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Volumn 41, Issue 7, 2012, Pages 547-558

Migration induced by epidermal and hepatocyte growth factors in oral squamous carcinoma cells in vitro: Role of MEK/ERK, p38 and PI-3 kinase/Akt

Author keywords

Epidermal growth factor; Hepatocyte growth factor; Migration; Oral cancer

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCATTER FACTOR;

EID: 84864382214     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2012.01139.x     Document Type: Article
Times cited : (29)

References (57)
  • 2
  • 3
    • 17744387334 scopus 로고    scopus 로고
    • Tumor cell invasion and survival in head and neck cancer
    • Kramer R, Shen X, Zhou H. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev 2005; 24: 35-45.
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 35-45
    • Kramer, R.1    Shen, X.2    Zhou, H.3
  • 4
    • 33746344387 scopus 로고    scopus 로고
    • The extracellular matrix in oral squamous cell carcinoma: friend or foe?
    • Ziober AF, Falls EM, Ziober BL. The extracellular matrix in oral squamous cell carcinoma: friend or foe? Head Neck 2006; 28: 740-9.
    • (2006) Head Neck , vol.28 , pp. 740-749
    • Ziober, A.F.1    Falls, E.M.2    Ziober, B.L.3
  • 5
    • 38449122460 scopus 로고    scopus 로고
    • HGF and c-MET as potential orchestrators of invasive growth in head and neck squamous cell carcinoma
    • De Herdt MJ, Baatenburg de Jong RJ. HGF and c-MET as potential orchestrators of invasive growth in head and neck squamous cell carcinoma. Front Biosci 2008; 13: 2516-26.
    • (2008) Front Biosci , vol.13 , pp. 2516-2526
    • De Herdt, M.J.1    Baatenburg de Jong, R.J.2
  • 6
    • 33748188459 scopus 로고    scopus 로고
    • Epidermal growth factor receptor biology in head and neck cancer
    • Kalyankrishna S, Grandis JR. Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol 2006; 24: 2666-72.
    • (2006) J Clin Oncol , vol.24 , pp. 2666-2672
    • Kalyankrishna, S.1    Grandis, J.R.2
  • 7
    • 70350228491 scopus 로고    scopus 로고
    • Collective cell migration
    • Rørth P. Collective cell migration. Annu Rev Cell Dev Biol 2009; 25: 407-29.
    • (2009) Annu Rev Cell Dev Biol , vol.25 , pp. 407-429
    • Rørth, P.1
  • 8
    • 66449127943 scopus 로고    scopus 로고
    • Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling
    • Neiva KG, Zhang Z, Miyazawa M, Warner KA, Karl E, Nor JE. Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling. Neoplasia 2009; 11: 583-93.
    • (2009) Neoplasia , vol.11 , pp. 583-593
    • Neiva, K.G.1    Zhang, Z.2    Miyazawa, M.3    Warner, K.A.4    Karl, E.5    Nor, J.E.6
  • 9
    • 75749146306 scopus 로고    scopus 로고
    • Plasticity of cell migration: a multiscale tuning model
    • Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol 2010; 188: 11-9.
    • (2010) J Cell Biol , vol.188 , pp. 11-19
    • Friedl, P.1    Wolf, K.2
  • 11
    • 34547226194 scopus 로고    scopus 로고
    • Regulation of MAPKs by growth factors and receptor tyrosine kinases
    • Katz M, Amit I, Yarden Y. Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim Biophys Acta 2007; 1773: 1161-76.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1161-1176
    • Katz, M.1    Amit, I.2    Yarden, Y.3
  • 12
    • 67349087907 scopus 로고    scopus 로고
    • Coordinated integrin and growth factor regulation of primary keratinocyte migration mediated through extracellular signal regulated kinase and phosphoinositide 3-kinase
    • Watson A, Morris VL, Chan BM. Coordinated integrin and growth factor regulation of primary keratinocyte migration mediated through extracellular signal regulated kinase and phosphoinositide 3-kinase. Arch Dermatol Res 2009; 301: 307-17.
