Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 1003-1011

  Vásquez, David R ^a,c   Verrax, Julien ^b   Valderrama, Jaime A ^a,c   Calderon, Pedro Buc ^b,c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c UNIVERSIDAD ARTURO PRAT   (Chile)

Author keywords

Cancer; Cell death; Oxidative stress; Quinones; Redox cycling; ROS formation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE TRIPHOSPHATE; AMINOPYRIMIDOISOQUINOLINEQUINONE DERIVATIVE; ASCORBIC ACID; CASPASE 3; INITIATION FACTOR 2ALPHA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DEATH; CELL ISOLATION; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LEUKEMIA; MITOSIS INHIBITION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION;

ADULT; ASCORBIC ACID; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYTOSTATIC AGENTS; FEMALE; HUMANS; L-LACTATE DEHYDROGENASE; LEUKOCYTES; MALE; MIDDLE AGED; NECROSIS; NEOPLASMS; OXIDATION-REDUCTION; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; QUINOLONES; REACTIVE OXYGEN SPECIES;

EID: 84864372874     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9661-1     Document Type: Article

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