Granulin mutation drives brain damage and reorganization from preclinical to symptomatic FTLD

Neurobiology of Aging

Volumn 33, Issue 10, 2012, Pages 2506-2520

  Borroni, Barbara ^a   Alberici, Antonella ^a   Cercignani, Mara ^b   Premi, Enrico ^a   Serra, Laura ^b   Cerini, Carlo ^a   Cosseddu, Maura ^a   Pettenati, Carla ^c   Turla, Marinella ^d   Archetti, Silvana ^e   Gasparotti, Roberto ^a   Caltagirone, Carlo ^b,f   Padovani, Alessandro ^a   Bozzali, Marco ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c Alzheimer Centre   (Italy)

^d Vallecamonica Hospital   (Italy)

^e Department of Paediatrics   (Italy)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Frontotemporal lobar degeneration; Granulin; Preclinical; Progranulin; Resting state fMRI; Voxel based morphometry

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN ATROPHY; BRAIN DAMAGE; BRAIN MAPPING; BRAIN REGION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; FEMALE; FRONTOTEMPORAL DEMENTIA; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE MUTATION; GENETIC ASSOCIATION; GRANULIN GENE; GRAY MATTER; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATOR GENE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; VOXEL BASED MORPHOMETRY;

AGE OF ONSET; AGED; BRAIN DAMAGE, CHRONIC; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MUTATION; NERVE NET; NEURONAL PLASTICITY;

EID: 84864380641     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.10.031     Document Type: Article

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