    • (2009) Arch Dermatol Res , vol.301 , pp. 307-317
    • Watson, A.1    Morris, V.L.2    Chan, B.M.3
  • 13
    • 77951568703 scopus 로고    scopus 로고
    • Phosphoinositide signalling in cancer: beyond PI3K and PTEN
    • Bunney TD, Katan M. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 2010; 10: 342-52.
    • (2010) Nat Rev Cancer , vol.10 , pp. 342-352
    • Bunney, T.D.1    Katan, M.2
  • 14
    • 66149135285 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
    • Seiwert TY, Jagadeeswaran R, Faoro L, et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res 2009; 69: 3021-31.
    • (2009) Cancer Res , vol.69 , pp. 3021-3031
    • Seiwert, T.Y.1    Jagadeeswaran, R.2    Faoro, L.3
  • 15
    • 73249143536 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
    • Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010; 11: 21-8.
    • (2010) Lancet Oncol , vol.11 , pp. 21-28
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 16
    • 77955906924 scopus 로고    scopus 로고
    • Emerging drugs to treat squamous cell carcinomas of the head and neck
    • Fung C, Grandis JR. Emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin Emerg Drugs 2010; 15: 355-73.
    • (2010) Expert Opin Emerg Drugs , vol.15 , pp. 355-373
    • Fung, C.1    Grandis, J.R.2
  • 17
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 2010; 141: 1117-34.
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 20
    • 34848855124 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase in invasion and metastasis
    • Benvenuti S, Comoglio PM. The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 2007; 213: 316-25.
    • (2007) J Cell Physiol , vol.213 , pp. 316-325
    • Benvenuti, S.1    Comoglio, P.M.2
  • 21
    • 0242654881 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissues
    • Ohnishi T, Daikuhara Y. Hepatocyte growth factor/scatter factor in development, inflammation and carcinogenesis: its expression and role in oral tissues. Arch Oral Biol 2003; 48: 797-804.
    • (2003) Arch Oral Biol , vol.48 , pp. 797-804
    • Ohnishi, T.1    Daikuhara, Y.2
  • 22
    • 77955125000 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model
    • Brusevold IJ, Soland TM, Khuu C, Christoffersen T, Bryne M. Nuclear and cytoplasmic expression of Met in oral squamous cell carcinoma and in an organotypic oral cancer model. Eur J Oral Sci 2010; 118: 342-9.
    • (2010) Eur J Oral Sci , vol.118 , pp. 342-349
    • Brusevold, I.J.1    Soland, T.M.2    Khuu, C.3    Christoffersen, T.4    Bryne, M.5
  • 23
    • 33846641194 scopus 로고    scopus 로고
    • High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis
    • Laimer K, Spizzo G, Gastl G, et al. High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncol 2007; 43: 193-8.
    • (2007) Oral Oncol , vol.43 , pp. 193-198
    • Laimer, K.1    Spizzo, G.2    Gastl, G.3
  • 24
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: towards the systems level
    • Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006; 7: 505-16.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 25
    • 42149177825 scopus 로고    scopus 로고
    • The regulation of cell motility and chemotaxis by phospholipid signaling
    • Kolsch V, Charest PG, Firtel RA. The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci 2008; 121: 551-9.
    • (2008) J Cell Sci , vol.121 , pp. 551-559
    • Kolsch, V.1    Charest, P.G.2    Firtel, R.A.3
  • 26
    • 29144488505 scopus 로고    scopus 로고
    • Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
    • Irie HY, Pearline RV, Grueneberg D, et al. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 2005; 171: 1023-34.
