ^a   Brown, Martin M ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Aging; Magnetic resonance spectroscopy; Quantitation

Indexed keywords

N ACETYLASPARTIC ACID;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; BRAIN TUMOR; CEREBROSPINAL FLUID; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; GRAY MATTER; HUMAN; OCCIPITAL LOBE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEX DIFFERENCE; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; AGING; ASPARTIC ACID; BRAIN; BRAIN CHEMISTRY; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; REFERENCE VALUES;

EID: 0032953642     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2586(199905)9:5<711::AID-JMRI14>3.0.CO;2-3     Document Type: Article

References (36)

1. Myerson J, Hale S, Wagstaff D, Poon LW, Smith GA. The informationloss model: a mathematical theory of age-related cognitive slowing. Psychol Rev 1990;97:475-587.
2. Mayr U, Kliegl R. Sequential and coordinate complexity: age-based processing limitations in figural transformations. Exp Psychol Learn Mem Cogn 1997;19:1297-1320.
3. Rao SM, Mittenberg W, Bernardin L, Haughton V, Leo GJ. Neurological test findings in subjects with leukoariosis. Arch Neurol 1997;46: 40-44.
4. Moats RA, Ernst T, Shonk TK, Ross BD. Abnormal cerebral metabolite concentrations in patients with probable Alzheimer's disease. Magn Reson Med 1994;32:110-115.
5. Matsuda H, Maeda T, Yamada M, Luo X, Hisada K. Age matched normal values and judgment image in regional cerebral blood flow measurements by 133-Xe inhalation. rCBF Bull 1982;5:97-100.
6. Pantona P, Baron J, Lebrun-Grandie P, Duquesnoy N, Bousser M, Comar D. Regional cerebral blood flow and oxygen consumption in human aging. Stroke 1984;15:635-641.
7. Leeanders KL, Perani D, Lammertsma AA, et al. Cerebral blood flow, blood volume and oxygen utilization - normal values and effects of age. Brain 1990;113:27-47.
8. Martin AJ, Friston KJ, Colebatch JG, Frackowiak, RS. Decreases in regional cerebral blood flow with normal aging. J Cereb Blood Flow Metab 1991;11:684-689.
9. 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989;13:23-31.
10. Bruhn H, Stoppe G, Merboldt KD, Michaelis T, Hanicke W, Frahm J. Cerebral metabolite alterations in normal aging and Alzheimer's dementia. In: Proceedings of the Society of Magnetic Resonance in Medicine, 1992. 1:752 (Abstract)
11. Charles HC, Lazeyras F, Ranga Rama Krishman K, et al. Proton spectroscopy of human brain: effects of age and sex. Prog Neuropsy-chopharmacol Biol Psychiatry 1994;18:995-1004.
12. Soher BJ, van Zijl PCM, Barker PB. Quantitative proton MR spectroscopic imaging of human brain. Magn Reson Med 1996;35: 356-363.
13. Chang L, Ernst T, Poland RE, Jenden DJ. In vivo proton magnetic resonance spectroscopy of the normal aging brain. Life Sci 1996;22: 2049-2056.
14. Manton DJ, Lowry M, Blackband S, Horsman A. Determination of proton metabolite concentrations and relaxation parameters in normal human brain and intracranial tumours. NMR Biomed 1995;8:104-112.
15. Saunders DE, Howe FA, McLean MA, van den Boogart A, Griffiths JR. Brown MM. Quantitative proton spectroscopy in acute stroke. Proc Soc Magn Reson 1994;1:188 (Abstract)
16. Webb PG, Sailasuta N, Kohler SJ, Raidy T, Moats RA, Hurd R. Automated single-voxel proton MRS: technical development and multisite verification. Magn Reson Med 1994;31:365-373.
17. Frahm J, Merboldt KD, Hanicke W. Localized proton spectroscopy using stimulated echoes. J Magn Reson 1987;72:502-508.
18. Saunders DE, Howe FA, van den Boogart A, McClean MA, Griffiths JR, Brown MM. Continuing ischaemic damage after acute middle cerebral infacrtion in humans demonstrated by short-echo proton spectroscopy. Stroke 1995;26:1007-1013.
19. de Beer R, van Ormondt D, Pijnappel WWF, van der Veen JWC. Quantitative analysis of magnetic resonance signals in the time domain. Isr J Chem 1988;28:249-261.
20. 31P NMR signals using the variable projection method and prior knowledge. Magn Reson Med 1988;6:92-98.
21. Klose U. In vivo proton spectroscopy in presence of eddy currents. Magn Reson Med 1990;14:26-30.
22. 1H magnetic resonance spectra. In: McWhirter JG, editor. Mathematics in signal processing III. Oxford: Clarendon Press; 1994. p 175-195.
23. Frahm J, Bruhn H, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Localized high-resolution proton NMR spectroscopy using stimulated etChoes: initial applications to human brain in vivo. Magn Reson Med 1989;9:79-93.
24. Michaelis T, Merboldt KD, Hanicke W, Gyngell ML, Bruhn H, Frahm J. On the identification of cerebral metabolites in localized 1H-NMR spectra of human brain in vivo. NMR Biomed 1991;4:90-98.
25. Michaelis T, Merboldt KD, Bruhn H, Hanicke W, Frahm J. Absolute concentrations of metabolites in the human brain in vivo: quantification of localized proton MR spectra. Radiology 1993;187:219-227.
26. Hanley T "Neuronal fall-out" in the aging brain: critical reveiw of the quantitative data. Age Aging 1974;3:133-151.
27. Terry RD, DeTeresa R, Hansen LA. Neocortical cell counts in normal human aging. Ann Neurol 1987;21:530-539.
28. Videen JS, Michaelis T, Pinto P, Ross BD. Human cerebral osmolytes during chronic hyponatraemia. A proton magnetic resonance spectroscopy study. J Clin Invest 1995;2:788-93.
29. Haussinger D, Laubenberger J, vom Dahl S, et al. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 1994;107:1475-1480.
30. Barker PB, Breiter S, Soher BJ, et al. Quantitative proton spectroscopy of canine brain: in vivo and in vitro correlations. Magn Reson Med 1994;32:157-163.
31. Christiansen P, Toft PB, Larsson HBW, Stubgaard M, Henriksen O. The concentration of JV-acetyl aspartate, creatine + phosphocreatine, and tCholine in different parts of the brain in adulthood and the senium. Magn Reson Imaging 1993;11:799-806.
32. Kreis R, Ernst T, Ross BD. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations. J Magn Reson 1993;102:9-19.
33. Barker PB, Soher BJ, Blackband SJ, Chatham JC, Mathews VP, Bryan RN. Quantitation of proton NMR spectra of the human brain using water as an internal concentration reference. NMR Biomed 1993;6:89-94.
34. May GL, Wright LC, Holmes KT, et al. Assignment of methylene proton resonances in NMR spectra of embryonic and transformed cells to plasma membrane triglyceride. J Biol Chem 1986;261:3048-3053.
35. Wilkinson ID, Paley MN, Miszkiel KA, et al. Cerebral volumes and spectroscopic proton metabolites on MR: is sex important? Magn Reson Imaging 1997, 15:243-248.
36. Salthouse TA. Attentional blocks are not responsible for age-related slowing. J Gerontol Psychol Sci 1993;48:263-270.