    • (2005) J Cell Biol , vol.171 , pp. 1023-1034
    • Irie, H.Y.1    Pearline, R.V.2    Grueneberg, D.3
  • 27
    • 42949102509 scopus 로고    scopus 로고
    • The p38 MAPK stress pathway as a tumor suppressor or more?
    • Loesch M, Chen G. The p38 MAPK stress pathway as a tumor suppressor or more? Front Biosci 2008; 13: 3581-93.
    • (2008) Front Biosci , vol.13 , pp. 3581-3593
    • Loesch, M.1    Chen, G.2
  • 28
    • 40649123593 scopus 로고    scopus 로고
    • Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells
    • Ye M, Hu D, Tu L, et al. Involvement of PI3K/Akt signaling pathway in hepatocyte growth factor-induced migration of uveal melanoma cells. Invest Ophthalmol Vis Sci 2008; 49: 497-504.
    • (2008) Invest Ophthalmol Vis Sci , vol.49 , pp. 497-504
    • Ye, M.1    Hu, D.2    Tu, L.3
  • 29
    • 84860389234 scopus 로고    scopus 로고
    • Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin
    • Zuo JH, Zhu W, Li MY, et al. Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin. J Cell Biochem 2011; 112: 2508-17.
    • (2011) J Cell Biochem , vol.112 , pp. 2508-2517
    • Zuo, J.H.1    Zhu, W.2    Li, M.Y.3
  • 30
    • 77956941983 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
    • Wheeler SE, Suzuki S, Thomas SM, et al. Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation. Oncogene 2010; 29: 5135-45.
    • (2010) Oncogene , vol.29 , pp. 5135-5145
    • Wheeler, S.E.1    Suzuki, S.2    Thomas, S.M.3
  • 31
    • 80655149151 scopus 로고    scopus 로고
    • Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells
    • Holz C, Niehr F, Boyko M, et al. Epithelial-mesenchymal-transition induced by EGFR activation interferes with cell migration and response to irradiation and cetuximab in head and neck cancer cells. Radiother Oncol 2011; 101: 158-64.
    • (2011) Radiother Oncol , vol.101 , pp. 158-164
    • Holz, C.1    Niehr, F.2    Boyko, M.3
  • 32
    • 33846260178 scopus 로고    scopus 로고
    • Cross-talk between G protein coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma
    • Thomas SM, Bhola NE, Zhang Q, et al. Cross-talk between G protein coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. Cancer Res 2006; 66: 11831-9.
    • (2006) Cancer Res , vol.66 , pp. 11831-11839
    • Thomas, S.M.1    Bhola, N.E.2    Zhang, Q.3
  • 33
    • 78649889063 scopus 로고    scopus 로고
    • EGF receptor activation by GPCRs: an universal pathway reveals different versions
    • Liebmann C. EGF receptor activation by GPCRs: an universal pathway reveals different versions. Mol Cell Endocrinol 2011; 331: 222-31.
    • (2011) Mol Cell Endocrinol , vol.331 , pp. 222-231
    • Liebmann, C.1
  • 34
    • 0028053831 scopus 로고
    • Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells
    • Matsumoto K, Matsumoto K, Nakamura T, Kramer RH. Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J Biol Chem 1994; 269: 31807-13.
    • (1994) J Biol Chem , vol.269 , pp. 31807-31813
    • Matsumoto, K.1    Matsumoto, K.2    Nakamura, T.3    Kramer, R.H.4
  • 35
    • 0036781822 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor stimulates mitogenesis and migration of a head and neck squamous cell carcinoma cell line
    • Fleigel J, Sedwick J, Kornberg LJ. Hepatocyte growth factor/scatter factor stimulates mitogenesis and migration of a head and neck squamous cell carcinoma cell line. Otolaryngol Head Neck Surg 2002; 127: 271-8.
    • (2002) Otolaryngol Head Neck Surg , vol.127 , pp. 271-278
    • Fleigel, J.1    Sedwick, J.2    Kornberg, L.J.3
  • 36
    • 0037067672 scopus 로고    scopus 로고
    • Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B
    • Zeng Q, Chen S, You Z, et al. Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B. J Biol Chem 2002; 277: 25203-8.
    • (2002) J Biol Chem , vol.277 , pp. 25203-25208
    • Zeng, Q.1    Chen, S.2    You, Z.3
  • 37
    • 34347218991 scopus 로고    scopus 로고
    • In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
    • Liang CC, Park AY, Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007; 2: 329-33.
    • (2007) Nat Protoc , vol.2 , pp. 329-333
    • Liang, C.C.1    Park, A.Y.2    Guan, J.L.3
  • 38
    • 62649161864 scopus 로고    scopus 로고
    • PGE2 production in oral cancer cell lines is COX-2-dependent
    • Husvik C, Khuu C, Bryne M, Halstensen TS. PGE2 production in oral cancer cell lines is COX-2-dependent. J Dent Res 2009; 88: 164-9.
    • (2009) J Dent Res , vol.88 , pp. 164-169
    • Husvik, C.1    Khuu, C.2    Bryne, M.3    Halstensen, T.S.4
  • 39
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: a MET-driven genetic programme for cancer and stem cells
    • Boccaccio C, Comoglio PM. Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 2006; 6: 637-45.
    • (2006) Nat Rev Cancer , vol.6 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 40
    • 63049100044 scopus 로고    scopus 로고
    • Functional selectivity of EGF family peptide growth factors: implications for cancer
    • Wilson KJ, Gilmore JL, Foley J, Lemmon MA, Riese DJ II. Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacol Ther 2009; 122: 1-8.
    • (2009) Pharmacol Ther , vol.122 , pp. 1-8
    • Wilson, K.J.1    Gilmore, J.L.2    Foley, J.3    Lemmon, M.A.4    Riese II, D.J.5
  • 41
    • 0028084891 scopus 로고
    • Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis
    • Chen P, Gupta K, Wells A. Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J Cell Biol 1994; 124: 547-55.
    • (1994) J Cell Biol , vol.124 , pp. 547-555
    • Chen, P.1    Gupta, K.2    Wells, A.3
  • 42
    • 0037429725 scopus 로고    scopus 로고
    • The ErbB receptors and their role in cancer progression
    • Holbro T, Civenni G, Hynes NE. The ErbB receptors and their role in cancer progression. Exp Cell Res 2003; 284: 99-110.
    • (2003) Exp Cell Res , vol.284 , pp. 99-110
    • Holbro, T.1    Civenni, G.2    Hynes, N.E.3
  • 43
    • 79955083789 scopus 로고    scopus 로고
    • Cetuximab in the treatment of squamous cell carcinoma of the head and neck
    • Specenier P, Vermorken JB. Cetuximab in the treatment of squamous cell carcinoma of the head and neck. Expert Rev Anticancer Ther 2011; 11: 511-24.
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 511-524
    • Specenier, P.1    Vermorken, J.B.2
  • 44
    • 0141592701 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma
    • Thomas SM, Coppelli FM, Wells A, et al. Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma. Cancer Res 2003; 63: 5629-35.
    • (2003) Cancer Res , vol.63 , pp. 5629-5635
    • Thomas, S.M.1    Coppelli, F.M.2    Wells, A.3
  • 45
    • 24344452432 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas
    • Ren Y, Cao B, Law S, et al. Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clin Cancer Res 2005; 11: 6190-7.
    • (2005) Clin Cancer Res , vol.11 , pp. 6190-6197
    • Ren, Y.1    Cao, B.2    Law, S.3
  • 46
    • 66649131963 scopus 로고    scopus 로고
    • HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    • Knowles LM, Stabile LP, Egloff AM, et al. HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer. Clin Cancer Res 2009; 15: 3740-50.
    • (2009) Clin Cancer Res , vol.15 , pp. 3740-3750
    • Knowles, L.M.1    Stabile, L.P.2    Egloff, A.M.3
  • 47
    • 35948964766 scopus 로고    scopus 로고
    • Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1
    • Matsushita A, Gotze T, Korc M. Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Cancer Res 2007; 67: 10309-16.
    • (2007) Cancer Res , vol.67 , pp. 10309-10316
    • Matsushita, A.1    Gotze, T.2    Korc, M.3
  • 48
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • Kim EK, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 2010; 1802: 396-405.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 396-405
    • Kim, E.K.1    Choi, E.J.2
  • 49
    • 33744544424 scopus 로고    scopus 로고
    • p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
    • Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell 2006; 125: 957-69.
    • (2006) Cell , vol.125 , pp. 957-969
    • Zohn, I.E.1    Li, Y.2    Skolnik, E.Y.3    Anderson, K.V.4    Han, J.5    Niswander, L.6
  • 50
    • 33646197380 scopus 로고    scopus 로고
    • Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for Met-triggered cortical neuron migration
    • Segarra J, Balenci L, Drenth T, Maina F, Lamballe F. Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for Met-triggered cortical neuron migration. J Biol Chem 2006; 281: 4771-8.
    • (2006) J Biol Chem , vol.281 , pp. 4771-4778
    • Segarra, J.1    Balenci, L.2    Drenth, T.3    Maina, F.4    Lamballe, F.5
  • 51
    • 76749171745 scopus 로고    scopus 로고
    • Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion
    • Menakongka A, Suthiphongchai T. Involvement of PI3K and ERK1/2 pathways in hepatocyte growth factor-induced cholangiocarcinoma cell invasion. World J Gastroenterol 2010; 16: 713-22.
    • (2010) World J Gastroenterol , vol.16 , pp. 713-722
    • Menakongka, A.1    Suthiphongchai, T.2
  • 52
    • 77955611532 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells
    • Dilly M, Hambruch N, Haeger JD, Pfarrer C. Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells. Mol Reprod Dev 2010; 77: 622-9.
    • (2010) Mol Reprod Dev , vol.77 , pp. 622-629
    • Dilly, M.1    Hambruch, N.2    Haeger, J.D.3    Pfarrer, C.4
  • 53
    • 77953794483 scopus 로고    scopus 로고
    • CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity
    • Sciaccaluga M, Fioretti B, Catacuzzeno L, et al. CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity. Am J Physiol Cell Physiol 2010; 299: C175-84.
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Sciaccaluga, M.1    Fioretti, B.2    Catacuzzeno, L.3
  • 54
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316: 1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 55
    • 77952800807 scopus 로고    scopus 로고
    • Receptor tyrosine kinase coactivation networks in cancer
    • Xu AM, Huang PH. Receptor tyrosine kinase coactivation networks in cancer. Cancer Res 2010; 70: 3857-60.
    • (2010) Cancer Res , vol.70 , pp. 3857-3860
    • Xu, A.M.1    Huang, P.H.2
  • 56
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with EGFR inhibitor erlotinib in an HGF-dependent fashion to suppress carcinoma growth
    • Zhang YW, Staal B, Essenburg C, et al. MET kinase inhibitor SGX523 synergizes with EGFR inhibitor erlotinib in an HGF-dependent fashion to suppress carcinoma growth. Cancer Res 2010; 70: 6880-90.
    • (2010) Cancer Res , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1    Staal, B.2    Essenburg, C.3
  • 57
    • 79960300164 scopus 로고    scopus 로고
    • Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells
    • Xu H, Stabile LP, Gubish CT, Gooding WE, Grandis JR, Siegfried JM. Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. Clin Cancer Res 2011; 17: 4425-38.
    • (2011) Clin Cancer Res , vol.17 , pp. 4425-4438
    • Xu, H.1    Stabile, L.P.2    Gubish, C.T.3    Gooding, W.E.4    Grandis, J.R.5    Siegfried, J.M.6


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